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creatine kinase

Function: - serves to create energy stores in the form of phosphocreatine in tissues that consume ATP ATP + creatine ADP + phosphocreatine Structure: - dimer of identical or non-identical chains - MM being the major form in skeletal muscle (98-99%) & myocardium (60%) - MB exists in myocardium (40%), skeletal muscle (1%) - BB existing in many tissues, especially brain (90%) - mitochondrial creatine kinases a) sarcomeric/mitochondrial creatine kinase b) ubiquitous/mitochondrial creatine kinase Compartment: - found associated with myofibrillary structures

Interactions

molecular events

Related

creatine kinase (CK) in serum creatine kinase gene

Specific

creatine kinase BB creatine kinase MB creatine kinase MM sarcomeric/mitochondrial creatine kinase (S-mtCK, CKMT2) ubiquitous/mitochondrial creatine kinase (U-mtCK, CKMT1, CKMT1A, CKMT, CKMT1B, Mia-CK)

General

kinase or ATP-phosphotransferase multisubunit protein

Properties

COMPARTMENT: cytoplasm MOTIF: kinase domain MOTIF: ATP-binding site NAME: ATP-binding site SUBUNITS: creatine kinase M subunit MOTIF: ATP-binding site NAME: ATP-binding site SITE: 128-132 ATP-binding site NAME: ATP-binding site SITE: 191-191 cysteine residue {C283} ATP-binding site NAME: ATP-binding site SITE: 292-292 ATP-binding site NAME: ATP-binding site SITE: 320-325 ATP-binding site NAME: ATP-binding site SITE: 335-335 creatine kinase B subunit MOTIF: Tyr phosphorylation site {Y39} Tyr phosphorylation site {Y125} ATP-binding site NAME: ATP-binding site SITE: 128-132 Ser phosphorylation site {S164} ATP-binding site NAME: ATP-binding site SITE: 191-191 cysteine residue {C283} ATP-binding site NAME: ATP-binding site SITE: 292-292 ATP-binding site NAME: ATP-binding site SITE: 320-325 ATP-binding site NAME: ATP-binding site SITE: 335-335 GENE: creatine kinase gene MISC-INFO: INHIBITOR = ADP INHIBITOR = URATE INHIBITOR = CYSTINE INHIBITOR = MN+2 INHIBITOR = CA+2 INHIBITOR = ZN+2 INHIBITOR = CU+2 lifetime 15 HOURS {1/2-LIFE}

Database Correlations

ENZYME 2.7.3.2

References

  1. Teitz, Fundamentals of Clinical Chemistry, 3rd ed, WB Saunders, Philadelphia, pg 375
  2. Clinical Diagnosis & Management by Laboratory Methods, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1991, pg 273
  3. Wikipedia: Creatine kinase entry http://en.wikipedia.org/wiki/Creatine_kinase

Components

creatine kinase B subunit (CKB) creatine kinase M subunit (CKM)