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cellular retinoic acid-binding protein 2; cellular retinoic acid-binding protein II; CRABP-II (CRABP2)
Function:
- transports retinoic acid to the nucleus
- regulates access of retinoic acid to nuclear retinoic acid receptors
- interacts with RXR & RARA (putative)
- interacts with importin alpha
Structure:
- forms a beta-barrel structure that accommodates hydrophobic ligands in its interior
- belongs to the calycin superfamily, fatty-acid binding protein (FABP) family
Compartment:
- cytoplasm, nucleus
- upon ligand binding, a conformation change exposes a nuclear localization motif & the protein is transported into the nucleus
Expression: induced by retinoic acid
General
fatty acid/retinol binding protein family
Properties
SIZE: entity length = 138 aa
MW = 16 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: peptide motif {21-31}
Retinoic acid binding {133-135}
Database Correlations
OMIM 180231
UniProt P29373
Pfam PF00061
Entrez Gene 1382
Kegg hsa:1382
References
- UniProt :accession P29373
- Ross AC.
Cellular metabolism and activation of retinoids: roles of
cellular retinoid-binding proteins.
FASEB J. 1993 Feb 1;7(2):317-27. Review.
PMID: 8440409