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phospholipase-A2 [PLA2] type 4; cytoplasmic phospholipase A2 (cPLA2)
Function:
- marked preference for sn-2 arachidonate in phospholipid
- Ca+2-dependent phosphorylation & activation by MAP kinase (3)
Compartment:
- cytoplasm
- Ca+2-binding translocates cytoplasmic PLA2 to membrane
Specific
cytosolic phospholipase A2; phospholipase A2 group IVA; includes: phospholipase A2; phosphatidylcholine 2-acylhydrolase; lysophospholipase (PLA2G4A, PLA2G4)
General
Ca+2 binding protein
phospholipase A2; phosphatidylcholine 2-acylhydrolase (PLA2)
phosphoprotein
Properties
SIZE: calculated = 85 kD
MW = 95-110 kD
COMPARTMENT: cytoplasm
MOTIF: active site
MOTIF: histidine residue
cysteine residue (SEVERAL)
aspartate residue
cysteine-rich region
Ca+2-binding site
Ser phosphorylation site
FOR-PHOSPHORYLATION-BY: MAP kinase
binding site
FOR-BINDING-OF: phospholipid
binding site
FOR-BINDING-OF: G-alpha
MISC-INFO: Kd [Ca+2] 300-700 NM
Database Correlations
OMIM 600522
MORBIDMAP 600522
Entrez Gene 5321
References
- Liscovitch M.
Crosstalk among multiple signal-activated phospholipases.
Trends Biochem Sci. 1992 Oct;17(10):393-9. Review.
PMID: 1455508
- Glaser KB, Mobilio D, Chang JY, Senko N.
Phospholipase A2 enzymes: regulation and inhibition.
Trends Pharmacol Sci. 1993 Mar;14(3):92-8. Review.
PMID: 8488570
- Clark EA & Brugge JS
Integrins and signal transduction pathways: the road taken.
Science 268:233 1995
PMID: 7716514