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complexin-1; complexin I; CPX I; synaphin-2 (CPLX1)
Function:
- positively regulates a late step in synaptic vesicle exocytosis
- also involved in glucose-induced secretion of insulin by pancreatic beta-cells (putative)
- binds to the SNARE core complex containing SNAP25, VAMP2 & STX1A (putative)
Structure: belongs to the complexin/synaphin family
Compartment:
- cytoplasm, cytosol (putative)
- enriched at synaptic-releasing sites in mature neurons
Expression:
- expressed in nervous system
- in hippocampus & cerebellum, expressed mainly by inhibitory neurons
Pathology:
- overexpressed in substantia nigra from patients with Parkinson disease
General
complexin (synaphin)
Properties
SIZE: entity length = 134 aa
MW = 15 kD
COMPARTMENT: cytoplasm
MOTIF: coiled coil {29-69}
SNARE complex interaction {48-70}
Database Correlations
OMIM 605032
UniProt O14810
Pfam PF05835
Entrez Gene 10815
Kegg hsa:10815
References
UniProt :accession O14810