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cyclic AMP-responsive element-binding protein 3; Luman protein; transcription factor LZIP-alpha (CREB3, LZIP)
Function:
1) binds to & requires HCFC1 as a coactivator
2) activity & expression are suppressed when HCFC1-CREB3 complex binds ZF
3) LKN-1 induced chemotaxis signaling
4) interacts with CCR1, HCFC1, HCV core protein
Structure: N-glycosylated
Compartment:
- endoplasmic reticulum
- upon activation, proteolysis cleaves N-terminal cytoplasmic domain (40 kD) that translocates into the nucleus
Alternative splicing: named isoforms=2
Expression: ubiquitous
General
cAMP-responsive element [CRE]-binding protein (CREB)
Properties
SIZE: MW = 44 kD
entity length = 395 aa
COMPARTMENT: cytoplasm
endoplasmic reticulum
MOTIF: transcriptional activation domain
SITE: 1-92
DNA-binding motif
SITE: 179-196
leucine zipper
SITE: 207-237
FOR-BINDING-VIA: leucine zipper
transmembrane domain {255-271}
proteolytic site {290-291}
N-glycosylation site {N331}
proline-rich region
SITE: 340-385
MOTIF: proline residue (SEVERAL)
N-glycosylation site {N372}
Database Correlations
OMIM 606443
UniProt O43889
Pfam PF00170
References
UniProt :accession O43889