dihydropyrimidinase-related protein 2; DRP-2; collapsin response mediator protein 2; CRMP-2; N2A3; Unc-33-like phosphoprotein 2; ULIP-2 (DPYSL2, CRMP2, ULIP2)

Function: - necessary for signaling by class 3 semaphorins & subsequent remodeling of the cytoskeleton - role in axon guidance, neuronal growth cone collapse & cell migration - homotetramer, & heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5 (putative) - interacts through its C-terminus with the C-terminus of CYFIP1/SRA1 - interacts with HTR4 Structure: - belongs to the DHOase family, hydantoinase/dihydropyrimidinase subfamily - lacks most of the conserved residues essential for binding the metal cofactor & hence for dihydropyrimidinase activity Compartment: cytoplasm (putative) Expression: ubiquitous Pathology: - 3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 & Thr-509

Properties

SIZE: entity length = 572 aa MW = 62 kD COMPARTMENT: cytoplasm MOTIF: Tyr phosphorylation site {Y32} Tyr phosphorylation site {Y431} Thr phosphorylation site {T462} Ser phosphorylation site {S465} Tyr phosphorylation site {Y499} Thr phosphorylation site {T509} Thr phosphorylation site {T512} Thr phosphorylation site {T514} Ser phosphorylation site {S517} Ser phosphorylation site {S518} Thr phosphorylation site {T521} Ser phosphorylation site {S522} Ser phosphorylation site {S542}

Database Correlations

OMIM 602463 UniProt Q16555 Pfam PF01979 Entrez Gene 1808 Kegg hsa:1808

References

UniProt :accession Q16555