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cysteine-rich PAK1 inhibitor (CRIPak, CRIPAK)
Function:
- negative regulator of PAK1
- interacts with PAK1
Compartment:
- cytoplasm, membrane, nucleus
- translocated to the nuclear compartment upon hormonal treatment by estrogen
Expression:
- widely expressed
- highest espression observed in trachea, prostate & adrenal glands
- up-regulated by estrogen
Pathology:
- expressed in many cancer cell lines including breast cancer cells
- loss of CRIPAK in breast tumors might contribute to hormonal independence
Properties
GENERAL: uncharacterized protein
SIZE: entity length = 446 aa
MW = 48 kD
COMPARTMENT: cytoplasm
cell nucleus
FORM: cysteine-rich PAK1 inhibitor
MOTIF: 1 {34-50}
2 {106-122}
3 {137-153}
4 {168-184}
5 {199-215}
6 {230-246}
7 {250-266}
8 {270-286}
9 {321-337}
PAK1 interaction {367-446}
MOTIF: 10 {374-390}
Database Correlations
Kegg hsa:2854
References
UniProt :accession Q8N1N5 (deprecated)