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cAMP-responsive element modulator (CREM)

Like CREB, CREM binds to CRE & to AP1 sites. In contrast to CREB, CREM down regulates cAMP-induced transcription. Also in contrast to CREB, expression is cell-specific. May form heterodimers with other CRE-binding proteins.

Related

cAMP-responsive element [CRE] modulator (CREM) gene

Specific

cAMP-responsive element modulator [CREM]-alpha cAMP-responsive element modulator [CREM]-beta cAMP-responsive element modulator [CREM]-gamma cAMP-responsive element modulator [CREM]-tau inducible cAMP early regulator (iCER) S-CREM

General

cAMP-responsive element [CRE]-binding protein (CREB) phosphoprotein

Properties

COMPARTMENT: cell nucleus MOTIF: basic DNA-binding motif leucine zipper FOR-BINDING-VIA: leucine zipper S/T phosphorylation site

Database Correlations

OMIM 123812

References

  1. Foulkes NS, Borrelli E, Sassone-Corsi P. CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription. Cell. 1991 Feb 22;64(4):739-49. PMID: 1847666
  2. Foulkes NS, Laoide BM, Schlotter F, Sassone-Corsi P. Transcriptional antagonist cAMP-responsive element modulator (CREM) down-regulates c-fos cAMP-induced expression. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5448-52. PMID: 1647033
  3. Stehle JH et al Adrenergic signals direct rhythmic expression of transcriptional repressor CREM in the pineal gland. Nature. 1993 Sep 23;365(6444):314-20. PMID: 8397338