Search
cryofibrinogenemia
Etiology:
- paraneoplastic syndrome
- lung carcinoma
- gastric carcinoma
- colon carcinoma
- metastatic prostate carcinoma
- multiple myeloma
- inflammatory diseases
- rheumatic fever
- ulcerative colitis
- thromboembolism
- idiopathic
Epidemiology:
- rare
Pathology:
- precipitates of fibrinogen, fibrin, fibronectin &/or fibrin degradation products at cooler temperatures
- fibrin thrombi within superficial dermal vessels
Clinical manifestations:
- purpura
- livedo reticularis
- painful ulcerations, usually on the legs & unresponsive to treatment
Management:
- symptomatic
- treat underlying etiology
- treatment based on limited experience has included:
- heparin, warfarin, dicumarol, streptokinase, streptodornase, plasmapheresis, dapsone, azathioprine, prednisone, stanozolol
- stanozole 2 mg PO BID may be effective for cutaneous ulcers [2]
Related
cryoglobulinemia (cryoglobulinemic vasculitis)
General
hypercoagulability
References
- Focus Diagnostics: Cryofibrinogen
http://www.focusdx.com/focus/1-reference_laboratory/print_prod.asp?unitCode=20318
- Medscape Oncology: Diagnostic Dilemmas: Diagnosis and Dicussion
http://www.medscape.com/viewarticle/407552_4