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corticotropin-releasing factor; corticoliberin; CRF; corticotropin-releasing hormone (CRH)
Function:
- regulates release of corticotropin from pituitary gland
- interacts (via C-terminus) with CRFR1 (via N-terminal extracellular domain)
Structure:
- belongs to the sauvagine/corticotropin-releasing factor/ urotensin I family
Compartment: secreted
Expression:
- secreted by hypothalamus
Related
adrenocorticotropic hormone; corticotropin; adrenocorticotropin (ACTH)
corticotropin-releasing factor/hormone [CRF/CRH] receptor
corticotropin-releasing hormone (CRH) stimulation test
General
pituitary hormone-releasing hormone; hypothalamic hormone
Properties
SIZE: entity length = 196 aa
MW = 21 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-24}
Database Correlations
OMIM 122560
UniProt P06850
Pfam PF00473
Entrez Gene 1392
Kegg hsa:1392
References
- UniProt :accession P06850
- Wikipedia; Note: corticotropin-releasing hormone entry
http://en.wikipedia.org/wiki/corticotropin-releasing_hormone