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corticotropin-releasing factor receptor 2; CRF-R 2; CRF2; corticotropin-releasing hormone receptor 2; CRH-R 2 (CRHR2 CRF2R CRH2R)
Function:
- receptor for corticotropin releasing factor
- high-affinity CRF binding
- also binds to urocortin 1, 2 & 3
- activity is mediated by G proteins which activate adenylyl cyclase
Structure: belongs to the G-protein coupled receptor 2 family
Compartment: cell membrane
Alternative splicing: named isoforms=3; alpha, beta, gamma
General
corticotropin-releasing factor/hormone [CRF/CRH] receptor
Properties
SIZE: entity length = 411 aa
MW = 48 kD
COMPARTMENT: plasma membrane
CELL: neuron
WITHIN: brain
pituitary
ORGANISM: mammal*
unspecified cell type
WITHIN: spleen
MOTIF: exoplasmic domain {1-118}
MOTIF: signal sequence {1-17}
N-glycosylation site {N41}
N-glycosylation site {N74}
N-glycosylation site {N86}
N-glycosylation site {N94}
transmembrane domain {119-139}
cytoplasmic loop {140-148}
transmembrane domain {149-168}
exoplasmic loop {169-185}
transmembrane domain {186-209}
cytoplasmic loop {210-223}
transmembrane domain {224-245}
exoplasmic loop {246-264}
transmembrane domain {265-287}
cytoplasmic loop {288-310}
transmembrane domain {311-330}
exoplasmic loop {331-345}
transmembrane domain {346-365}
cytoplasmic domain {366-411}
Database Correlations
OMIM 602034
UniProt Q13324
PFAM correlations
Entrez Gene 1395
Kegg hsa:1395
References
UniProt :accession Q13324