chromosomal passenger complex (CPC)

Function: - regulator of mitosis - functions at the centromere in ensuring correct chromosome alignment & segregation - required for chromatin-induced microtubule stabilization & spindle assembly - cells lacking CDCA8 display a slight decrease in histone H3 Ser-10 phosphorylation, suggesting that the CPC complex mediates phosphorylation of Ser-10 of histone H3 Structure: - subunits: - BIRC5/survivin, CDCA8/borealin, INCENP & AURKB/Aurora-B

Properties

SUBUNITS: NIL

References

UniProt :accession O15392