complexin-2; complexin II; CPX II; synaphin-1 (CPLX2)

Function: - positively regulates a late step in synaptic vesicle exocytosis - also involved in mast cell exocytosis (putative) - binds to the SNARE core complex containing SNAP25, VAMP2 & STX1A (putative) Structure: belongs to the complexin/synaphin family Compartment: - cytoplasm, cytosol - enriched at synaptic-releasing sites in mature neurons (putative) Expression: - nervous system - in hippocampus & cerebellum, expressed mainly by excitatory neurons Pathology: - down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression - down-regulated in cerebellum from patients with schizophrenia

General

complexin (synaphin) phosphoprotein

Properties

SIZE: entity length = 134 aa MW = 15 kD COMPARTMENT: cytoplasm MOTIF: coiled coil {28-84} SNARE complex interaction {41-97} MOTIF: Ser phosphorylation site {S93}

Database Correlations

OMIM 605033 UniProt Q6PUV4 Pfam PF05835 Entrez Gene 10814 Kegg hsa:10814

References

UniProt :accession Q13329