cyclooxygenase (prostaglandin endoperoxide synthase, COX)

Aspirin acetylates & irreversibly inactivates the enzyme. Other non-steroidal anti-inflammatory agents bind non-covalently to the enzyme & inhibit its activity. Ceramide may activate cyclooxygenase.

Related

ceramide cyclooxygenase cascade cyclooxygenase gene prostaglandin [PG] synthase

Specific

cyclooxygenase-1 (COX1, PGH synthase-1, prostaglandin endoperoxide synthase-1, PTGS1) cyclooxygenase-2 (COX2, PGH synthase-2, prostaglandin endoperoxide synthase-2)

General

dioxygenase membrane protein

Properties

COMPARTMENT: cellular membrane MOTIF: membrane region active site allosteric site MISC-INFO: INHIBITOR = NON_STEROIDAL_ANTI_INFLAMATORY_AGENT