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crush syndrome

Shock & renal failure following soft tissue injury. Etiology: - rhabdomyolysis Clinical manifestations: 1) signs of injury 2) shock 3) oliguria 4) pain 5) somnolence 6) thirst 7) nausea Laboratory: 1) increased serum markers of muscle injury a) serum creatine kinase* b) serum myoglobin 2) increased serum urea nitrogen 3) serum K+: hyperkalemia 5) serum Na+: hyponatremia 6) urine myoglobin: myoglobinuria* * serum creatinine kinase (> 5x upper limit of normal) for diagnosis [2] * urine myoglobin for management (see rhabdomyolysis) [3]

General

syndrome

References

  1. DeGowin & DeGowin's Diagnostic Examination, 6th edition, RL DeGowin (ed), McGraw Hill, NY 1994, pg 876
  2. NEJM Knowledge+ Nephrology/Urology
  3. Medical Knowledge Self Assessment Program (MKSAP) 15, 16, 17, 18. American College of Physicians, Philadelphia 2009, 2012, 2015, 2018