chondrosarcoma-associated protein 2 (taxol-resistant-associated protein 3, TRAG-3, CSAG2, TRAG3)

Function: - drug-resistance related protein - expression is associated with the chemotherapy resistant & neoplastic phenotype - may also be linked to the malignant phenotype Alternative splicing: named isoforms=2 Expression: weakly expressed in kidney Pathology: - expressed in various tumor cell lines including carcinomas, myeloid & lymphoid malignancies, melanomas & prostate cancer - overexpressed in taxol-resistant breast cancer line MDA 435(TR) & the doxorubicin-resistant multiple myelanoma lines 8226/Dox(40) & 8226/MDR(10)V

Properties

SIZE: MW = 14 kD entity length = 127 aa

References

UniProt :accession Q9Y5P2