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COVID-19

Introduction: - information on this topic is continuously evolving, highlights below - coronavirus first noted to have caused pneumonia in Wuhan City, China - see SARS-CoV2 for information on COVID-19 variants Etiology: - SARS-CoV2 Epidemiology: - see SARS Cov2 epidemiology Pathology: - age & health of person & size of inoculum factors in severity of infection [365] - susceptibility to SARS Cov2 associated with: - lower levels of interferon type 1 response in the nose [255,365] - lower levels of HLA-DQA2 on antigen-presenting cells in both blood & nasal mucosa [365] - spike glycoprotein on SARS CoV-2 binds to human cell surface receptor ACE2 expressed on epithelial surfaces - nasal epithelium - ACE2 expression in nasal epithelium lowest in children < 10 years of age [221] - salivary glands pharynx are major sources of coronavirus replication [256] - lung alveolar epithelial cells (pneumocytes) - myofiber membrane of the diaphragm muscle [267] - the spike glycoprotein* requires a transmembrane serine protease TMPRSS2 expressed on type II pneumocytes as well as non-respiratory cells in order for the virus to enter a cell [301] - the TMPRSS2 cut exposes a run of hydrophobic amino acids that rapidly buries itself in the closest membrane, the host cell membrane - the extended spike glycoprotien folds back onto itself, like a zipper, forcing the viral & cell membranes to fuse - SARS-CoV2 then ejects its genome directly into the cell - cathepsin-L provides an alternate route for the virus to enter a cell - inside the cell, SARS-CoV2 is translated into non-structural proteins that suppress translation of host mRNA in favor of viral RNA - viral protein NSp1, one of the 1st translated viral proteins, recruits host ribonucleases to systematically cleave all cellular mRNAs without a viral tag - SARS-Cov2 transforms the host cell endoplasmic reticulum into double membrane vesicles where viral replication occurs - T-cells block replication of SARS-CoV2 by disabling replication transcription complex, which facilitates viral replication [314] - double membrane vesicles fuse with Golgi &/or lysozymes & subsequently cell membrane - host furin cleaves the spike glycoprotein at a site of 5 amino acids prior to cell membrane fusion & release from the cell facilitating the next entry of the virus into a new cell - initial proline amino acid change (P681R) in the spike glycoprotein 5 amino acid sequence recognized by furin in the delta variant further enhances next cell infectivity [301] - as patients get sicker, SARS CoV-2 migrates from the nasopharynx to the oropharynx & into the lower respiratory tract - as it migrates down, it is unknown whether it leaves the nasopharynx [123] - coinfection with other respiratory pathogens common - 21% with rhinovirus/enterovirus &/or respiratory syncytial virus [143] - bacterial superinfection found in 21% of patients [313] - use of dexamethasone & pulmonary infarction contribute [345] - endothelial injury, vascular thrombosis, microangiopathy, angiogenesis [223,261] - endothelial dysfunction can lead to ischemic stroke & hemorrhagic stroke [302] - activated neutrophils & platelets play roles in the immunologically mediated thrombosis associated with severe COVID-19 [197] - upregulation of neutrophil activation marker CD177 in severe COVID-19 [197] - intense formation of neutrophil extracellular traps, leading to occlusion of microvessels, especially in lung & in coronary arteries during STEMI [99] - lupus anticoagulant associated with thrombosis (RR=4.4) [179] - autopsies show little evidence of inflammation or direct viral cytopathology outside the respiratory tract [347] - SARS CoV2 directly infects atherosclerotic plaques in the coronary arteries, resulting in a persistent inflammatory response [356] - inflammatory cell infiltration of the nasal & olfactory mucosa - intracytoplasmic viral inclusion bodies in the olfactory bulb [195] - olfactory bulb may show astrocytosis & microgliosis [263] - many patients have severe hypoxemia, but respiratory compliance - ability of the lung to expand with inhalation - frequently remains normal [167] - hypoxemia without dyspnea suggested due to ventilation-perfusion mismatch, a result of vascular pathology (pulmonary vessel dilatation & pulmonary capillary deformation) [172,217] - SARS CoV-2 found not only in upper & lower respiratory tract, but also in GI tract, heart, & on autopsy in liver, kidneys & brain [207] - SARS-CoV2 RNA found in human cornea [288] - COVID-19 may cause myocarditis & elevated serum troponin-I via SIRS [189] - SARS-CoV-2 commonly detected in brains of patients, but no evidence of damage [347] caused directly by the virus [263,290] but may result from thromboembolism - brain edema, astrocytosis & gliosis, micro infarcts not uncommon [263] - microglial activation were most pronounced in the brainstem & meninges [263] - megakaryocytes found in cortical capillaries of 5 people who died of COVID-19 [209] - no evidence of SARS-CoV-2 in the brain at the time of autopsy [302] - altered gene expression in glial cells (innate immune cells of the brain) & cells of the choroid plexus involved in the blood-brain barrier [302] - thus SARS-CoV2 may send signals through the blood-brain barrier to activate the brain's immune system [302] - gene expression patterns similar to patterns in patients with dementias &/or schizophrenia [302] - synaptic signaling impaired in excitatory neurons involved in cognition [302] - complement-mediated antibody-activated cytotoxicity directed against endothelial cells initiates vascular leakage, platelet aggregation, neuroinflammation & neuronal injury [332] - the pattern of gene expression in the frontal cortex of younger patients with severe Covid-19 resembles gene expression in uninfected elderly [346] - the genes expressed reflect a cellular response to DNA damage, inflammation, mitochondrial dysfunction, oxidative stress, & altered insulin signaling [346] - diffuse alveolar damage & SARS-CoV-2 persistence in the respiratory tract identified as the predominant histopathologic findings & leading cause of death [229] - respiratory failure or heart failure most common cause of death [284] - in the innate immune repsonse of respiratory epithelial cells, ssRNA of SARS-CoV-2 is recognized by TLR7 within endosomes, leading to induction of cytokines & IFN [63] - plasma levels of proinflammatory cytokines TNF, IL-6, & IL-8 less than with septic shock or ARDS in ICU patients with COVID-19 [219] - in most infections, the immate immune response is sufficient to clear the virus & prevent severe disease [63] - if the innate immune response does not clear the virus, an overactive immune response may ensue & result in collateral inflammatory damage [63] - immune response may be less in asymptomtatic vs symtomatic patients [268] - patients with more-severe COVID-19 - mount stronger Ab responses to SARS-CoV2 - mount weaker Ab responses to other common respiratory viruses (including common coronaviruses) [242] - more likely to harbor cytomegalovirus & herpes simplex virus 1 [242] - immunologic memory protects against severe disease & death [311] - memory T cells & memory B cells persist for at least 6-8 months after Covid-19 infection & continue to evolve & mature; this is not assessed by an antibody test [311] - spike protein-specific memory B cells higher at 4-6 months in most recovered patients, & continue to strengthen & mature for at least 12 months [260] - quiescent spike protein-specific bone marrow plasma cells recovered 8 months after COVID-19 infection suggesting long-lived immunity [260] - T-cell activity & immunity against SARS-CoV2 found in children with primary immune deficiencies after vaccination [260] - immunity after COVID-19 infection for at least 1 year strengthened by vaccination providing resistance to variants of concern including B.1.617.2 (delta) [299] - mutations in IFN-alpha pathway genes more common in patients with severe COVID-19 [255] - auto-antibodies to IFN-alpha in 10% of patients with severe COVID-19 [255] - auto-antibodies to IFN type 1 account for both critical cases of COVID-19 in elderly > 80 years & total COVID-19 mortality [305] - auto-antibodies to IFN type 1 are present in 0.18% of persons 18-69 years, 1.1% of persons 70-80 years & 3.4% of persons > 80 years [305] - women mount a stronger immune response to SARS-CoV-2 than men [202] - women produce more T-cells than men in response to the virus [202] - women produce less Ab response to SARS-CoV2 than men [242] - older age associated with lower T-cell response in men but not women [202] - transplacental transfer of maternal antibodies to SARS-CoV-2 is inefficient [115] - minor lung inflammation may occur in many asymptomatic patients [268] - butyric acid-producing bacteria are decreased & lipopolysaccharide-producing bacteria are increased in Covid-19 patients [287] - during recovery, 47 lipids, including sphingomyelin & monoglyceride are depleted, 122 lipids, including phosphatidylcholine, phosphatidylethanolamine & diglyceride are enriched in oral cavity [287] - gut microbiota composition reflects disease severity & dysfunctional immune response - Faecalibacterium prausnitzii & Eubacterium rectale diminished in COVID-19 [123] - SARS-CoV-2 infects human adipose tissue & elicits an inflammatory response [315] - inhibition or knockout of GRP78 suppresses SARS-Cov2 replication & infectivity [344] * 3D structure of spike glycoprotein [122] Genetics: viral genetic factors - see SARS-CoV2 human genetic factors - apo e4 allele confers risk for COVID-19 (RR=2.3-2.4) [231] - 3p21.31 gene cluster is a genetic susceptibility locus for Covid-19 respiratory failure [264] - locus 3p21.31 region contains LZTFL1 gene that may regulate epithelial-mesenchymal transition in pulmonary epithelial cells in COVID-19 [318] - linked to the ABO blood group system - the receptor binding domain (RBD) of SARS-CoV2 bears sequence & overall ABO blood binding similarity with human galectins [352] - SARS-CoV2 preferentially infects blood group A cells, linking expression of blood group A expression with increased risk of infection [352] - persons with blood type A or blood type B may be more susceptible to COVID-19 than persons with blood type O [242,264] - compared with type O blood, type A is not associated with increased SARS-CoV2 infection, hospitalization, or ICU admission [258] - types B & AB are not associated with worse outcomes than type O [258] - the SARS-CoV2 receptor binding domain preferentially recognizes blood group A antigen expressed on respiratory epithelial cells [264] - persons with blood type O or Rh-negative blood may be slightly less susceotible to COViD-19 [264] - ability to taste bitterness via T2R38 associated with enhanced innate immunity to SARS-Cov2 [295] - putative loss-of-function variants of X-chromosomal TLR7 associated with impaired IFN response identified in young men with severe COVID-19 [63] - mutations in IFN-alpha genes in 3,5% of patients with severe COVID-19 [255] - mutations in IFN-alpha pathway genes more common in patients with severe COVID-19 [255] - Can SARS CoV2 RNA genes insert into human DNA? (see SARS-CoV2) Clinical manifestations: - median incubation period is 4-5 days [64,105]; range: 2-12 days [80], 2-7 days [105] - symptom rebound occurs in 26% of patients a median of 11 days after symptom onset - rebound lasts 1 day in 89%, 5% are hospitalized [350] - virologic rebound - occurs in ~20% of patients who receive Paxlovid vs < 2% in those who do not [362] - occurs in 27% of paxlovid treated vs. 7% of untreated patients [361] - no relationship between previous treatment with antiviral & Covid-19 rebound [360] - most people with the Omicron variant (56%) are unaware that they have it [336] - most common symptoms [310] - sore throat is becoming a dominant symptom in the Omicron period [338] - anosmia & dysgeusia may be early signs of COVID-19 [91] - anosmia may occur in > 60% [232]; generally resolves within weeks [91 - fever* (40%-90%), chills - median duration of fever in all patients with fever is 10 days (95% CI* 8-11 days) after onset of symptoms [105] - ICU patients with significantly longer duration of fever (31 days vs 9 days) after onset of symptoms [105] - cough*, dyspnea*, sputum production (30%) - myalgia, fatigue, anorexia [12] - sore throat 58%, headache* 49%, cough without phlegm 40%, nasal congestion 40% rhinitis 40%, cough with phlegm 37%, hoarse voice 35%, sneezing 32% are the most common symptoms reported during Omicron predominance in 2022 & 2023 [335] - can present as common cold [66] - runny nose, sore throat - night sweats associated with Omicron infection, especially BA.5 [333] - in children, anosmia/ageusia, nausea/vomiting, headache & fever most common - ~2/3 of children who test positive report symptoms [272] - children < 5 years infected with Omicron variant may present with symptoms of croup with barking cough [320] - pulmonary symptoms may include chest pain or pressure - bronchospasm is uncommon & generally due to pre-existing pathology - dyspnea is most common end-of-life symptom [284] - GI symptoms in 12% [254] - anorexia, diarrhea (7%), nausea/vomiting (5%) & abdominal pain (4%) [140,215,254] - fever common with GI symptoms, cough less common [140] - neurological symptoms in older sicker patients [132] - headache (tension headache vs migraine) predicts clinical course - headache associated with shorter symptomatic period [285] - acute cerebrovascular disease, impaired consciousness, encephalophy [263] - COVID-19 may present as breakthrough seizure(s) in patients with epilepsy [168] - new onset confusion, altered mental status [CDPH] - brain fog, new-onset anxiety, depression, psychosis [233] - confusion/delirium may be presenting symptom in elderly patients [174] - cyanosis of lips &/or face [CDPH] - chilblain-like lesions on toes (COVID toes) seen largely in younger patients including children with benign clinical course) [185] - heterogeneity of skin lesions may or may not be due to SARS CoV2 [186,280] - ocular manifestations (epiphora, conjunctival congestion, chemosis) occur in < 1/3 of patients. most commonly in patients with more severe disease [208] - elderly may present with atypical signs/symptoms [173] - hyperglycemia on hospital admission predicts severity & mortality (RR=2) [273] - symptom recurrence common after 2 consecutive symptom-free days [340] * CI: confidence interval * fever, cough & dyspnea 3 most common signs/symptoms [142] * headache among inpatients may be a marker of enhanced survival [339] Laboratory: - see SARS Cov2 laboratory Special laboratory: - bedside lung ultrasound - right ventricular hypertrophy may result from pulmonary artery hypertension due to pulmonary artery thrombosis [214] - may be useful in determining which patients need hospitalization [92] - echocardiogram - right ventricular dilation & left ventricular diastolic dysfunction are the most common fundings [251] - electrocardiogram [225] - bronchoalveolar lavage might minimize empirical broad-spectrum antibiotics [313] - dogs can sniff out Covid-19 (see screening for Covid-19) - olfactory testing (see screening for Covid-19) Radiology: - indications: [161] - imaging (chest X-ray vs CT of lungs) recommended for patients with moderate-severe symptoms & for patients whose symptoms progress. - imaging findings can be used for triage when testing is unavailable or unreliable, or when results may be delayed by several hours or days - imaging is not recommended for patients with mild symptoms, unless high likelihood of disease & risk factors for disease progression - bilateral pulmonary infiltrates on chest X-ray - CT of lungs: - ground-glass opacification - mixed ground-glass opacification & consolidation [47] - extensive multifocal involvement [97] - abnormalities bilateral in 86% of cases - lesions particularly evident in lower lobes, posterior lung fields, & peripheral lung zones [97] - consolidation generally occurs later than ground glass opacities - pleural effusion uncommon (8%) [97] - useless for COVID-19 diagnosis [158] - CT imaging findings may persist at 3 months & 1 year after Covid-19 [331] - ground-glass opacities & curvilinear bands most common - no correlation of long Covid-19 symptoms & persistent imaging findings [331] - brain MRI: - encephalopathy, corticospinal tract signs, & frontotemporal hypoperfusion commonly observed in the absence of detectable virus in CSF [188] - high-resolutution MRI shows microvascular brain injury in deceased COVID-19 patients with thinning & leaky brain blood vessels without signs of SARS-CoV2 brain tissue infection [105] - echocardiography abnomralities in 1/2 of Covid-19 patients [151,251] Differential diagnosis: - see common cold vs influenza vs Covid-19 Complications: - acute respiratory distress syndrome (ARDS) (30% of symptomatic cases) - extreme air hunger may ocuur in mechanically ventilated patients [243] - 20% of patients show evidence of early bacterial pneumonia [313] - < 50% of patients develop ventilator-associated pneumonia [313] - ventilator-associated pneumonia in patients with Covid-19 higher than other causes of ARDS [345] - frequently associated with treatment failure, recurrences, abscesses, empyema [345] - pulmonary fibrosis [274] - cardiomyopathy - acute cardiac injury (12% of symptomatic cases) - ST segment elevation myocardial infarction (STEMI) [147] - ICU admission associated with increased risk of cardiac arrest (RR=4.7) [271] - 60% with cardiac inflammation by MRI 7 days after positive test [164] - few cases of inflammatory heart disease after COVID-19 detected in professional athletes, thus safe to return to play [215] - post COVID-19 heart failure predicted by editorialist [164] - QTc prolongation in hospitalized patients [289] - large vessel stroke reported in patients < 50 years [170] - higher incidence of autoimmune inflammatory rheumatic diseases among patients with a history of COVID-19 [363] - secondary infection (10% of symptomatic cases) - mortality of hospitalized patients with comorbid COVID-19 & fungal infection is 48% vs 12% for Covid-19 alone [353] - aspergillosis, invasive candidiasis, mucormycosis, other mycoses linked to most fungal infection-associated deaths [353] - ~15% of patients with COVID-19 hospitalized in an ICU develop Aspergillosis [312] - hospitalized patients with increased risk for myocardial infarction (RR=10), stroke (RR=18), atrial fibrillation (RR=15), heart failure (RR=22), pericarditis (RR=14) within 5 months [341] - risks highest in 1st 30 days [341] - risks for death & adverse medical &/or mental health sequelae after hospitalization for COVID-19 are <= risks after hospitalizations for influenza or sepsis [355] - exception: Covid-19 confers excess risk for venous thromboembolic disease === COVID-19 deaths === - 3rd leading cause of death in the U.S. in 2020 & 2021 [242,328] (CDC) - deaths attributed to COVID-19 accounted for 72.4% of US excess deaths [328] - 30 day mortality for hospitalized veterans with COVID-19 vs influenza: RR=6.6 [327] - COVID-19 death estimates variable (15%) [12]; 2.2% [15] - may be < 1% [58] of symptomatic cases - overall COVID-19 infection fatality rate 0.5-1% [262] - COVID-19 fatality is 0.26% among noninstitutionalized persons >= 12 years [262] - COVID-19 fatality is 5 times that of seasonal influenza [110] - COVID-19 fatality is age & race-dependent - COVID-19 fatality is 1.71% among those >= 60 years - vs fatality of 0.8% among those >= 65 years for seasonal influenza [262] - COVID-19 fatality is 0.59% among non-whites - Up to 90% mortality in intubated patients in New York City [157] - 1/3 of hospitalized COVID-19 patients may die (early estimate) [183] - 30 mortality after hospitalization for Covid-19 Oct 1, 2022 to Jan 31, 2023, 6.0% vs 3.8% for influenza [351] - median time from disease onset to death is 16 days [112] - deceased patients, compared with patients who recovered, were older (age, 68 vs 51), more likely to be male (73% vs 55%), & more likely to have chronic hypertension & cardiovascular disease (48% vs 14%) [112] - frailty is a risk factor for Covid-19 mortality (RR=1.9) [307] - dementia is a risk factor for Covid-19 mortality [354] - deceased patients were more likely to have leukocytosis (50% vs 4%) & lymphopenia (91% vs 47%) [112] - LFTs, serum creatinine, serum lactate dehydrogenase, serum troponin-I, serum N-terminal pro-BNP. plasma d-dimer, & systemic inflammatory marker levels were much higher in deceased patients than in those who recovered - ARDS (100%), sepsis (100%), acute cardiac injury (77%), heart failure (49%), acute kidney injury (25%), & encephalopathy (20%) were much more common in deceased patients [112] - high vs low physical activity reduces risk of death 42% [326] - even moderate exercise (> 150 minutes/week) reduces risk of death 21% [326] - increased risk of death within 5 months [341] - RR=10 non-hospitalized, RR-118 hospitalized - US reported 370,298 deaths due to Covid-19 (112/100,000) during the Delta & Omicron waves (61/100,000 Delta wave) & (51/100,000 Omicron wave) exceeding death rates in 20 peer countries [343] - the 10 states with most-vaccinated persons had excess all-cause mortality <= to Denmark, Germany, the Netherlands, Austria, Italy, & Finland [343] - 6% of adults >=50 years progress to severe, critical or fatal disease - risk varies minimally with age & gender, but increases with comorbidities, & decreases with vaccination, more so with Covid-19 vaccine booster [357] * Online tool estimates COVID-19 mortality risk [83] === Major adverse cardiac events including Cardiopulmonary arrest === - acute & chronic risk of major adverse cardiovascular events [370] - few COVID-19 survivors of in-hospital cardiac arrest [211,230] - none in one study, 7% with normal to mildly impaired neurologic function in larger study - non-shockable rhythms common, usually pulseless electrical activity [230] - return of spontaneous circulation in out-pf-hospital cardiac arrest lower during the COVID-19 pandemic [257] - risk of myocardial infarction & stroke elevated post-hospitalization for 3 years (RR=3.8) particularly in non-O blood types [370] === Coagulopathy & hyperviscosity === - Coagulopathy with arterial thromboemolism & venous thromboembolism - coagulopathy & antiphospholipid Ab in older man in China with a history of hypertension, diabetes, & stroke [128] - 29.4% of ICU patients with thrombosis - 13.6% venous thrombosis, 18.6% arterial thrombosis [119] - 11.5% of non ICU hospitalized patient with thrombosis - 3.6% venous thrombosis, 8.4% arterial thrombosis [119] - venous thromboembolism: 4.8% overall, 7.6% in critically ill patients & 3.1% in non-critically ill patients [194] - arterial thromboembolism: 2.8% overall, 5.6% in critically ill patients 7 1.2% non-critically ill patients [194] - Thrombosis predicted by elevated D-dimer level at admission (>2500 ng/mL) [194] - major bleeding: 2.3% overall, 5.6% in critically ill patients [194] - deep vein thrombosis discovered in 58% of COVID-19 autopsies [193] & in 79% of ICU patients [237] - disseminated intravascular coagulation on day 4 with worseninng days 10-14 [134] - obstruction of pulmonary arteries by thrombosis (macroscopic & microscopic) in > 90% of patients (on autopsy) despite anticoagulation frequently associated with pulmonary infarction & bronchopneumonia [214] - venous thromboembolism risk not increased in outpatients with COVID-19 [265] - venous thromboembolism risk is increased in ambulatory patients with COVID-19 [337] - 60 vs 2.4 per 1000 person-years with 30 days (RR=21) - risk attenuated in fully vaccinated with breakthrough infection (RR=6) - older age, male sex, & obesity associated with higher risk [337] - risk of cerebral venous thrombosis 100 fold greater than normal, several fold higher than post Covid-19 vaccination or following influenza [275] - excess risk for venous thromboembolism persists for months after Covid-19 [329] - risk greater for hospitalized patients [329] - high arterial blood viscosity is associated with ~60% increased risk for mortality among patients hospitalized with COVID-19 [334] - link between hyperviscosity & immune-mediated thrombosis of COVID-19 [334] - increased risks for venous thromboembolism within 5 months [341] - RR=2 for non-hospitalized, RR=28 for hospitalized [341] - venous thromboembolism recurrence rate (5/100 patient-years) after discontinuation of anticoagulation (no deaths observed) [342] === Neuropsychiatric complications === - neurologic complications common - 42% at onset, 63% at hospital admission, 82% at any time of illness [236] - most common manifestations: myalgias, headaches, encephalopathy, dizziness, dysgeusia, anosmia [236] - seizures, ischemic stroke & encephalopathy in severely ill patients [236,266] - toxic metabolic encephalopathy is common & often lethal in hospitalized patients with COVID-19 [224] - neurological manifestations found in ~80% of hospitalized COVID-19 patients [293] - most common self-reported symptoms: headache (37%), anosmia or ageusia (26%) - most common neurological signs &/or syndromes: acute encephalopathy (49%), coma (17%). & stroke (6%) [293] - long-term neuropsychiatric complications common after hospitalization [111] - 39% of hospitalized patients, 50% after ICU admission [259] - cognitive deficits, hyposmia, & postural tremor most common [111] - intracranial hemorrhage; ischemic stroke; parkinsonism; Guillain-Barre syndrome; nerve, nerve root & plexus disorders; myoneural junction & muscle disease; encephalitis; dementia; psychotic, mood, & anxiety disorders; insomnia. - altered mental status - stroke in 2% of patients admitted to ICU [276,281] - hemorrhagic stroke was linked to higher mortality - ischemic stroke was not [276] - ischemic stroke often severe with poor outcome [159] - disorders of consciousness (20% of elderly with severe disease) [249] - encephalopathy or encephalitis often in younger patients [281] - cognitive dysfunction in sustained attention domain [115] - delirium median duration 3 days [114] - frailty is a risk factor for delirium [307] - use of benzodiazepines during mechanical ventilation independently associated with increased risk for delirium [114] - friend or family visitation (in person or virtual) reduces risk of delirium [114] - 82% of ICU patients comatose for median of 10 days [114] - Guillain-Barre syndrome [148] (1 case [249]); no association [277] - 1 in 5 cases of Guillain-Barre syndrome with prior Covid-19 [308] - acute myopathic quadriplegia in ICU patients [286] - acute necrotizing hemorrhagic encephalopathy (case report) [117] - stroke in 2% of patients admitted to ICU - hemorrhagic stroke was linked to higher mortality - ischemic stroke was not [276] - stroke risk highest in first 3 days after infection [323] - demyelination may occur [302] - peripheral nerve injury associated with severe Covid-19 === Other complications === - acute kidney injury in 34-50% of hospitalized patients, dialysis in 14% [241,294] - risk factors include mechanical ventilation, vasopressors, diuretics, elevations in inflammatory markers [294] - parenchymal infection of tubular epithelial cells & podocytes with acute tubular injury & RBC aggregation occurs in lethal COVID-19 [149] - gastrointestinal complications - mesenteric ischemia, ileus - pediatric multisystem inflammatory syndrome [190] - inflammation may involve the skin, eyes, blood vessels & heart. - thought to be a post-infectious immune response [190] - 80% of children admitted to ICU with underlying condition, most commonly immunodeficiency or cancer [190] - bears some resemblance to Kawasaki disease - Strongyloides hyperinfection syndrome in patients receiving dexamethasone with unrecognized underlying chronic infection with Strongyloides [175] - 3 cases of myasthenia gravis following SARS-CoV-2 infection in elderly [180] - thyroiditis [269] - postinfectious, immune-mediated myopathy [296] - inflammation of skeletal muscles associated with duration of illness - more pronounced than cardiac inflammation [296] - rhabdomyolysis [369] - Covid-19 is associated with an increased risk for a composite outcome of maternal mortality or serious morbidity from obstetric complications [321] - burnout among healthcare workers [306] - risk for postoperative complications remains elevated for 8 weeks after Covid-19 [324] - increased risk for diabetes mellitus within 90 days of Covid-19 (RR=2.35) [349] - Covid-19 vaccine reduces risk [349] - progression to diabetes mellitus type 1 accelerated after Covid-19 [366] - increased risk of diabetes mellitus type 2 [367] === Risk factors for poor outcomes === - Risk factors for symptomatic & severe disease (SARS) & death - older age (> 65 years)* [130] - male - COPD* & moderate-to-severe asthma [239] - obstructive sleep apnea [67] - cardiovascular disease [184] - heart failure 12% [213]; coronary artery disease [278] - immunodeficiency from solid organ transplantation [278] - hematopoietic stem cell transplantation (HSCT) [228] - cancer immunotherapy (~3-fold risk) [279] - HIV1 infection - systemic glucocorticoids not autoimmune disease a risk factor for poor outcomes [304] - obesity* [213,218], [278] (30%) & overweight [239], BMI > 23 mg/kg2 [292] - weight loss through bariatic surgery associated with improved outcomes in Covid-19 [319] - diabetes mellitus type 2 [213], [278] 20% - ~10% of COVID-19 patients with type 2 diabetes die within 7 days of hospital admission [240] - sitagliptin treatment at the time of hospitalization is associated with reduced mortality in patients with diabetes mellitus type-2 & COVID-19 [235] - diabetes mellitus type 1 [239] - chronic kidney disease [278] - end-stage renal disease: excess death for renal dialysis 2-3 fold higher than for renal transplantation [297] - sickle cell disease [303] - proton pump inhibitors (RR=2-4 for infection) [165] - other comorbidities [130]; - hypertension* most common comorbidity at Northern California Kaiser Permanente [169]; 26% [213] - cerebrovascular disease [278], stroke [239] - asthma does not seem to predict severe disease [145] - CDC says people with moderate to severe asthma may be at higher risk of getting very sick from COVID-19 [145] - eosinophilia in asthma is protective against severe COVID-19 [204] - smoking* [129]; vaping [125]; hospitalization 80% more likely for smokers [309] - cystic fibrosis [278] - other immunodeficiency (immunosuppressive agents, leukemia etc) [278] - HIV1 infection does not appear to influence risk of COVID-19 or outcomes in thosed infected with HIV1 (see HIV1/COVID-19 coinfection) - dementia & other neurologic conditions [278] - presentation with altered mental status [14] - neurological disability in multiple sclerosis [283] - nursing home residents with moderate-severe cognitive impairment [109] - Alzheimer's disease (RR=2) [181] - intellectual disabilities [220] - liver disease [239,278] - pregnancy [278] - pregnant women with COVID-19 face higher rates of adverse outcomes, including maternal mortality, preeclampsia, & preterm birth [316] - in women hospitalized for delivery, COVID-19 increased risk for preterm labor, preeclampsia, venous thromboembolism & mortality [176,252] - obesity, pregestational diabetes & hypertension increase risk of severe COVID-19 [252] - maternal SARS-CoV2 infection in pregnancy may be associated with small increases in some neonatal morbidities [291] - diabetes mellitus type 1 [278] - thalassemia [278] - psychiatric diagnosis for patients hospitalized with COVID-19 is linked to increase mortality [234] - substance abuse [239] - elective surgery during the incubation period of COVID-19 [126] largely due to pulmonary complications - independent risk factors of severe disease [198] - abnormal chest imaging - hemoptysis - dyspnea - unconsciousness - number of comorbidities - cancer history - leukemia, non-Hodgkin lymphoma, & lung cancer greatest risk [62] - CD20-targeting agents such as rituximab (Rituxan) & obinutuzumab (Gazyva) associated with severe COVID-19 in lymphoma patients [178] - active cancer chemotherapy may not be a risk factor for severe COVID-19 [178] - androgen-deprivation therapy does not reduce severity of Covid-19 [317] - neutrophil/lymphocyte ratio - serum lactate dehydrogenase - bilirubin conjugated in serum - inflammation through serum IL-6 & thromboses through plasma D-dimer predict death in ICU patients [216] - vitamin D deficiency associated with increased Covid-19 severity & mortality [322] - may reduce Covid-19 ICU admission/mortality (RR=0.32-0.41) when administered after diagnosis (dose, duration, & mode of administration unknown) [322,364] - vitamin D supplementation may reduce risk of Covid-19 infection (RR=0.40-0.59) [364] - risk stratification score for predicting in hospital mortality [226] - uses age, sex, comorbidities, respiratory rate, SaO2, Glasgow Coma Scale, serum urea, & serum C-reactive protein [226] - COVID-19 fatality ratio is 1.15% of all infected people in high-income nations & 0.23% in low-income nations [244] - risk factors in children & adolescents [298] - diabetes mellitus type 1, congenital heart disease, obesity ==== Risk factors in Nursing Home Residents ==== - risk of hospitalization - increased BMI, male sex, Black, Hispanic, Asian - impaired functional status - increased comorbidities: kidney disease, diabetes mellitus - risk of mortality - increased age. cognitive impairment, dementia [354], functional impairment === Not risk factors? === * Obesity, black race, bispanic ethnicity, COPD, hypertension, & smoking not associated with mortality in a Veterans Admniminstration study [222] === Persistent symptoms & late complications - long COVID-19 === - Persistent symptoms after COVID-19 common (see long Covid-19) - 90% of discharged COVID-19 patients report persistent symptoms 2 months later: Fatigue, dyspnea, arthralgia, & chest pain most common [160] - 75% have >= 1 persistent symptom 6 months after hospitalization [113] - fatigue or muscle weakness (63%) - sleep disorder (26%) - anxiety or depression (23%) [113] - during a mean 140 days after hospitalization for Covid-19 - 29% of patients were readmitted & 12% died [245] === Epidemiology === - patients age 60-69 years most common age group hospitalized (25%) & admitted to ICU (27%) at Northern California Kaiser Permanente [169]; proportion of younger adults hospitalized similar to proportion of older adults hospitalized === Survival among the very old === * Even very old people (supercentenarians) can survive COVID-19 [206] === reducing risk of complications === - high vs low physical activity reduces risk of complications [326] - 34% lower risk for hospitalization - 41% lower risk for ICU admission - 45% lower risk for requiring mechanical ventilation - 42% lower risk for death - even moderate exercise (> 150 minutes per week) reduces risk of complications [326] - 13% lower risk for hospitalization - 20% lower risk for ICU admission - 27% lower risk for requiring mechanical ventilation - 21% lower risk for death - physical activity before COVID-19 infection is associated with less severe outcomes [348] - higher cardiorespiratory fitness favorably impacts survival, hospitalization, & need for endotracheal intubation regardless of age, body mass index, or comorbidities [371] Management: - see COVID-19 management - prevention: - see COVID-19 vaccine - prevention after high-risk exposure: see casirivimab - prevention with Paxlovid - only thromboembolic events seem to be reduced by Paxlovid [358] - Paxlovid reduces incidence of long Covid-19 (absolute risk reduction = 4.5%) [359] - molnupiravir treatment for COVID-19 slightly lowers risk of long Covid-19 [359] - prevention with diet - high adherence to Mediterranean diet is a protective factor against COVID-19, - unclear benefits against COVID-19 symptoms & severity [368] Comparative biology: - experiments in mice: - candidate vaccine delivered via microneedle arrays elicited an immune response to SARS-CoV-2 in mice [121] - nasal spray that blocks absorption of SARS CoV2 completely protects ferrets from COVID-19 in a small study [248] - the nasal spray attaches to cells in the nose & lungs & lasts about 24 hours - the spray contains a lipopeptide that exactly matches a stretch of amino acids in the spike protein of the virus, which SARS CoV2 uses to attach to human airways - before SARS CoV2 can inject its RNA into a cell, the spike protein must effectively unzip, exposing two peptides (amino acid chains), in order to fuse to the cell wall. - before the spike protein is able to zip back up to complete the process, the lipopeptide in the spray inserts itself, latching on to one of the spike protein peptide chains preventing zipping the zipper & attachment of SARS CoV2 [248] - minks can transmit SARS-CoV-2 to humans [253] - gorillas at the San Diego Zoo Safari Park have tested positive for SARS-CoV2 - asymptomatic staff member may have transmitted the virus to the gorillas [134] - SARS-CoV2 induces brain inflammation in Rhesus macaques & African green monkeys [330] Notes: - allocation of resources may be affected by the COVID-19 pandemic [118] - discussed in updated references - CDC discusses COVID-19 & long-term care facilities - CDC discusses therapeutic options & potential therapies - asymptomatic critical infrastructure workers who have been exposed to SARS-CoV-2 may continue to work provided they remain asymptomatic & wear a face mask for 14 days since the last exposure (CDC) - virus surveillance & intermittent social distancing may have to continue until 2022 if treatment, vaccine, or contact tracing & quarantine are not effective [141] - following SARS CoV-2 in sewage may provide population prevalence of virus in watershed of sewage drainage [187] - Amabie - A Japanese Symbol of the COVID-19 Pandemic [127]

Interactions

disease interactions

Related

common cold vs influenza vs Covid-19 COVID-19: multisystem inflammatory syndrome (MIS-C, MIS-A) ICD10 codes associated with Covid-19 long Covid-19; post-acute sequelae of COVID-19 (PASC); post-Covid syndrome screening for COVID-19; screening for SARS-CoV2 severe acute respiratory syndrome coronavirus 2; SARS-CoV2; Wuhan coronavirus

Specific

Covid-19 reinfection

General

viral infection respiratory tract infection

References

  1. Paules CI, Marston HD, Fauci AS. Coronavirus Infections - More Than Just the Common Cold. JAMA. Published online Jan 23, 2020. PMID: 31971553 https://jamanetwork.com/journals/jama/fullarticle/2759815
  2. Centers for Disease Control & Prevention (CDC) CDC Health Alert Network January 8, 2020, 16 Outbreak of Pneumonia of Unknown Etiology (PUE) in Wuhan, China. https://emergency.cdc.gov/han/han00424.asp
  3. World Health Organization (WHO) Pneumonia of unknown cause - China Disease outbreak news. January 5, 2020 https://www.who.int/csr/don/05-january-2020-pneumonia-of-unkown-cause-china/en/
  4. World Health Organization (WHO) Emergencies preparedness, response. Disease outbreak news : Update. Jan 12, 2020 Novel Coronavirus - China https://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/
  5. World Health Organization (WHO) News Release. Jan 13, 2020 WHO statement on novel coronavirus in Thailand. https://www.who.int/news-room/detail/13-01-2020-who-statement-on-novel-coronavirus-in-thailand
  6. Centers for Disease Control & Prevention (CDC) CDC Health Update. Jan 17, 2020 Update and Interim Guidance on Outbreak of 2019 Novel Coronavirus (2019-nCoV) in Wuhan, China https://emergency.cdc.gov/han/han00426.asp
  7. Walker M First Case of Coronavirus Lands in U.S. - Novel virus detected in man from Washington state. MedPage Today. January 21, 2020 https://www.medpagetoday.com/infectiousdisease/publichealth/84458 - Johnson CK, Stobbe M US Gets First Case of Mysterious Chinese Coronavirus Medscape - Jan 21, 2020. https://www.medscape.com/viewarticle/924020 - Centers for Disease Control & Prevention (CDC) First Travel-related Case of 2019 Novel Coronavirus Detected in United States. CDC News Release. January 21, 2020 https://www.cdc.gov/media/releases/2020/p0121-novel-coronavirus-travel-case.html
  8. Cadal C, Stanway D China's Wuhan shuts down transport as global alarm mounts over virus spread. Reuters. January 21, 2020 https://www.reuters.com/article/us-china-health-transmission/china-virus-deaths-rise-to-nine-heightening-global-alarm-idUSKBN1ZL07C
  9. Hua J, Cadal C China heads into Lunar New Year on shutdown as virus spreads to Europe. Reuters. January 22, 2020 https://www.reuters.com/article/us-china-health/china-puts-millions-on-lockdown-as-virus-toll-rises-to-18-and-who-weighs-response-idUSKBN1ZM087?
  10. World Health Organization (WHO) News Release. Jan 23, 2020 Statement on the meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV). https://www.who.int/news-room/detail/23-01-2020-statement-on-the-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov)
  11. Young K As Novel Coronavirus Spreads, WHO Declines to Declare International Emergency Physician's First Watch, Jan 24, 2020 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org
  12. Zitser J Alarm over a new COVID-19 variant in the UK. Boris Johnson calls an emergency meeting to combat the mutating coronavirus. Business Insider, Dec 19, 2020 https://www.businessinsider.com/boris-johnson-holds-emergency-meeting-discuss-new-covid-19-strain-2020-12 - Berger M U.K. variant of coronavirus continues global spread, despite containment efforts. Washington Post. Dec 26, 2020 https://www.msn.com/en-us/news/world/uk-variant-of-coronavirus-continues-global-spread-despite-containment-efforts/ar-BB1cfzQm - Centers for Disease Control & Prevention (CDC) Implications of the Emerging SARS-CoV-2 Variant VOC 202012/01. COVID-19 (Coronavirua Disease) Dec. 22, 2020 https://www.cdc.gov/coronavirus/2019-ncov/more/scientific-brief-emerging-variant.html
  13. Centers for Disease Control & Prevention (CDC) CDC Situation Summary, Jan 26, 2020 2019 Novel Coronavirus (2019-nCoV), Wuhan, China https://www.cdc.gov/coronavirus/2019-ncov/summary.html
  14. George J Altered Mental State Tied to COVID-19 Mortality - In-hospital deaths higher, even when pulmonary problems were not severe. MedPage Today December 21, 2020 https://www.medpagetoday.com/infectiousdisease/covid19/90354 - Eskandar EN, Altschul DJ, de La Garza Ramos R et al Neurologic syndromes predict higher in-hospital mortality in COVID-19. Neurology 2020. Dec 18. PMID: 33443111 https://n.neurology.org/content/early/2020/12/17/WNL.0000000000011356
  15. Walker M 132 Dead as WHO Mulls Another Coronavirus Meeting - As cases pass 6,000, agency ponders whether to declare international health emergency. MedPage Today. January 29, 2020 https://www.medpagetoday.com/infectiousdisease/publichealth/84604
  16. Lu R, Zhao X, Li J et al Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020. Jan 30. PMID: 32007145 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30251-8/fulltext
  17. Chen N, Zhou M, Dong X et al Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020. Jan 30. PMID: 32007143 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30211-7/fulltext
  18. Li Q, Guan X, Wu P et al Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus - Infected Pneumonia N Engl J Med 2020. Jan 29 PMID: 31995857 https://www.nejm.org/doi/10.1056/NEJMoa2001316
  19. World Health Organization (WHO), Jan 30,2020 WHO Director-General's statement on IHR Emergency Committee on Novel Coronavirus (2019-nCoV). https://www.who.int/dg/speeches/detail/who-director-general-s-statement-on-ihr-emergency-committee-on-novel-coronavirus-(2019-ncov)
  20. Centers for Disease Control & Prevention (CDC) CDC Confirms Person-to-Person Spread of New Coronavirus in the United States. Press Release. Jan 30, 2020 https://www.cdc.gov/media/releases/2020/p0130-coronavirus-spread.html - Rothe C, Schunk M, Sothmann P, Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany. N Engl J Med, Jan 30, 2020 PMID: 32003551 https://www.nejm.org/doi/full/10.1056/NEJMc2001468
  21. Brunk D HHS Declares Coronavirus Emergency,Orders Quarantine - Medscape - Jan 31, 2020. https://www.medscape.com/viewarticle/924640 - Walker M U.S. Declares Public Health Emergency for Coronavirus Dramatic steps taken for quarantining travelers, based on "unknown" nature of virus. MedPage Today. Jan 31, 2020 https://www.medpagetoday.com/infectiousdisease/publichealth/84662
  22. Young J, George S, Kottasova I Nearly 12,000 cases of the coronavirus worldwide. CNN. Feb 1, 20220 https://www.cnn.com/asia/live-news/coronavirus-outbreak-02-01-20-intl-hnk/index.html
  23. Hollingsworth J Coronavirus. CNN. Feb 2, 2020 https://www.cnn.com/2020/02/02/asia/wuhan-coronavirus-philippines-intl-hnk/index.html
  24. Center for Disease Control & Prevention (CDC) Update and Interim Guidance on Outbreak of 2019 Novel Coronavirus (2019-nCoV). CDC Health Update. February 1, 2020 https://emergency.cdc.gov/han/han00427.asp
  25. Holshue ML, DeBolt C, Lindquist S et al First Case of 2019 Novel Coronavirus in the United States. N Emgl J Med. Jam 31, 2020 PMID: 32004427 https://www.nejm.org/doi/full/10.1056/NEJMoa2001191
  26. Center for Disease Control & Prevention (CDC) CDC Confirms Seventh Case of 2019 Novel Coronavirus Media Statement. Jan 31. 2020 https://www.cdc.gov/media/releases/2020/s0131-seventh-case-coronavirus.html
  27. Wu JT, Leung K, Leung GM Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study. Lancet. Jan 31, 2020 PMID: 32014114 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30260-9/fulltext
  28. Center for Disease Control & Prevention (CDC) 2019 Novel Coronavirus (2019-nCoV) in the U.S. Situation Simmary. Feb 3, 2020 https://www.cdc.gov/coronavirus/2019-ncov/cases-in-us.html
  29. National Health Commission of the People's Republic of China Feb 3 2020: Daily briefing on novel coronavirus cases in China http://en.nhc.gov.cn/2020-02/03/c_76111.htm - Feb 4 2020: Daily briefing on novel coronavirus cases in China http://en.nhc.gov.cn/2020-02/04/c_76131.htm - Feb 5 2020: Daily briefing on novel coronavirus cases in China http://en.nhc.gov.cn/2020-02/05/c_76219.htm - Feb 11: Daily briefing on novel coronavirus cases in China http://en.nhc.gov.cn/2020-02/11/c_76429.htm - Feb 12: Daily briefing on novel coronavirus cases in China http://en.nhc.gov.cn/2020-02/12/c_76463.htm - Feb 13: Daily briefing on novel coronavirus cases in China http://en.nhc.gov.cn/2020-02/13/c_76512.htm - Feb 18: Daily briefing on novel coronavirus cases in China http://en.nhc.gov.cn/2020-02/18/c_76645.htm - Feb 20: Daily briefing on novel coronavirus cases in China http://en.nhc.gov.cn/2020-02/20/c_76730.htm - National Health Commission of the People's Republic of China http://en.nhc.gov.cn/index.html
  30. Center for Disease Control & Prevention (CDC) 2019 Novel Coronavirus, Wuhan, China. https://www.cdc.gov/coronavirus/2019-ncov/index.html - Interim US Guidance for Risk Assessment and Public Health Management of Persons with Potential 2019 Novel Coronavirus (2019-nCoV.) Exposure in Travel-associated or Community Settings. https://www.cdc.gov/coronavirus/2019-ncov/php/risk-assessment.html
  31. del Rio C, Melani PN 2019 Novel Coronavirus - Important Information for Clinicians JAMA. Published online February 5, 2020 PMID: 32022836 https://jamanetwork.com/journals/jama/fullarticle/2760782
  32. Twachtman G 12th Coronavirus Case Confirmed in Wisconsin Medscape - Feb 05, 2020. https://www.medscape.com/viewarticle/924857 - Wisconsin Department of Health Services, Feb 5, 2020 2019 Novel Coronavirus Case is Confirmed in Wisconsin. Risk to Wisconsin Public Remains Low. https://www.dhs.wisconsin.gov/news/releases/020520.htm
  33. FDA Press Announcement Feb 4, 2020 FDA Takes Significant Step in Coronavirus Response Efforts, Issues Emergency Use Authorization for the First 2019 Novel Coronavirus Diagnostic. Critical Milestone Reached in Response to this Outbreak. https://www.fda.gov/news-events/press-announcements/fda-takes-significant-step-coronavirus-response-efforts-issues-emergency-use-authorization-first
  34. Brink D Remdesivir Under Study as Treatment for Novel Coronavirus. Medscape - Feb 07, 2020. https://www.medscape.com/viewarticle/924964
  35. Walker M Track the Coronavirus Outbreak on Johns Hopkins Live Dashboard. - Realtime infection and death data from five sources. MedPage Today. February 04, 2020 https://www.medpagetoday.com/infectiousdisease/publichealth/84698 - Johns Hopkins Live Dashboard. https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6
  36. Wang D, Hu B, Hu C et al Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus - Infected Pneumonia in Wuhan, China. JAMA. Published online Feb 7, 2020 PMID: 32031570 https://jamanetwork.com/journals/jama/fullarticle/2761044
  37. Gorbalenya AE Severe acute respiratory syndrome-related coronavirus - The species and its viruses, a statement of the Coronavirus Study Group. biorxiv. Cold Spring Harbor Laboratory, Feb 11, 2029 https://www.biorxiv.org/content/10.1101/2020.02.07.937862v1 - Centers for Disease Control & Prevention (CDC) CDC Confirms 13th Case of 2019 Novel Coronavirus Media Statement. February 10, 2020 https://www.cdc.gov/media/releases/2020/s0210-coronavirus-new-us-case.html - World Health Organization (WHO) WHO Director-General's remarks at the media briefing on 2019-nCoV on 11 February 2020. https://www.who.int/dg/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020 - UC San Diego Health. Feb 11, 2019 Coronavirus (COVID-19) Updates https://health.ucsd.edu/news/Pages/Coronavirus-update.aspx
  38. Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W et al Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. Feb 12, 2020 PMID: 32151335 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30360-3/fulltext
  39. World Health Organization (WHO) Coronavirus disease 2019 (COVID-19)Situation Report - 28. Feb 17, 2020 https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200217-sitrep-28-covid-19.pdf
  40. WHO Director-General's remarks at the media briefing on COVID-19 outbreak on 18 February 2020. https://www.who.int/dg/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-covid-19-outbreak-on-18-february-2020
  41. Xu XW, Wu XX, Jiang XG et al Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series PMID: 32075786 Free Article https://www.bmj.com/content/368/bmj.m606
  42. Gilbert M, Pullano G, Pinotti F et al Preparedness and vulnerability of African countries against importations of COVID-19: a modelling study. Lancet. Feb 2020 PMID: 32087820 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30411-6/fulltext
  43. Centers for Disease Control & Prevention (CDC) Coronavirus Disease 2019 (COVID-19) in the U.S. Updated Feb 24, 2020 https://www.cdc.gov/coronavirus/2019-ncov/cases-in-us.html
  44. Young K, Fairchild DG, Di Francesco L CDC Anticipates Community Spread of COVID-19 in U.S. Physician's First Watch, Feb 26, 2020 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org
  45. Livingston E, Bucher K, Rekito A. JAMA Infographic: Coronavirus Disease 2019 and Influenza. JAMA. Published online February 26, 2020 PMID: 32101254 https://jamanetwork.com/journals/jama/fullarticle/2762386
  46. Centers for Disease Control & Prevention (CDC) Interim Guidance for Public Health Personnel Evaluating Persons Under Investigation (PUIs) and Asymptomatic Close Contacts of Confirmed Cases at Their Home or Non-Home Residential Settings. https://www.cdc.gov/coronavirus/2019-ncov/php/guidance-evaluating-pui.html
  47. AMA Morning News. Dec 23, 2020 American Medical Association
  48. Orciari Herman A, Sadoughi S, Saitz R COVID-19: CDC Reports First Possible Case of Community Spread in U.S. CDC Anticipates Community Spread of COVID-19 in U.S. Physician's First Watch, Feb 26, 2020 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org
  49. del Rio C, Malani PN COVID-19 - New Insights on a Rapidly Changing Epidemic. JAMA. Published online February 28, 2020 PMID: 32108857 https://jamanetwork.com/journals/jama/fullarticle/2762510
  50. Gever J Looks Like Coronavirus Community Spread Is Here - Three new COVID-19 cases with unknown origin, CDC reports. MedPage Today. February 29, 2020 https://www.medpagetoday.com/infectiousdisease/covid19/85161
  51. Person in Washington state first in US to die from new virus Associated Press. Feb 29, 2020 (via MSN Breaking News) https://www.msn.com/en-us/news/us/person-in-washington-state-first-in-us-to-die-from-new-virus/ar-BB10zcXA - Maxouris C, Andone D First death from coronavirus in the United States has occurred in Washington state, officials say. CNN Breaking News. Sat February 29, 2020 https://www.cnn.com/2020/02/29/health/us-coronavirus-saturday/index.html - Schneider ME S Reports First Death From COVID-19, in Washington State. Medscape - Feb 29, 2020. https://www.medscape.com/viewarticle/925932 - Centers for Disease Control & Prevention (CDC) CDC, Washington State Report First COVID-19 Death Media Statement. February 29, 2020 https://www.cdc.gov/media/releases/2020/s0229-COVID-19-first-death.html
  52. Beasley D How long can coronavirus survive on surfaces? Reuters via MSN Feb 28. 2020 https://www.msn.com/en-us/health/wellness/how-long-can-coronavirus-survive-on-surfaces/ar-BB10xkvI
  53. Walker M FAQs About COVID-19 - Answers to frequently asked questions based on the latest medical research and public health data. MedPage Today. February 29, 2020 https://www.medpagetoday.com/infectiousdisease/covid19/85165 - van Doremalen N, Bushmaker T, Morris DH et al Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1. N Engl J Med. March 17, 2020 PMID: 32182409 https://www.nejm.org/doi/full/10.1056/NEJMc2004973
  54. Orciari Herman A, Fairchild DG, Hefner E COVID-19: CDC Reports First Possible Case of Community Spread in U.S. CDC Anticipates Community Spread of COVID-19 in U.S. Physician's First Watch, March 2, 2020 - Young K, Fairchild DG, Di Francesco L COVID-19: Secondary Attack Rate / Equivocal Lopinavir-Ritonavir Results Physician's First Watch, March 3, 2020 David G. Fairchild DG, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org
  55. Burke RM, Midgley CM, Dratch A, et al. Active Monitoring of Persons Exposed to Patients with Confirmed COVID-19 - United States, January-February 2020. MMWR Morb Mortal Wkly Rep. ePub: 3 March 2020. PMID: 32134909 https://www.cdc.gov/mmwr/volumes/69/wr/mm6909e1.htm
  56. Young BE, Ong SWX, Kalimuddin S et al Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore. JAMA. Published online March 3, 2020. PMID: 32125362 https://jamanetwork.com/journals/jama/fullarticle/2762688
  57. Walker M COVID-19 Update: First Calif. Death; Another Cruise Ship? MedPage Today March 5, 2020 https://www.medpagetoday.com/infectiousdisease/covid19/85245
  58. Frellick M COVID-19 Mortality Rate May Be 'Considerably Less Than 1%' Medscape - Mar 02, 2020 https://www.medscape.com/viewarticle/926089 - Fauci AS, Lane HC, Redfield RR Covid-19 - Navigating the Uncharted. N Emgl J Med. Feb 28, 2020 PMID: 32109011 https://www.nejm.org/doi/full/10.1056/NEJMe2002387
  59. Hoffmann M, Kleine-Weber H, Schroeder S SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020 Mar 4. pii: S0092-8674(20)30229-4. PMID: 32142651
  60. Goodman B. The Power of Hand-Washing to Prevent Coronavirus. Medscape - Mar 06, 2020. https://www.medscape.com/viewarticle/926373
  61. Wu Z, McGoogan JM Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China. Summary of a Report of 72,314 Cases From the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239-1242. Feb 24 PMID: 32091533 https://jamanetwork.com/journals/jama/fullarticle/2762130
  62. Wang Q, Berger NA, Xu R Analyses of Risk, Racial Disparity, and Outcomes Among US Patients With Cancer and COVID-19 Infection. JAMA Oncol. 2020. Dec 10;e206178. PMID: 33300956 PMCID: PMC7729584 https://jamanetwork.com/journals/jamaoncology/fullarticle/2773500#
  63. van der Made CI, Simons A, Schuurs-Hoeijmakers J et al Presence of Genetic Variants Among Young Men With Severe COVID-19. JAMA. Published online July 24, 2020 PMID: 32706371 https://jamanetwork.com/journals/jama/fullarticle/2768926 - Plenge RM Molecular Underpinnings of Severe Coronavirus Disease 2019. JAMA. Published online July 24, 2020 PMID: 32706364 https://jamanetwork.com/journals/jama/fullarticle/2768925
  64. Lauer SA, Grantz KH, Bi Q The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application. Ann Intern Med. 2020. March 10. PMID: 32150748 https://annals.org/aim/fullarticle/2762808/incubation-period-coronavirus-disease-2019-covid-19-from-publicly-reported
  65. Zhou F, Yu T, Du R et al Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet March 9,2020 PMID: 32171076 https://www.thelancet.com/pb-assets/Lancet/pdfs/S014067362305663.pdf
  66. Orciari Herman A COVID-19 Can Look Like the Common Cold, Researchers Say. NEJM Journal Watch. March 10, 2020 Massachusetts Medical Society (subscription needed) http://www.jwatch.org
  67. Reuters Staff Obstructive Sleep Apnea Linked With Worse COVID-19 Medscape - Oct 08, 2020. https://www.medscape.com/viewarticle/938814?
  68. Murthy S, Gomersall CD, Fowler RA. Care for Critically Ill Patients With COVID-19. JAMA. Published online March 11, 2020 PMID: 32159735 https://jamanetwork.com/journals/jama/fullarticle/2762996
  69. Orciari Herman A, Sadoughi S, Saitz R WHO Declares COVID-19 a Pandemic Physician's First Watch, March 11, 2020 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org - World Health Organization (WHO) WHO News Briefing March 11, 2020 https://twitter.com/WHO/status/1237774421307228160 Critical preparedness, readiness and response actions for COVID-19 https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/critical-preparedness-readiness-and-response-actions-for-covid-19
  70. Hollander JE, Carr BG Perspective: Virtually Perfect? Telemedicine for Covid-19 N Eng L Med. March 11, 2020 PMID: 32160451 https://www.nejm.org/doi/full/10.1056/NEJMp2003539
  71. Wang M, Cao R, Zhang L et al Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271. PMID: 32020029 Free PMC Article
  72. Kampf G, Todt D, Pfaender S, Steinmann E. Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents J Hosp Infect. 2020 Mar;104(3):246-251. Review. PMID: 32035997
  73. World Health Organization (WHO) Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected. Interim Guidance. March 13, 2020 https://www.who.int/publications-detail/clinical-management-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected
  74. Wu C, Chen X, Cai Y et al Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China. JAMA Intern Med. Published online March 13, 2020. PMID: 32167524 https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2763184
  75. FDA News Release. March 13, 2020 Coronavirus (COVID-19) Update: FDA Issues Emergency Use Authorization to Thermo Fisher. https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-issues-emergency-use-authorization-thermo-fisher
  76. Parodi SM, Liu VX. From Containment to Mitigation of COVID-19 in the US. JAMA. Published online March 13, 2020 PMID: 32167525 https://jamanetwork.com/journals/jama/fullarticle/2763187
  77. Li R, Pei S, Chen B et al Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV2). Science 16 Mar 2020: PMID: 32179701 https://science.sciencemag.org/content/early/2020/03/13/science.abb3221
  78. Ng K, Poon BH, Puar THK et al COVID-19 and the Risk to Health Care Workers: A Case Report. Ann Intern Med. 2020. March 16 PMID: 32176257 https://annals.org/aim/fullarticle/2763329/covid-19-risk-health-care-workers-case-report
  79. Statement from the American Heart Association, the Heart Failure Society of America and the American College of Cardiology. Patients taking ACE-i and ARBs who contract COVID-19 should continue treatment, unless otherwise advised by their physician. News Release. March 17, 2020 https://newsroom.heart.org/news/patients-taking-ace-i-and-arbs-who-contract-covid-19-should-continue-treatment-unless-otherwise-advised-by-their-physician - HFSA/ACC/AHA Statement Addresses Concerns Re: Using RAAS Antagonists in COVID-19. Am Coll Cardiol. March 17, 2020 https://www.acc.org/latest-in-cardiology/articles/2020/03/17/08/59/hfsa-acc-aha-statement-addresses-concerns-re-using-raas-antagonists-in-covid-19 - Famg L, Karakiulakis G, Roth M. Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Lancet Respir Med 2020. March 11. PMID: 32171062 https://www.thelancet.com/action/showPdf - Vaduganathan M, Vardeny O, Michel T et al Renin-Angiotensin-Aldosterone System Inhibitors in Patients with Covid-19. N Engl J Med. March 30, 2020 PMID: 32227760 https://www.nejm.org/doi/full/10.1056/NEJMsr2005760 - Patel AB, Verma A. COVID-19 and angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: What is the evidence? JAMA 2020 Mar 24; PMID: 32208485 https://jamanetwork.com/journals/jama/fullarticle/2763803 - Gurwitz D. Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics. Drug Dev Res 2020 Mar 4 PMID: 32129518 https://onlinelibrary.wiley.com/doi/full/10.1002/ddr.21656 - Muller BS et al. Regret among primary care physicians: A survey of diagnostic decisions. BMC Fam Pract 2020 Mar 17; 21:53 PMID: 32183738 Free PMC Article https://bmcfampract.biomedcentral.com/articles/10.1186/s12875-020-01125-w - Zhang P, Zhu L, Cai J et al Association of Inpatient Use of Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers with Mortality Among Patients With Hypertension Hospitalized With COVID-19. Circ Res. April 17, 2020 PMID: 32302265 https://www.ahajournals.org/doi/abs/10.1161/CIRCRESAHA.120.317134 - Li J, Wang X, Chen J et al Association of Renin-Angiotensin System Inhibitors With Severity or Risk of Death in Patients With Hypertension Hospitalized for Coronavirus Disease 2019 (COVID-19) Infection in Wuhan, China. JAMA Cardiol. Published online April 23, 2020 PMID: 32324209 https://jamanetwork.com/journals/jamacardiology/fullarticle/2765049 - Mancia G, Rea F, Ludergnani M, Apolone G, Corrao G Renin-Angiotensin-Aldosterone System Blockers and the Risk of Covid-19. N Engl J Med. May 1, 2020 PMID: 32356627 https://www.nejm.org/doi/full/10.1056/NEJMoa2006923 - Reynolds HR, Adhikari S, Pulgarin C et al Renin-Angiotensin-Aldosterone System Blockers and Risk of Covid-19. N Engl J Med. May 1, 2020 PMID: 32356628 https://www.nejm.org/doi/full/10.1056/NEJMoa2008975 - Jarcho JA, Ingelfinger JR, Hamel MB et al Inhibitors of the Renin-Angiotensin-Aldosterone System and COVID-19. N Engl J Med. May 1, 2020 PMID: 32356625 https://www.nejm.org/doi/full/10.1056/NEJMe2012924?query=RP - de Abajo FJ et al. Use of renin-angiotensin-aldosterone system inhibitors and risk of COVID-19 requiring admission to hospital: A case-population study. Lancet. 2020 May 14:S0140-6736(20)31030-8. PMID: 32416785 https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(20)31030-8.pdf - Fosbol EL, Butt JM, Ostergaard L et al Association of Angiotensin-Converting Enzyme Inhibitor or Angiotensin Receptor Blocker Use With COVID-19 Diagnosis and Mortality. JAMA. Published online June 19, 2020. PMID: 32558877 https://jamanetwork.com/journals/jama/fullarticle/2767669 - Curfman G Renin-Angiotensin-Aldosterone Inhibitors and Susceptibility to and Severity of COVID-19. JAMA. Published online June 19, 2020. PMID: 32558905 https://jamanetwork.com/journals/jama/fullarticle/2767668
  80. Lauer SA, Grantz KH, Bi Q et al The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application. Ann Intern Med. 2020. March 10 PMID: 32150748 https://annals.org/aim/fullarticle/2762808/incubation-period-coronavirus-disease-2019-covid-19-from-publicly-reported
  81. Yao X,Ye F Zhang M et al In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clinical Infectious Diseases. March 2020 https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciaa237/5801998 - Lecrubier A COVID-19: Could Hydroxychloroquine Really Be the Answer? Medscape. March 18, 2020 https://www.medscape.com/viewarticle/927033 - Chen Z, Hu J, Zhang Z et al Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial. Unreviewed manuscript. April 1, 2020 https://www.medrxiv.org/content/10.1101/2020.03.22.20040758v2.full.pdf
  82. Cao B, Wang Y, Wen D et al A Trial of Lopinavir - Ritonavir in Adults Hospitalized with Severe Covid-19. N Engl J Med. March 18, 2020 PMID: 32187464 Free PMC article https://www.nejm.org/doi/full/10.1056/NEJMoa2001282
  83. Reuters Staff Online Tool Estimates COVID-19 Mortality Risk Medscape - Dec 25, 2020. https://bit.ly/2LhYsmf https://www.medscape.com/viewarticle/943226 - Jin J, Agarwala N, Kundu P et al Individual and community-level risk for COVID-19 mortality in the United States. Nat Med (2020) Dec 11 PMID: 33311702 https://bit.ly/2LhYsmf
  84. Bruer W, Simko-Bednarski E, Azad A, Hilk M In strategic shift, doctors in America's two largest cities are told to skip some coronavirus testing. CNN. March 21, 2020 https://www.cnn.com/world/live-news/coronavirus-outbreak-03-21-20-intl-hnk/h_78c431662464112a27434663a0860cdc
  85. IDSA. March 17, 2020 COVID-19 Prioritization of Diagnostic Testing https://www.idsociety.org/globalassets/idsa/public-health/covid-19-prioritization-of-dx-testing.pdf
  86. FDA Safety Alert. March 19, 2020 FDA advises patients on use of non-steroidal anti-inflammatory drugs (NSAIDs) for COVID-19 https://www.fda.gov/drugs/drug-safety-and-availability/fda-advises-patients-use-non-steroidal-anti-inflammatory-drugs-nsaids-covid-19
  87. FDA Letter to Health Care Providers. March 2020 Medical Glove Conservation Strategies: Letter to Health Care Providers https://www.fda.gov/medical-devices/letters-health-care-providers/medical-glove-conservation-strategies-letter-health-care-providers
  88. FDA Letter to Health Care Providers. March 2020 Ventilator Supply Mitigation Strategies: Letter to Health Care Providers. https://www.fda.gov/medical-devices/letters-health-care-providers/ventilator-supply-mitigation-strategies-letter-health-care-providers
  89. Arentz M, Yim E, Klaff L et al Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State. JAMA. Published online March 19, 2020. PMID: 32191259 https://jamanetwork.com/journals/jama/fullarticle/2763485
  90. Moriarty LF, Plucinski MM, Marston BJ et al. Public Health Responses to COVID-19 Outbreaks on Cruise Ships - Worldwide, February-March 2020. MMWR Morb Mortal Wkly Rep. 2020 Mar 27;69(12):347-352. PMID: 32214086 https://www.cdc.gov/mmwr/
  91. Hopkins C, Kumar N Loss of sense of smell as marker of COVID-19 infection. ENT UK. March 2020 https://www.entuk.org/sites/default/files/files/Loss%20of%20sense%20of%20smell%20as%20marker%20of%20COVID.pdf - NEJM JWatch Editors The Latest in COVID-19 News: Week Ending March 28 Physician's First Watch, March 28, 2020 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org - Spinato G, Fabbris C, Polesel J et al Alterations in Smell or Taste in Mildly Symptomatic Outpatients With SARS-CoV-2 Infection. JAMA. Published online April 22, 2020 PMID: 32320008 https://jamanetwork.com/journals/jama/fullarticle/2765183 - Carroll L COVID-19 Associated Loss of Smell, Taste Mostly Resolves Within Weeks Medscape - Jul 02, 2020.. https://www.medscape.com/viewarticle/933347 - Boscolo-Rizzo P, Borsetto D, Fabbris C et al Evolution of Altered Sense of Smell or Taste in Patients With Mildly Symptomatic COVID-19. JAMA Otolaryngol Head Neck Surg. Published online July 2, 2020 PMID: 32614442 https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2767781 - Levy JM Treatment Recommendations for Persistent Smell and Taste Dysfunction Following COVID-19 - The Coming Deluge. JAMA Otolaryngol Head Neck Surg. Published online July 2, 2020 PMID: 32614399 https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2767779
  92. Kincaid E COVID-19 Daily: Lung Ultrasound Triage, Telemedicine Tips - Medscape - Mar 24, 2020. https://www.medscape.com/viewarticle/927472
  93. JAMA Morning Rounds. March 25, 2020 FDA to allow physicians to use plasma donated by coronavirus survivors to treat critically ill patients. - NBC News. March 24, 2020 FDA will allow doctors to treat critically ill coronavirus patients with blood from survivors https://www.n bcnews.com/news/us-news/fda-will-allow-doctors-treat-critically-ill-coronavirus-patients-blood-n1167831
  94. Pan C, Chen L, Lu C et al Lung Recruitability in SARS-CoV-2 Associated Acute Respiratory Distress Syndrome: A Single-center, Observational Study. Am J Respir Crit Care Med. 2020 Mar 23. PMID: 32200645 https://www.atsjournals.org/doi/pdf/10.1164/rccm.202003-0527LE
  95. Gautret P, Lagier JC, Parola P Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int J Antimicrob Agents. 2020 Mar 20:105949. PMID: 32205204 https://drive.google.com/file/d/186Bel9RqfsmEx55FDum4xY_IlWSHnGbj/view
  96. Shi S, Qin M, Shen B et al Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China. JAMA Cardiol. Published online March 25, 2020 PMID: 32211816 https://jamanetwork.com/journals/jamacardiology/fullarticle/2763524 - Yang C, Jin Z An Acute Respiratory Infection Runs Into the Most Common Noncommunicable Epidemic - COVID-19 and Cardiovascular Diseases. JAMA Cardiol. Published online March 25, 2020 PMID: 32211809 https://jamanetwork.com/journals/jamacardiology/fullarticle/2763525
  97. Song F, Shi N, Shan F et al. Emerging 2019 novel coronavirus (2019-nCoV) pneumonia. Radiology 2020 Apr; 295:210 PMID: 32027573 https://pubs.rsna.org/doi/10.1148/radiol.2020200274
  98. Lam TT. Shum MH, Zhu HC et al. Identifying SARS-CoV-2 related coronaviruses in Malayan pangolins. Nature. March 26, 2020 PMID: 32218527 https://www.nature.com/articles/s41586-020-2169-0_reference.pdf - Kuznia R, Griffin D How did coronavirus break out? Theories abound as researchers race to solve genetic detective story. CNN. Mon April 6, 2020 https://www.cnn.com/2020/04/06/us/coronavirus-scientists-debate-origin-theories-invs/index.html
  99. Blasco A, Coronado MJ, Hernandez-Terciado F et al Assessment of Neutrophil Extracellular Traps in Coronary Thrombus of a Case Series of Patients With COVID-19 and Myocardial Infarction. JAMA Cardiol. Published online December 29, 2020 PMID: 33372956 https://jamanetwork.com/journals/jamacardiology/fullarticle/2774536
  100. Shen C, Wang Z, Zhao F et al Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma JAMA. 2020;323(16):1582-1589. PMID: 32219428 https://jamanetwork.com/journals/jama/fullarticle/2763983 - Roback JD, Guarner J. Convalescent Plasma to Treat COVID-19. Possibilities and Challenges. JAMA. Published online March 27, 2020 PMID: 32219429 https://jamanetwork.com/journals/jama/fullarticle/2763982 - FDA - Investigational New Drug (IND). March 24, 2020 Investigational COVID-19 Convalescent Plasma - Emergency INDs https://www.fda.gov/vaccines-blood-biologics/investigational-new-drug-ind-or-device-exemption-ide-process-cber/investigational-covid-19-convalescent-plasma-emergency-inds - FDA News Release Coronavirus (COVID-19) Update: Daily Roundup April 3, 2020 https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-daily-roundup-april-3-2020 - Duab K, Liu B, Li C et al Effectiveness of convalescent plasma therapy in severe COVID-19 patients. PNAS first published April 6, 2020 PMID: 32253318 https://www.pnas.org/content/early/2020/04/02/2004168117 - U.S. Department of Health and Human Services. Food and Drug Administration. Center for Biologics Evaluation and Research. April 2020 Investigational COVID-19 Convalescent Plasma Guidance for Industry. https://www.fda.gov/media/136798/download - Duan K, Liu B, Li C et al. Effectiveness of convalescent plasma therapy in severe COVID-19 patients. Proc Natl Acad Sci U S A 2020 Apr 6; PMID: 32253318 https://www.pnas.org/content/early/2020/04/02/2004168117 - FDA Statement. April 16, 2020 Coronavirus (COVID-19) Update: FDA Encourages Recovered Patients to Donate Plasma for Development of Blood-Related Therapies. https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-encourages-recovered-patients-donate-plasma-development-blood
  101. Remaly J COVID-19 Update: Antibodies Decrease,UV Light Fights Virus Medscape - Jul 23, 2020. https://www.medscape.com/viewarticle/934501
  102. Stone W Using UV Light to Fight COVID-19 Spread Medscape - Jul 23, 2020. https://www.medscape.com/viewarticle/934446103) Kimball A, Hatfield KM, Arons M, et al. Asymptomatic and Presymptomatic SARS-CoV-2 Infections in Residents of a Long-Term Care Skilled Nursing Facility - King County, Washington, March 2020. MMWR Morb Mortal Wkly Rep. ePub: 27 March 2020. PMID: 32240128 https://www.cdc.gov/mmwr/volumes/69/wr/mm6913e1.htm
  103. Achenbach J, Guarino B, Sun LH, Stanley-Becker I First case of highly infectious coronavirus variant detected in Colorado. Washington Post. Dec 29, 2020 https://www.msn.com/en-us/health/medical/first-case-of-highly-infectious-coronavirus-variant-detected-in-colorado/ar-BB1cktU6 - Walker M Just How Much More Transmissible Is the New Coronavirus Variant? MedPage Today January 2, 2021 https://www.medpagetoday.com/infectiousdisease/covid19/90499 - Volz E, Mishra S, Chand M et al Report 42 - Transmission of SARS-CoV-2 Lineage B.1.1.7 in England: insights from linking epidemiological and genetic data. MRC Centre for Global Infectious Disease Analysis. Dec 31, 2020 https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/covid-19/report-42-sars-cov-2-variant/
  104. Escobar LE, Molina-Cruz A, Barillas-Mury C BCG vaccine protection from severe coronavirus disease 2019 (COVID-19). Proc Natl Acad Sci U S A. 2020 Jul 9:2020 PMID: 32647056 https://www.pnas.org/content/early/2020/07/07/2008410117
  105. Nair G, Li W, Maric D et al Microvascular Injury in the Brains of Patients with Covid-19. N Engl J Med. Dec 30, 2020 PMID: 33378608 https://www.nejm.org/doi/full/10.1056/NEJMc2033369
  106. McCulloch DJ, Kim AE, Wilcox NC et al Comparison of Unsupervised Home Self-collected Midnasal Swabs With Clinician-Collected Nasopharyngeal Swabs for Detection of SARS-CoV-2 Infection. JAMA Netw Open. 2020;3(7):e2016382. PMID: 32697321 Free article https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2768535
  107. Kincaid E COVID-19 Daily: Universal Mask Usage, Death Projection. Medscape - Apr 01, 2020. https://www.medscape.com/viewarticle/927974 - Firth S It's Official: CDC Recommends Public Wear Face Masks - Stresses use of cloth coverings, not medical grade, for ordinary people. https://www.medpagetoday.com/infectiousdisease/covid19/85800 - Centers for Disease Control & Prevention (CDC) Recommendation Regarding the Use of Cloth Face Coverings, Especially in Areas of Significant Community-Based Transmission. https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/cloth-face-cover.html - Centers for Disease Control & Prevention (CDC) Use of Cloth Face Coverings to Help Slow the Spread of COVID-19 https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/diy-cloth-face-coverings.html - Greenhalgh T, Schmid MB, Czypionka T et al Face masks for the public during the covid-19 crisis BMJ 2020;369:m1435 PMID: 32273267 https://www.bmj.com/content/369/bmj.m1435
  108. Klompas M, Morris CA, Sinclair J et al Universal Masking in Hospitals in the Covid-19 Era. N Engl J Med. April 1, 2020 PMID: 32237672 https://www.nejm.org/doi/full/10.1056/NEJMp2006372
  109. Panagiotou OA, Kosar CM, White EM et al Risk Factors Associated With All-Cause 30-Day Mortality in Nursing Home Residents With COVID-19. JAMA Intern Med. Published online January 4, 2021. PMID: 33394006 https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2774729
  110. Xie Y, Bowe B, Maddukuri G et al. Comparative evaluation of clinical manifestations and risk of death in patients admitted to hospital with covid-19 and seasonal influenza: Cohort study. BMJ 2020 Dec 15; 371:m4677 PMID: 33323357 PMCID: PMC7735416 Free PMC article https://www.bmj.com/content/371/bmj.m4677
  111. George J Long-Term Neurologic Symptoms Emerge in COVID-19 - Hospitalized patients show deficits including cognitive impairment 6 months later MedPage Today January 7, 2021 https://www.medpagetoday.com/infectiousdisease/covid19/90587 - Pilotto A, Cristillo V, Piccinelli SC et al COVID-19 severity impacts on long-term neurological manifestation after hospitalisation. medRxiv. 2021. Jan 2 https://www.medrxiv.org/content/10.1101/2020.12.27.20248903v1
  112. Chen T, Wu D, Chen H et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: Retrospective study. BMJ 2020 Mar 26; 368:m1091. PMID: 32217556 Free Article https://www.bmj.com/content/368/bmj.m1091
  113. Walker M Most Hospitalized COVID Patients Not Fully Recovered 6 Months Post- Discharge - Fatigue, weakness are most common, Chinese study finds. MedPage Today January 8, 2021 https://www.medpagetoday.com/infectiousdisease/covid19/90618 - Huang C, Huang L, Wang Y et al 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet. 2021. Jan 8 PMID: 33428867 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)32656-8/fulltext - paper under investigation for data errors Buzzy Lancet long COVID paper under investigation for 'data errors' https://retractionwatch.com/2022/12/01/buzzy-lancet-long-covid-paper-under-investigation-for-data-errors/
  114. Pud BT, Badenes R, La Calle GH et al Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study. Lancet Respiratory Medicine. 2021. Jan 8 PMID: 33428871 https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30552-X/fulltext
  115. Zhou H, Lu S, Chen J et al. The landscape of cognitive function in recovered COVID-19 patients. J Psychiatr Res 2020 Oct; 129:98. PMID: 32912598 https://www.sciencedirect.com/science/article/pii/S0022395620308542
  116. Fiore K COVID Clinical Observations: Intubating Colleagues, Proning to Prevent the Vent - Physicians share clinical information on Twitter to help others prepare for when the COVID wave hits their hospitals. MedPage Today. April 2, 2020 https://www.medpagetoday.com/infectiousdisease/covid19/85767
  117. Brooks M First Presumptive Case of Encephalitis Linked to COVID-19 Reported. Medscape - Apr 03, 2020. https://www.medscape.com/viewarticle/928069
  118. AHA/ASA Stroke Council Leadership Temporary Emergency Guidance to US Stroke Centers During the COVID-19 Pandemic. Stroke. April 1, 2020 PMID: 32233972 https://www.ahajournals.org/doi/10.1161/STROKEAHA.120.030023
  119. Bilaloglu S, Aphinyanaphongs V, Jones S et al Thrombosis in Hospitalized Patients With COVID-19 in a New York City Health System. JAMA. Published online July 20, 2020 PMID: 32702090 https://jamanetwork.com/journals/jama/fullarticle/2768715
  120. Young K, Sofair A, Chavey WE COVID-19: Early Vaccine Results / Blood Donation Changes / Environmental Contamination Physician's First Watch, April 2, 2020 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org
  121. Kim E, Erdosb G, Huang S et al Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational development. EBioMedicine. April 1, 2020 PMID: 32249203 Free PMC Article https://www.thelancet.com/pdfs/journals/ebiom/PIIS2352-3964(20)30118-3.pdf
  122. Vernimmen T Closing In on the New Coronavirus Medscape - Apr 03, 2020. https://www.medscape.com/viewarticle/928113 - Wrapp D, Wang N, Corbett KS et al Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science 13 Mar 2020: Vol. 367, Issue 6483, pp. 1260-1263 PMID: 32075877 https://science.sciencemag.org/content/367/6483/1260
  123. Yeoh YK, Zuo T, Lui GCY et al Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19. Gut. 2021. Jan 11, PMID: 33431578 https://gut.bmj.com/content/early/2021/01/04/gutjnl-2020-323020.info
  124. Edlow AG, Li JZ, Collier AY et al. Assessment of maternal and neonatal SARS-CoV-2 viral load, transplacental antibody transfer, and placental pathology in pregnancies during the COVID-19 pandemic. JAMA Netw Open 2020 Dec 22; 3:e2030455. PMID: 33351086 PMCID: PMC7756241 Free PMC article https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2774428
  125. Maa J Why Covid-19 might make you rethink your smoking habits. CNN Opinion. April 6, 2020 https://www.cnn.com/2020/04/06/opinions/smoking-vaping-covid-19-coronavirus-maa/index.html - Patanavanich R, Glantz SA Smoking is Associated with COVID-19 Progression: A Meta-Analysis. medRxiv preprint. Not peer-reviewed from UCSF https://www.medrxiv.org/content/10.1101/2020.04.13.20063669v1.full.pdf
  126. Lei S, Jiang F, Su W et al Clinical characteristics and outcomes of patients undergoing surgeries Eduring the incubation period of COVID-19 infection. EClinicalmedicine. Published by Lancet. April 4, 2020 PMID: 32292899 Free PMC Article https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(20)30075-4/fulltext - COVIDSurg Collaborative Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study. Lancet. May 29, 2020 PMID: 32479829 Free PMC article https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31182-X/fulltext
    1. urukawa Y, Kansaku R Amabie - A Japanese Symbol of the COVID-19 Pandemic. JAMA. Published online July 17, 2020. The Arts and Medicine PMID: 32678430 https://jamanetwork.com/journals/jama/fullarticle/2768645
  128. Zhang Y, Xiao M, Zhang S et al Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19. N Engl J Med. April 8, 2020 PMID: 32268022 https://www.nejm.org/doi/full/10.1056/NEJMc2007575
  129. Boyles S Smokers Face Greater Risk From COVID-19 - Health experts say now is the time to quit MedPage Today. April 8, 2020 https://www.medpagetoday.com/infectiousdisease/covid19/85862 - Guan W, Ni Z, Hu Y et al Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. Feb 28, 2020 PMID: 32109013 Free PMC Article https://www.nejm.org/doi/full/10.1056/NEJMoa2002032 - Leung JM, Yang CX, Tam A et al ACE-2 Expression in the Small Airway Epithelia of Smokers and COPD Patients: Implications for COVID-19. European Respiratory Journal 2020. April PMID: 32269089 Free Article https://erj.ersjournals.com/content/early/2020/03/26/13993003.00688-2020
  130. Chow N et al. Preliminary estimates of the prevalence of selected underlying health conditions among patients with coronavirus disease 2019 - United States, February 12-March 28, 2020. MMWR Morb Mortal Wkly Rep 2020 Apr 3; 69:382. https://www.cdc.gov/mmwr/volumes/69/wr/mm6913e2.htm
  131. Guo T, Fan Y, Chen M et al. Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19). JAMA Cardiol 2020 Mar 27; PMID: 32219356 Free PMC Article https://jamanetwork.com/journals/jamacardiology/fullarticle/2763845
  132. Mao L; Jin H, Wang M et al Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. JAMA Neurol. Published online April 10, 2020. PMID: 32275288 https://jamanetwork.com/journals/jamaneurology/fullarticle/2764549 - Pleasure SJ, Green AJ, Josephson SA The Spectrum of Neurologic Disease in the Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic Infection. Neurologists Move to the Frontlines. JAMA Neurol. Published online April 10, 2020. PMID: 32275291 https://jamanetwork.com/journals/jamaneurology/fullarticle/2764548
  133. Grein J, Ohmagari N, Shin D et al Compassionate Use of Remdesivir for Patients with Severe Covid-19. N Engl J Med. April 10, 2020 PMID: 32275812 https://www.nejm.org/doi/full/10.1056/NEJMoa2007016 - National Institutes of Health NIH clinical trial of remdesivir to treat COVID-19 begins News Release. Feb 25, 2020 https://www.nih.gov/news-events/news-releases/nih-clinical-trial-remdesivir-treat-covid-19-begins - Beigel JH, Tomashek KM, Dodd LE et al Remdesivir for the Treatment of Covid-19 - Preliminary Report. N Engl J Med. May 22, 2020 PMID: 32445440 https://www.nejm.org/doi/full/10.1056/NEJMoa2007764?query=C19&cid=DM92280_NEJM_Subscriber&bid=200565854
  134. San Diego Zoo Global ZooNooz. Jan 11, 2021 Gorilla Troop at the San Diego Zoo Safari Park Test Positive for COVID-19. https://zoonooz.sandiegozoo.org/2021/01/11/gorilla-troop-at-the-san-diego-zoo-safari-park-test-positive-for-covid-19/
  135. Kincaid E COVID-19 Daily: Noninvasive Ventilation Support, 'Terrified' in ICU Medscape - Apr 07, 2020 https://www.medscape.com/viewarticle/928328
  136. Caly L, Druce JD, Catton MG et al The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro. Antiviral Research. Published online April 3, 2020 PMID: 32251768 Free PMC Article https://www.sciencedirect.com/science/article/pii/S0166354220302011 - FDA Safety information. April 10, 2020 Ivermectin Intended for Animals: Letter to Stakeholders - Do Not Use in Humans as a Treatment for COVID-19. https://www.fda.gov/safety/medical-product-safety-information/ivermectin-intended-animals-letter-stakeholders-do-not-use-humans-treatment-covid-19
  137. Galloway SE, Paul P, MacCannell DR, et al. Emergence of SARS-CoV-2 B.1.1.7 Lineage - United States, December 29, 2020 - January 12, 2021. MMWR Morb Mortal Wkly Rep. ePub: 15 January 2021 PMID: 33476315 Free article https://www.cdc.gov/mmwr/volumes/70/wr/mm7003e2.htm
  138. Sanders JM, Monogue ML, Jodlowski TZ et al Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19). A Review. JAMA. Published online April 13, 2020 PMID: 32282022 https://jamanetwork.com/journals/jama/fullarticle/2764727
  139. Zimmer C New California Variant May Be Driving Virus Surge There, Study Suggest New York Times. Jan 19, 2021 https://www.nytimes.com/2021/01/19/health/coronavirus-variant-california.html - By City News Service, Jan 18, 2021 New Coronavirus Strain Found in More Than One-Third of Cases in Cedars-Sinai Study. https://www.nbclosangeles.com/news/local/new-coronavirus-strain-cedars-sinai-los-angeles-covid-19-surge/2508635/ - Zhang W, Davis BD, Chen SS et al Emergence of a Novel SARS-CoV-2 Variant in Southern California. JAMA. Published online February 11, 2021 PMID: 33571356 https://jamanetwork.com/journals/jama/fullarticle/2776543 - Mascola ER, Graham BS, Fauci AS SARS-CoV-2 Viral Variants - Tackling a Moving Target. JAMA. Published online February 11, 2021 PMID: 33571363 https://jamanetwork.com/journals/jama/fullarticle/2776542
  140. Bruce A, Smout A British PM Says New Variant May Carry Higher Risk of Death. Medscape - Jan 22, 2021. https://www.medscape.com/viewarticle/944558 - Horby P, Huntley C, Davies N NERVTAG note on B.1.1.7 severity SAGE meeting paper. Jan 21, 2021 https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/955239/NERVTAG_paper_on_variant_of_concern__VOC__B.1.1.7.pdf
  141. Kissler SM, Tedijanto C, Goldstein E et al Projecting the transmission dynamics of SARS-CoV-2 through the postpandemic period. Science 14 Apr 2020: PMID: 32291278 https://science.sciencemag.org/content/early/2020/04/14/science.abb5793
  142. Ellis R CDC Says Three COVID-19 Symptoms Are Most Common. Medscape - Jul 17, 2020 https://www.medscape.com/viewarticle/934154
  143. McNamara D Unexpected: Higher Viral Loads Seen in Less Severe COVID-19. Medscape - Jul 17, 2020. https://www.medscape.com/viewarticle/934147
  144. He X, Lau EH, Wu P et al Temporal dynamics in viral shedding and transmissibility of COVID-19. Nature Medicine. 2020 April 15. PMID: 32296168 https://www.nature.com/articles/s41591-020-0869-5
  145. Young K, Sofair A, Chavey WE COVID-19: Smoking / Convalescent Plasma / Asthma / Poison Control Center Calls. Physician's First Watch, April 16, 2020 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org - Hakim D Asthma Is Absent Among Top Covid-19 Risk Factors, Early Data Shows. New York Times. April 16, 2020 https://www.nytimes.com/2020/04/16/health/coronavirus-asthma-risk.html - Broadhurst R et al Asthma in COVID-19 Hospitalizations: An Overestimated Risk Factor? Ann Am Thorac Soc 2020 Aug 31 PMID: 32864985 https://www.atsjournals.org/doi/pdf/10.1513/AnnalsATS.202006-613RL - Terry PD, Heidel RE, Dhand R Asthma in Adult Patients with COVID-19: Prevalence and Risk of Severe Disease. Am J Respir Crit Care Med (AJRCCM) 2021, Jan 15 PMID: 33493416 https://www.atsjournals.org/doi/abs/10.1164/rccm.202008-3266OC - Boyles S Asthma Patients Get Reassurance on COVID-19 - Research review finds no firm evidence of increased risk for severe illness, death. MedPage Today - Infectious Disease > COVID-19. Jan 28, 2021 https://www.medpagetoday.com/infectiousdisease/covid19/90934 - Centers for Disease Control & Prevention (CDC) People with Moderate to Severe Asthma. Risk of Severe Illness from COVID-19. https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/asthma.html
  146. AMA Morning News. January 26, 2021 American Medical Association
  147. Bangalore S, Sharma A, Slotwiner A et al ST-Segment Elevation in Patients with Covid-19 - A Case Series. N Engl J Med. April 17, 2020 PMID: 32302081 https://www.nejm.org/doi/full/10.1056/NEJMc2009020
  148. Toscano G, Palmerini F, Ravaglia S et al Guillain-Barre Syndrome Associated with SARS-CoV-2. N Engl J Med. April 17, 2020 PMID: 32302082 https://www.nejm.org/doi/full/10.1056/NEJMc2009191?query=RP - Zhao H, Shen D, Zhou H, Liu J, Chen S. Guillain-Barre syndrome associated with SARS-CoV-2 infection: causality or coincidence? Lancet Neurol. 2020 Apr 1. PMID: 32246917
  149. Su H, Yang M, Wan C et al Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. Kidney Int. 2020 Apr 9 PMID: 32327202 https://www.kidney-international.org/article/S0085-2538(20)30369-0/fulltext
  150. Leung NHL, Chu DKW, Shiu EYC et al. Respiratory virus shedding in exhaled breath and efficacy of face masks. Nat Med 2020 Apr 2; [e-pub]. PMID: 32371934 https://www.nature.com/articles/s41591-020-0843-2
  151. Dweck MR, Bularga A, Hahn RT et al Global evaluation of echocardiography in patients with COVID-19 Eur Heart J Cardiovasc Imaging. 2020 Jun 18:jeaa178 PMID: 32556199 Free PMC article https://academic.oup.com/ehjcimaging/article/doi/10.1093/ehjci/jeaa178/5859292
  152. Somers EC, Eschenauer GA, Troost JP Tocilizumab for treatment of mechanically ventilated patients with COVID-19. Clinical Infectious Diseases, ciaa954, Published: July 11, 2020 PMID: 32651997 https://academic.oup.com/cid/article/doi/10.1093/cid/ciaa954/5870306
  153. Ledford H How does COVID-19 kill? Uncertainty is hampering doctors' ability to choose treatments. Nature, NEWS 09 April 2020 https://www.nature.com/articles/d41586-020-01056-7 - Xu X, Han M, Li T et al. Effective treatment of severe COVID-19 patients with tocilizumab. Proc Natl Acad Sci U S A 2020 Apr 29; PMID: 32350134 https://www.pnas.org/content/early/2020/04/27/2005615117
  154. Broyd N Nicky Broyd. Oxford COVID-19 Vaccine Trial 'Within Weeks': Q&A - Medscape - Apr 18, 2020 https://www.medscape.com/viewarticle/928941
  155. NIH Coronavirus Disease 2019 (COVID-19) Treatment Guidelines. Updated. April 21, 2020 https://covid19treatmentguidelines.nih.gov/ - Alhazzani W et al. Surviving sepsis campaign: Guidelines on the management of critically ill adults with coronavirus disease 2019 (COVID-19). Crit Care Med 2020 Mar 27 https://journals.lww.com/ccmjournal/Abstract/9000/Surviving_Sepsis_Campaign__Guidelines_on_the.95707.aspx - Wilson KC et al. COVID-19: Interim guidance on management pending empirical evidence; from an American Thoracic Society-led international task force. 2020 Apr 3 https://www.thoracic.org/covid/covid-19-guidance.pdf - Bhimraj A et al. Infectious Diseases Society of America guidelines on the treatment and management of patients with COVID-19. 2020 Apr 11 https://www.idsociety.org/practice-guideline/covid-19-guideline-treatment-and-management
  156. Moore JP, Offit PA SARS-CoV-2 Vaccines and the Growing Threat of Viral Variants. JAMA. Published online January 28, 2021 PMID: 33507218 https://jamanetwork.com/journals/jama/fullarticle/2776039
  157. Walker M, HCQ Tied to Increased Mortality in Male Vets With Severe COVID-19. - But no difference in risk of ventilation versus patients not treated with drug.RR=2.6 MedPage Today April 21, 2020 https://www.medpagetoday.com/infectiousdisease/covid19/86082 - Magagnoli J, Narendran S, Pereira F et al Outcomes of hydroxychloroquine usage in United States veterans hospitalized with Covid-19. medRxiv 2020. April 21. https://www.medrxiv.org/content/10.1101/2020.04.16.20065920v1 - FDA News Release. April 24, 2020 Coronavirus (COVID-19) Update: FDA Reiterates Importance of Close Patient Supervision for 'Off-Label' Use of Antimalarial Drugs to Mitigate Known Risks, Including Heart Rhythm Problems. https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-reiterates-importance-close-patient-supervision-label-use - AMA Morging Rounds. July 14, 2020 - Sakoulas G, El Sahly H, Ellison RT III. Chloroquine and Hydroxychloroquine: Old Drugs in A New COVID-19 World. NEJM Journal Watch. April 24, 2020 Massachusetts Medical Society (subscription needed) http://www.jwatch.org - Guastalegname M, Vallone A Could Chloroquine /Hydroxychloroquine Be Harmful in Coronavirus Disease 2019 (COVID-19) Treatment? Clin Infect Dis. 2020 Mar 24. PMID: 32211771 - Yazdany J, Kim AHJ. Use of Hydroxychloroquine and Chloroquine During the COVID-19 Pandemic: What Every Clinician Should Know. Ann Intern Med. 2020 Mar 31. PMID: 32232419 Free PMC Article https://annals.org/aim/fullarticle/2764199/use-hydroxychloroquine-chloroquine-during-covid-19-pandemic-what-every-clinician - Damle B, Vourvahis M, Wang E et al Clinical Pharmacology Perspectives on the Antiviral Activity of Azithromycin and Use in COVID-19. Clin Pharmacol Ther. 2020 Apr 17.Review. PMID: 32302411 - Sinha N, Balayla G. Hydroxychloroquine and covid-19. Postgrad Med J. 2020 Apr 15. PMID: 32295814 - Alia E, Grant-Kels JM. Does Hydroxychloroquine Combat COVID-19? A Timeline of Evidence. J Am Acad Dermatol. 2020 Apr 10. PMID: 32283236 Free PMC Article
  158. Phend C CT Useless for COVID-19 Diagnosis, Study Affirms. - Even AI couldn't tell flu pneumonia from COVID in chest scans. MedPage Today July 12, 2020 https://www.medpagetoday.com/infectiousdisease/covid19/87526 - Lin L, Fu G, Chen S et al CT Manifestations of Coronavirus Disease (COVID-19) Pneumonia and Influenza Virus Pneumonia: A Comparative Study American Journal of Roentgenology: 1-9. 10.2214/AJR.20.2330 PMID: 32755175 https://www.ajronline.org/doi/full/10.2214/AJR.20.23304 - Han R, Huang L, Jiang H, Dong J, Peng H, Zhang D. Early Clinical and CT Manifestations of Coronavirus Disease 2019 (COVID-19) Pneumonia. AJR Am J Roentgenol. 2020 Mar 17:1-6. PMID: 32181672
  159. Ntaios G, Michel P, Georgiopoulos G et al Characteristics and Outcomes in Patients With COVID-19 and Acute Ischemic Stroke. The Global COVID-19 Stroke Registry. Stroke. July 9, 2020 PMID: 32787707 https://www.ahajournals.org/doi/10.1161/STROKEAHA.120.031208
  160. Carfi et al Persistent Symptoms in Patients After Acute COVID-19. JAMA. Published online July 9, 2020 PMID: 32644129 https://jamanetwork.com/journals/jama/fullarticle/2768351 - Chopra V, Flanders SA. O'Malley M et al. Sixty-day outcomes among patients hospitalized with COVID-19. Ann Intern Med 2020 Nov 11 PMID: 33175566 PMCID: PMC7707210 Free PMC article https://www.acpjournals.org/doi/10.7326/M20-5661
  161. Rubin GD, Ryerson CJ, Haramati LB et al. The role of chest imaging in patient management during the COVID-19 pandemic: A multinational consensus statement from the Fleischner Society. Chest 2020 Apr 7; https://journal.chestnet.org/article/S0012-3692(20)30673-5/pdf
  162. Jancin B COVID-19 Panel: Helmet CPAP, Pronation Key Tools for Some Patients. Medscape - Apr 23, 2020. https://www.medscape.com/viewarticle/929285
  163. Walker M. Remdesivir Fails in Severe COVID-19 Trial in China. No clinical benefit between groups in randomized trial, mistakenly released data show. MedPage Today April 23, 2020
  164. Puntmann VO, Carerj ML, Wieters T et al Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19) JAMA Cardiol. Published online July 27, 2020 PMID: 32730619 https://jamanetwork.com/journals/jamacardiology/fullarticle/2768916 - Lindner D,Fitzek A, Brauninger H et al Association of Cardiac Infection With SARS-CoV-2 in Confirmed COVID-19 Autopsy Cases. JAMA Cardiol. Published online July 27, 2020 PMID: 32730555 https://jamanetwork.com/journals/jamacardiology/fullarticle/2768914 - Yancy CW, Fonarow DC Coronavirus Disease 2019 (COVID-19) and the Heart - Is Heart Failure the Next Chapter? JAMA Cardiol. Published online July 27, 2020 PMID: 32730614 https://jamanetwork.com/journals/jamacardiology/fullarticle/2768915
  165. Harrison L Proton Pump Inhibitors Tied to COVID-19 Risk. Medscape - Jul 09, 2020. https://www.medscape.com/viewarticle/933645 - Almario CV, Chey WD, Spiegel BMR Increased Risk of COVID-19 Among Users of Proton Pump Inhibitors. American Journal of Gastroenterology. July 7, 2020 PMID: 32852340 https://journals.lww.com/ajg/Documents/AJG-20-1811_R1(PUBLISH%20AS%20WEBPART).pdf - Lee SW, Ha EK, Yeniova AO et al Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching. Gut. 2020 Jul 30:gutjnl-2020-322248. PMID: 32732368
  166. Kaplan S, Achenbach J This coronavirus mutation has taken over the world. Scientists are trying to understand why. Washington Post. June 29 https://www.washingtonpost.com/science/2020/06/29/coronavirus-mutation-science/ - Carey B Did a Mutation Help the Coronavirus Spread? More Evidence, but Lingering Questions. New York Times. July 2, 2020 https://www.msn.com/en-us/health/health-news/did-a-mutation-help-the-coronavirus-spread-more-evidence-but-lingering-questions/ar-BB16gfDe?li=BBnb7Kz - Korber B et al Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2. bioRxiv. May 05, 2020 https://www.biorxiv.org/content/10.1101/2020.04.29.069054v2 - Zhang L et al The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivity. bioRxiv. June 12, 2020 https://www.biorxiv.org/content/10.1101/2020.06.12.148726v1 - Olena A SARS-CoV-2 Genetic Variant May Be More Transmissible. The Scientist. Nove 25, 2020 https://www.the-scientist.com/news-opinion/sars-cov-2-genetic-variant-may-be-more-transmissible-68201
  167. Fiore K. COVID-19: Not Your Typical ARDS? - Experts weigh in on popular theories about HAPE, PEEP, and clotting. MedPage Today April 20, 2020 https://www.medpagetoday.com/infectiousdisease/covid19/86046
  168. George J Seizures and COVID-19 - Italian case suggests breakthrough seizures may indicate infection MedPage Today April 23, 2020 https://www.medpagetoday.com/infectiousdisease/covid19/86118 - Vollono C, Rollo E, Romozzi M et al Focal status epilepticus as unique clinical feature of COVID-19: a case report. Seizure. April 21, 2020 PMID: 32344366 Free PMC Article https://www.seizure-journal.com/article/S1059-1311(20)30115-1/fulltext - Lu L, Xiong W, Liu D et al New-onset acute symptomatic seizure and risk factors in Corona Virus Disease 2019: A Retrospective Multicenter Study. Epilepsia. April 18, 2020 PMID: 32304092 https://onlinelibrary.wiley.com/doi/abs/10.1111/epi.16524
  169. Myers LC, Parodi SM, Escobar GJ et al Characteristics of Hospitalized Adults With COVID-19 in an Integrated Health Care System in California JAMA. Published online April 24, 2020 PMID: 32329797 https://jamanetwork.com/journals/jama/fullarticle/2765303
  170. McNamara D COVID-19 Linked to Large Vessel Stroke in Young Adults. Medscape - Apr 24, 2020 https://www.medscape.com/viewarticle/929345
  171. World Health Organization (WHO). April 24, 2020 "Immunity passports" in the context of COVID-19. https://www.who.int/news-room/commentaries/detail/immunity-passports-in-the-context-of-covid-19
  172. Goodman B COVID-19 Lung Problems May Start in Blood Vessels Medscape - Apr 27, 2020 https://www.medscape.com/viewarticle/929496
  173. Graham J Seniors With COVID-19 Show Unusual Symptoms, Doctors Say. Medscape - Apr 27, 2020 https://www.medscape.com/viewarticle/929407
  174. Ward CF, Figiel GS, McDonald WM et al. Altered mental status as a novel initial clinical presentation for COVID-19 infection in the elderly. Am J Geriatr Psychiatry 2020 Aug; 28:808. PMID: 32425470 PMCID: PMC7227566 Free PMC article https://www.sciencedirect.com/science/article/pii/S1064748120303420 - AMA Morning Rounds. Nov 20, 2020
  175. Stauffer WM, Alpern JD, Walker PF COVID-19 and Dexamethasone. A Potential Strategy to Avoid Steroid- Related Strongyloides Hyperinfection. JAMA. Published online July 30, 2020 PMID: 32761166 https://jamanetwork.com/journals/jama/fullarticle/2769100
  176. Jering KS et al. Clinical characteristics and outcomes of hospitalized women giving birth with and without COVID-19. JAMA Intern Med 2021 Jan 15 PMID: 33449067 https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2775396
  177. Larkin M Viral Shedding Continues Up to 6 Weeks After Coronavirus Symptom Onset. Medscape - Apr 27, 2020 https://www.medscape.com/viewarticle/929519
  178. Ingram I Anti-CD20 Drugs Tied to Severe COVID in Cancer Patients - Plus: Active chemo treatment may not be a COVID risk factor. MedPage Today February 5, 2021 https://www.medpagetoday.com/hematologyoncology/lymphoma/91092
  179. Reyes Gil M, Barouqa M, Szymanski J et al Assessment of Lupus Anticoagulant Positivity in Patients With Coronavirus Disease 2019 (COVID-19). JAMA Netw Open. 2020;3(8):e2017539. August 12, 2020 PMID: 32785632 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2769229
  180. Restivo DA, Centonze D, Alesina A, Marchese-Ragona R. Myasthenia Gravis Associated With SARS-CoV-2 Infection. Ann Intern Med. Aug 10, 2020 PMID: 32776781 https://www.acpjournals.org/doi/10.7326/L20-0845
  181. Wang QQ, David PB, Gurney ME, Xu R COVID-19 and dementia: Analyses of risk, disparity, and outcomes from electronic health records in the US. Alzheimer's & Dementia. 2021. Feb 9 PMID: 33559975 https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12296
  182. Young K, Sofair A, Chavey WE COVID-19: Positive Retests / Federal Prisons / Mental Health / Miscarriage. Physician's First Watch, April 30, 2020 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org - Czachor E SOUTH KOREA EXPERTS SAY RECOVERED CORONAVIRUS PATIENTS RETESTED POSITIVE BECAUSE OF 'DEAD' VIRUS PARTS. Newsweek. April 29, 2020 https://www.newsweek.com/south-korea-experts-say-recovered-coronavirus-patients-retested-positive-because-dead-virus-parts-1500998
  183. Russell P Study Suggests a Third of COVID-19 Hospital Patients May Die. Medscape - Apr 30, 2020. https://www.medscape.com/viewarticle/929701
  184. Mehra MR, Desai SS, Kuy S et al Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19. N Engl J Med. May 1, 2020 PMID: 32356626 https://www.nejm.org/doi/full/10.1056/NEJMoa2007621 * authors associated with Surgisphere implicated in false data *
  185. Orciari Herman A, Sadoughi S, Sofair A COVID Toe Physician's First Watch, May 4, 2020 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org - Rabin RC What Is 'Coovid Toe'? Maybe a Strange Sign of Coronavirus Infection. New York Times. May 1m 2020 https://www.nytimes.com/2020/05/01/health/coronavirus-covid-toe.html - Kirkner RM Chilblain-like lesions reported in children thought to have COVID-19. MDedge: Dermatology News. May 21, 2020 https://www.mdedge.com/dermatology/article/222546/coronavirus-updates/chilblain-lesions-reported-children-thought-have - Colonna C, Monzani NA, Rocchi A et al Chilblains-like lesions in children following suspected Covid-19 infection. Pediatric Dermatology. May 6, 2020 PMID: 32374033 https://onlinelibrary.wiley.com/doi/abs/10.1111/pde.14210
  186. Bosworth T Heterogeneity Seen in COVID-19 Skin Manifestations Medscape - May 05, 2020. https://www.medscape.com/viewarticle/929996
  187. Mallapaty S How sewage could reveal true scale of coronavirus outbreak. Wastewater testing could also be used as an early-warning sign if the virus returns. Nature, NEWS 03 April 2020 https://www.nature.com/articles/d41586-020-00973-x - Fiore K As Indiana Reopens, One City Scans Sewage for Guidance. On the frontier of "wastewater epidemiology". MedPage Today May 7, 2020 https://www.medpagetoday.com/infectiousdisease/covid19/86352 - Nattino G, Castiglioni S, Cereda D et al Association Between SARS-CoV-2 Viral Load in Wastewater and Reported Cases, Hospitalizations, and Vaccinations in Milan, March 2020 to November 2021. JAMA. Published online April 1, 2022 PMID: 35363259 https://jamanetwork.com/journals/jama/fullarticle/2790911 - Varkila MR, Montez-Rath ME, Salomon JA et al Use of Wastewater Metrics to Track COVID-19 in the US. JAMA Netw Open. 2023;6(7):e2325591 PMID: 37494040 PMCID: PMC10372707 Free PMC article https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2807632
  188. Helms J, Kremer S, Merdji H et al. Neurologic features in severe SARS-CoV-2 infection. N Engl J Med 2020 Apr 15; PMID: 32294339 Free PMC Article https://www.nejm.org/doi/10.1056/NEJMc2008597
  189. Abbasi J Researchers Investigate What COVID-19 Does to the Heart JAMA. Published online February 10, 2021 PMID: 33566089 https://jamanetwork.com/journals/jama/fullarticle/2776538 - Beck DL Myocardial Injury Seen on MRI in 54% of Recovered COVID Medscape - Feb 23, 2021 https://www.medscape.com/viewarticle/946287
  190. Orciari Herman A, Sadoughi S, Saitz R COVID-19: Multisystem Inflammatory Syndrome, Physician's First Watch, May 6, 2020 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org - Belluck P A New Coronavirus Threat to Children. New York Times. May 6, 2020 https://www.nytimes.com/2020/05/06/health/kawasaki-disease-covid-coronavirus-children.html - Riphagen S, Gomez X, Gonzalez-Martinez C et al Hyperinflammatory shock in children during COVID-19 pandemic. Lancet May 7, 2020 PMID: 32386565 Free PMC Article https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31094-1/fulltext - Shekerdemian LS, Mahmood NR, Wolfe KK et al Characteristics and Outcomes of Children With Coronavirus Disease 2019 (COVID-19) Infection Admitted to US and Canadian Pediatric Intensive Care Units. JAMA Pediatr. Published online May 11, 2020. PMID: 32392288 https://jamanetwork.com/journals/jamapediatrics/fullarticle/2766037
  191. Rothaus C A Woman with a Lung Mass NEJM Resident 360. August 12, 2020 https://resident360.nejm.org/clinical-pearls/a-woman-with-a-lung-mass-2
  192. Walsh NK CNN Exclusive: WHO Wuhan mission finds possible signs of wider original outbreak in 2019. CNN Health. Feb 14, 2021 https://www.cnn.com/2021/02/14/health/who-mission-china-intl/index.html
  193. Wichmann D, Sperhake JP, Lutgehetmann M et al Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study. Ann Intern Med. 2020. May 6. PMID: 32374815 https://annals.org/aim/fullarticle/2765934/autopsy-findings-venous-thromboembolism-patients-covid-19-prospective-cohort-study
  194. Al-Samkari H, Karp Leaf RS, Dzik WH, Carlson JCT et al. COVID-19 and coagulation: Bleeding and thrombotic manifestations of SARS-CoV-2 infection. Blood 2020 Jul 23; 136:489 PMID: 32492712 Free PMC article. https://ashpublications.org/blood/article/136/4/489/460672/COVID-19-and-coagulation-bleeding-and-thrombotic
  195. George J COVID-19 Damage Seen in Olfactory System - Autopsy report shows direct SARS-CoV-2 infection in olfactory bulb cells. MedPage Today August 13, 2020 https://www.medpagetoday.com/infectiousdisease/covid19/88050 - Morbini P, Benazzo M, Verga L et al Ultrastructural Evidence of Direct Viral Damage to the Olfactory Complex in Patients Testing Positive for SARS-CoV-2. JAMA Otolaryngology, Aug 13, 2020 PMID: 32790835 https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2769496
  196. Universita di Bologna The six strains of SARS-CoV-2 Science News. Aug 3, 2020 https://www.sciencedaily.com/releases/2020/08/200803105246.htm
  197. Nicolai L, Leunig A, Brambs S et al. Immunothrombotic dysregulation in COVID-19 pneumonia is associated with respiratory failure and coagulopathy. Circulation 2020 Jul 28; [e-pub] PMID: 32755393 https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.048488
  198. COVID-19 risk calculator Calculation ToolFor Predicting Critical-ill COVID-19 At Admission http://118.126.104.170/ - Liang W, Liang H, Ou L et al Development and Validation of a Clinical Risk Score to Predict the Occurrence of Critical Illness in Hospitalized Patients With COVID-19. JAMA Intern Med. Published online May 12, 2020. PMID: 32396163 https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2766086
  199. Young BE, Fong SW, Chan YH et al Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study. Lancet. August 18, 2020 PMID: 32822564 PMCID: PMC7434477 Free PMC article https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31757-8/fulltext
  200. Brooks M 'Stronger' Evidence of Myocardial Injury in COVID-19 . Medscape - Apr 16, 2020. https://www.medscape.com/viewarticle/928863 - Dong N, Cai J, Zhou Y, Liu J, Li F End-stage Heart Failure with COVID-19: Strong Evidence of Myocardial Injury by 2019-nCoV. JACC: Heart Failure. April 7 2020 PMID: 32265149 Free PMC Article http://heartfailure.onlinejacc.org/content/early/2020/04/07/j.jchf.2020.04.001
  201. Hodcroft EB, Domman DB, Snyder DJ et al Emergence in late 2020 of multiple lineages of SARS-CoV-2 Spike protein variants affecting amino acid position 677. MedRxiv. Feb 14, 2021 Not indexed in PubMed https://www.medrxiv.org/content/10.1101/2021.02.12.21251658v2
  202. Takahashi T, Ellingson MK, Wong P et al Sex differences in immune responses that underlie COVID-19 disease outcomes. Nature. Aug 26, 2020 PMID: 32846427 https://www.nature.com/articles/s41586-020-2700-3_reference.pdf
  203. Kirkcaldy RD, King BA, Brooks JT COVID-19 and Postinfection Immunity. Limited Evidence, Many Remaining Questions. JAMA. Published online May 11, 2020. PMID: 32391855 https://jamanetwork.com/journals/jama/fullarticle/2766097
  204. Ferastraoaru D, Hudes G, Jerschow E Eosinophilia in Asthma Patients Is Protective Against Severe COVID-19 Illness. J Allergy Clin Immunol Pract. 2021 Jan 22:S2213-2198(20)31409-4. PMID: 33495097 Free PMC article.
  205. Lou N No-Lab Antigen Test; Don't Argue with Mask Refuseniks; Pandemic Child Predators. - A daily roundup of news on COVID-19 and the rest of medicine MedPage Today August 27, 2020 https://www.medpagetoday.com/infectiousdisease/covid19/88291
  206. BBC News May 12, 2020 Maria Branyas: 'Oldest woman in Spain' beats coronavirus at 113. https://www.bbc.com/news/world-europe-52641659
  207. Puelles VG, Lutgehetmann M, Lindenmeyer MT Multiorgan and Renal Tropism of SARS-CoV-2 N Engl J Med. May 13, 2020 PMID: 32402155 https://www.nejm.org/doi/full/10.1056/NEJMc2011400
  208. Wu P, Duan F, Luo C, Liu Q, Qu X, Liang L, Wu K. Characteristics of Ocular Findings of Patients With Coronavirus Disease 2019 (COVID-19) in Hubei Province, China. JAMA Ophthalmol. 2020;138(5):575-578 PMID: 32232433 Free PMC Article https://jamanetwork.com/journals/jamaophthalmology/fullarticle/2764083
  209. George J Surprise Find in COVID-19 Brain Capillaries - Could this contribute to COVID brain fog? MedPage Today February 17, 2021 https://www.medpagetoday.com/neurology/generalneurology/91246 - Nauen DW, Hooper JE, Stewart M, Solomon IH. Assessing Brain Capillaries in Coronavirus Disease 2019. JAMA Neurol. Published online February 12, 2021. PMID: 33576767 https://jamanetwork.com/journals/jamaneurology/fullarticle/2776455
  210. Russell P. Could Bio-detection Dogs Sniff Out COVID-19 Infection? Medscape - May 17, 2020 https://www.medscape.com/viewarticle/930652
  211. Shah P, Smith H, Olarewaju A et al. Is cardiopulmonary resuscitation futile in coronavirus disease 2019 patients experiencing in-hospital cardiac arrest? Crit Care Med 2021 Feb 1; 49:201 PMID: 33093278 https://journals.lww.com/ccmjournal/Fulltext/2021/02000/Is_Cardiopulmonary_Resuscitation_Futile_in.4.aspx
  212. Lax SF, Skok K, Zechner P et al Pulmonary Arterial Thrombosis in COVID-19 With Fatal Outcome: Results From a Prospective, Single-Center, Clinicopathologic Case Series. Annals of Internal Medicine, May 14, 2020 PMID: 32422076 https://www.acpjournals.org/doi/10.7326/M20-2566
  213. Hughes S Most Severe COVID Tied to Four Cardiometabolic Conditions. Medscape - Feb 25, 2021. https://www.medscape.com/viewarticle/946488
  214. Nedelman M, Lieber M cites Argulian E Right ventricle enlargement a major predictor for mortality among COVID patients, new study finds. CNN Health. May 18, 2020 https://www.cnn.com/2020/05/18/health/right-ventricle-enlargement-coronavirus/index.html
  215. Martinez MW, Tucker AM, Bloom OJ et al Prevalence of Inflammatory Heart Disease Among Professional Athletes With Prior COVID-19 Infection Who Received Systematic Return-to-Play Cardiac Screening. JAMA Cardiol. Published online March 4, 2021 PMID: 33662103 https://jamanetwork.com/journals/jamacardiology/fullarticle/2777308 - Daniels CJ, Rajpal S, Greenshields JT et al Prevalence of Clinical and Subclinical Myocarditis in Competitive Athletes With Recent SARS-CoV-2 Infection. Results From the Big Ten COVID-19 Cardiac Registry. JAMA Cardiol. 2021;6(9):1078-1087 PMID: 34042947 PMCID: PMC8160916 Free PMC article https://jamanetwork.com/journals/jamacardiology/fullarticle/2780548
  216. Harrison L Thrombosis Biomarkers Tied to COVID-19 Deaths Medscape - May 19, 2020 https://www.medscape.com/viewarticle/930804
  217. Reynolds AS, Lee AG, Renz J et al Pulmonary Vascular Dilatation Detected by Automated Transcranial Doppler in COVID-19 Pneumonia. Am J Respir Crit Care Med. August 06, 2020 PMID: 32757969 https://www.atsjournals.org/doi/pdf/10.1164/rccm.202006-2219LE
  218. Kompaniyets L, Goodman AB, Belay B, et al. Body Mass Index and Risk for COVID-19-Related Hospitalization, Intensive Care Unit Admission, Invasive Mechanical Ventilation, and Death - United States, March- December 2020. MMWR Morb Mortal Wkly Rep 2021;70:355-361 PMID: 33705371 https://www.cdc.gov/mmwr/volumes/70/wr/mm7010e4.htm
  219. Kox M; Waalders NJB, Kooistra EJ et al Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions. JAMA. Published online September 3, 2020 PMID: 32880615 https://jamanetwork.com/journals/jama/article-abstract/2770484
  220. Gleason J, Ross W, Fossi A et al The Devastating Impact of Covid-19 on Individuals with Intellectual Disabilities in the United States. NEJM Catalyst. March 5, 2021 Not indexed in PubMed https://catalyst.nejm.org/doi/full/10.1056/CAT.21.0051
  221. Bunyavanich S, Do A, Vicencio A Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults. JAMA. Published online May 20, 2020 PMID: 32432657 https://jamanetwork.com/journals/jama/fullarticle/2766524 - Patel AB, Verma A Nasal ACE2 Levels and COVID-19 in Children. JAMA. Published online May 20, 2020 PMID: 32208485 https://jamanetwork.com/journals/jama/fullarticle/2766522
  222. Walker M Vets Study Casts Doubt on Accepted COVID-19 Risk Factors - Neither race/ethnicity nor obesity found to contribute to mortality. MedPage Today September 23, 2020 https://www.medpagetoday.com/infectiousdisease/covid19/88776 - Ioannou GN, et al Risk factors for hospitalization, mechanical ventilation, or death among 10131 US veterans with SARS-CoV-2 infection. JAMA Netw Open. 2020;3(9):e2022310 PMID: 32965502 Free article. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2770946
  223. Ackermann M, Verleden SI, Kuehne M et al Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19. N Engl J Med. May 21, 2020 PMID: 32437596 https://www.nejm.org/doi/full/10.1056/NEJMoa2015432 - Hariri L, Hardin CC Covid-19, Angiogenesis, and ARDS Endotypes. N Engl J Med. May 21, 2020 PMID: 32437597 https://www.nejm.org/doi/full/10.1056/NEJMe2018629 - Skipper CP et al. Hydroxychloroquine in nonhospitalized adults with early COVID-19: A randomized trial. Ann Intern Med 2020 Jul 16; PMID: 32673060 Free PMC article. https://www.acpjournals.org/doi/10.7326/M20-4207 - Schluger NW. The saga of hydroxychloroquine and COVID-19: A cautionary tale. Ann Intern Med 2020 Jul 16; [e-pub]. PMID: 32673059 Free PMC article https://www.acpjournals.org/doi/10.7326/M20-5041
  224. Frontera, J.A., Melmed, K., Fang, T. et al. Toxic Metabolic Encephalopathy in Hospitalized Patients with COVID-19. Neurocrit Care (2021). PMID: 33725290 PMCID: PMC7962078 Free PMC article https://link.springer.com/article/10.1007/s12028-021-01220-5
  225. GE Healthcare. Aug 4, 2020 When Should You Take an ECG for a COVID-19 Patient https://www.gehealthcare.com/article/when-should-you-take-an-ecg-for-a-covid-19-patient
  226. Knight SR et al. Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: Development and validation of the 4C Mortality Score. BMJ 2020 Sep 9; 370:m3339 PMID: 32907855 https://www.bmj.com/content/370/bmj.m3339
  227. El Moheb M, Naar L, Christensen MA et al Gastrointestinal Complications in Critically Ill Patients With and Without COVID-19. JAMA. Published online September 24, 2020 PMID: 32970139 https://jamanetwork.com/journals/jama/fullarticle/2771160
  228. Worcester S Poor Survival With COVID in Patients Who Have Had HSCT Medscape - Mar 23, 2021. https://www.medscape.com/viewarticle/947920 - Sharma A, Bhatt NS, St Martin A et al Clinical characteristics and outcomes of COVID-19 in haematopoietic stem-cell transplantation recipients: an observational cohort study. Lancet Haematology. 2021 Mar 1. (published Jan 19, 2021) PMID: 33482113 PMCID: PMC7816949 Free PMC article https://www.thelancet.com/journals/lanhae/article/PIIS2352-3026(20)30429-4/fulltext - Leclerc M, Maury S A rationale to prioritise vaccination of HSCT patients against COVID-19, Lancet Haematology. 2021 Mar 1. (published Jan 19, 2021) Not indexed in PubMed https://www.thelancet.com/journals/lanhae/article/PIIS2352-3026(21)00008-9/fulltext
  229. Schaller T, Hirschbuhl K, Burkhardt K et al Postmortem Examination of Patients With COVID-19. JAMA. Published online May 21, 2020 PMID: 32437497 https://jamanetwork.com/journals/jama/fullarticle/2766557
  230. Lou N Code Blue for COVID-19 Patients: No Survivors - One group reports 100% mortality from IHCA during the pandemic. MedPage Today September 28, 2020 https://www.medpagetoday.com/infectiousdisease/covid19/88855 - Thapa SB, et al Clinical outcomes of in-hospital cardiac arrest in COVID-19. JAMA Intern Med 2020. Sept 28 https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2771090 - Modes ME, et al Outcomes of cardiopulmonary resuscitation in patients with COVID-19 -- limited data, but further reason for action. JAMA Intern Med 2020. September 28 https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2771089 - Hayek SS et al. In-hospital cardiac arrest in critically ill patients with covid-19: Multicenter cohort study. BMJ 2020 Oct 1; 371:m3513. PMID: 32998872 PMCID: PMC7525342 Free PMC article https://www.bmj.com/content/371/bmj.m3513
  231. Kuo CL, Pilling LC, Atkins J: et al APOE e4 genotype predicts severe COVID-19 in the UK Biobank community cohort. The Journals of Gerontology: Series A, glaa131. May 26, 2020 PMID: 32451547 https://academic.oup.com/biomedgerontology/advance-article/doi/10.1093/gerona/glaa131/5843454
  232. Leichien JR et al Loss of Smell and Taste in 2013 European Patients With Mild to Moderate COVID-19. Annals of Internal Medicine. May 26, 2020 PMID: 32449883 https://www.acpjournals.org/doi/10.7326/M20-2428 - Menni C et al. Real-time tracking of self-reported symptoms to predict potential COVID-19. Nat Med 2020 Jul; 26:1037 PMID: 32393804 https://www.nature.com/articles/s41591-020-0916-2
  233. Boldrini M, Canoll PD, Klein RS How COVID-19 Affects the Brain. JAMA Psychiatry. 2021. March 26. https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2778090
  234. Swift Yasgur B Mental Illness Tied to Increased Mortality in COVID-19 /. Medscape - Sep 30, 2020 https://www.medscape.com/viewarticle/938347
  235. Solerte SB et al Sitagliptin Treatment at the Time of Hospitalization Was Associated With Reduced Mortality in Patients With Type 2 Diabetes and COVID-19: A Multicenter, Case-Control, Retrospective, Observational Study. Diabetes Care. 2020 Sep 29:dc201521 PMID: 32994187
  236. Liotta EM et al Frequent neurologic manifestations and encephalopathy-associated morbidity in Covid-19 patients. Annals of Clinical and Translational Neurology. Oct 5, 2020 PMID: 33016619 Free article. https://onlinelibrary.wiley.com/doi/full/10.1002/acn3.51210
  237. Nahum J, Morichau-Beauchant T, Daviaud F et al Venous Thrombosis Among Critically Ill Patients With Coronavirus Disease 2019 (COVID-19). JAMA Netw Open. 2020;3(5):e2010478. May 29 PMID: 32469410 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2766543
  238. Zubair AS, McAlpine LS, Gardin T et al Neuropathogenesis and Neurologic Manifestations of the Coronaviruses in the Age of Coronavirus Disease 2019. A Review. JAMA Neurol. Published online May 29, 2020 PMID: 32469387 https://jamanetwork.com/journals/jamaneurology/fullarticle/2766766
  239. Tucker ME CDC Adds New Medical Conditions to COVID-19 High-Risk List Medscape - Mar 31, 2021 https://www.medscape.com/viewarticle/948445
  240. Cariou B, Hadjadj S, Wargny M et al Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study. Diabetologia. May 2020 PMID: 32472191 Free PMC article https://diabetologia-journal.org/wp-content/uploads/2020/05/Cariou.pdf
  241. Argenziano AG, Bruce SL, Slater CL et al Characterization and clinical course of 1000 patients with coronavirus disease 2019 in New York: retrospective case series. BMJ 2020;369:m1996 PMID: 32471884 Free article https://www.bmj.com/content/369/bmj.m1996
  242. Ahmad FB, Anderson RN The Leading Causes of Death in the US for 2020. JAMA. Published online March 31, 2021. PMID: 33787821 https://jamanetwork.com/journals/jama/fullarticle/2778234
  243. Worsham CM, Banzett RB, Schwartzstein R Air Hunger and Psychological Trauma in Ventilated COVID-19 Patients: An Urgent Problem. Annals of the American Thoracic Society June 2020 PMID: 32501114 https://www.thoracic.org/about/newsroom/press-releases/resources/air-hunger-and-psychological-trauma-in-covid1.pdf
  244. Ellis R COVID-19 Infection Fatality Ratio Is About 1.15%, Study Says Medscape - Oct 30, 2020. https://www.medscape.com/viewarticle/940087 - Imperial College of London. Report 34 - COVID-19 Infection Fatality Ratio Estimates from Seroprevalence. COVID-19 deaths: Infection fatality ratio is about 1% says new report. https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/covid-19/report-34-IFR/ https://www.imperial.ac.uk/news/207273/covid19-deaths-infection-fatality-ratio-says/
  245. Ayoubkhani D, Khunti K, Nafilyan V et al Post-covid syndrome in individuals admitted to hospital with covid-19: retrospective cohort study. BMJ 2021;372:n693 PMID: 33789877 https://www.bmj.com/content/372/bmj.n693
  246. Gandhi RT, Lynch JB, del Rio C. Mild or moderate Covid-19. N Engl J Med; 2020 Apr 24 [e-pub]. PMID: 32329974 https://www.nejm.org/doi/10.1056/NEJMcp2009249 - Berlin DA, Gulick RM, Martinez FJ Severe Covid-19. N Engl J Med 2020 May 15; [e-pub]. PMID: 32412710 https://www.nejm.org/doi/10.1056/NEJMcp2009575
  247. Woolf SH, Chapman DA, Sabo RT et al Excess Deaths From COVID-19 and Other Causes in the US, March 1, 2020, to January 2, 2021. JAMA. Published online April 2, 2021 PMID: 33797550 https://jamanetwork.com/journals/jama/fullarticle/2778361 - Garber AM Learning From Excess Pandemic Deaths. JAMA. Published online April 2, 2021 PMID: 33797557 https://jamanetwork.com/journals/jama/fullarticle/2778362
  248. McNeil DG Jr A nasal spray prevented Covid-19 infection in ferrets, a study finds. New York Times. Nov 6, 2020 via MSN News https://www.msn.com/en-us/news/world/a-nasal-spray-prevented-covid-19-infection-in-ferrets-a-study-finds/ar-BB1aLJne - de Vries RD, Schmitz KS, Bovier FT et al Intranasal fusion inhibitory lipopeptide prevents direct contact SARS-CoV-2transmissionin ferrets. bioRxiv preprint. Nov 5, 2020 https://www.biorxiv.org/content/10.1101/2020.11.04.361154v1.full.pdf - de Vries RD, Schmitz KS, Bovier FT et al Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets. Science 2021. Feb 17 PMID: 33597220 https://science.sciencemag.org/content/early/2021/02/16/science.abf4896
  249. Romero-Sanchez CM, Diaz-Maroto I, Fernandez-Diaz E et al Neurologic manifestations in hospitalized patients with COVID-19: The ALBACOVID registry. Neurology, June 1, 2020 PMID: 32482845 https://n.neurology.org/content/early/2020/06/01/WNL.0000000000009937.full
  250. Mehta HB, Li S, Goodwin JS. Risk Factors Associated With SARS-CoV-2 Infections, Hospitalization, and Mortality Among US Nursing Home Residents. JAMA Netw Open. 2021;4(3):e216315. PMID: 33787905 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2777972
  251. Szekely Y et al. The spectrum of cardiac manifestations in coronavirus disease 2019 (COVID-19) - A systematic echocardiographic study. Circulation 2020 May 29; [e-pub] PMID: 32469253 https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.047971
  252. Metz TD, Clifton RG, Hughes BL et al. Disease severity and perinatal outcomes of pregnant patients with coronavirus disease 2019 (COVID-19). Obstet Gynecol 2021 Apr 1; 137:571. PMID: 33560778 PMCID: PMC7984765 Free PMC article https://journals.lww.com/greenjournal/Abstract/2021/04000/Disease_Severity_and_Perinatal_Outcomes_of.3.aspx
  253. Munnink BBO, Sikkema RS, Nieuwenhuijse DF et al Transmission of SARS-CoV-2 on mink farms between humans and mink and back to humans. Science 2020. Nov 10 PMID: 33172935 https://science.sciencemag.org/content/early/2020/11/09/science.abe5901
  254. Parasa S, Desai M, Chandrasekar VT et al Prevalence of Gastrointestinal Symptoms and Fecal Viral Shedding in Patients With Coronavirus Disease 2019. A Systematic Review and Meta-analysis. JAMA Netw Open. 2020;3(6):e2011335. PMID: 32525549 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2767009
  255. Bastard P, Rosen LB, Zhang Q wt al Autoantibodies against type I IFNs in patients with life-threatening COVID-19. Science 2020. Oct 23 PMID: 32972996 https://science.sciencemag.org/content/370/6515/eabd4585 - Zhang Q, Bastard P, Liu Z et al Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Science 2020. Oct 23 PMID: 32972995 https://science.sciencemag.org/content/370/6515/eabd4570
  256. Vlessides M Can Mouthwash Douse the Spread of COVID-19? Medscape - Jun 12, 2020. https://www.medscape.com/viewarticle/932214 - Kirk-Bayley J et al The Use of Povidone Iodine Nasal Spray and Mouthwash During the Current COVID-19 Pandemic May Reduce Cross Infection and Protect Healthcare Workers. SSRN. May 4, 2020 https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3563092 https://ssrn.com/abstract=3563092 http://dx.doi.org/10.2139/ssrn.3563092
  257. Chan PS, Girotra S, Tang Y et al Outcomes for Out-of-Hospital Cardiac Arrest in the United States During the Coronavirus Disease 2019 Pandemic. JAMA Cardiol. Published online November 14, 2020 PMID: 33188678 https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2020.6210
  258. Anderson JL et al. Association of sociodemographic factors and blood group type with risk of COVID-19 in a US population. JAMA Netw Open 2021 Apr 5; 4:e217429. PMID: 33818622 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2778155
  259. Edmonds S 'Beyond a Reasonable Doubt': COVID-19 Brain Health Fallout Is Real, Severe Medscape - Apr 07, 2021. https://www.medscape.com/viewarticle/948882 - Taquet M, Geddes JR, Husain M et al 6-month neurological and psychiatric outcomes in 236,379 survivors of COVID-19: a retrospective cohort study using electronic health records. The Lancet Psychiatry. April 6, 2021 PMID: 33836148 PMCID: PMC8023694 Free PMC article https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(21)00084-5/fulltext et al
  260. American Medical Assoociation (AMA) AMA Morning Rounds. May 27, 2021 - Dan JM, Mateus J, Kato Y et al Immunological memory to SARS-CoV-2 assessed for greater than six months after infection. bioRxiv. 2020 Nov 16 Not indexed in PubMed https://www.biorxiv.org/content/10.1101/2020.11.15.383323v1.full.pdf - Breton G, Mendoza P, Hagglof,T et al Persistent Cellular Immunity to SARS-CoV-2 Infection. bioRxiv. 2020 Dec 9 https://www.biorxiv.org/content/10.1101/2020.12.08.416636v1 - Turner JS, Kim W, Kalaidina E et al. SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans. Nature 2021. May 24 PMID: 34030176 https://www.nature.com/articles/s41586-021-03647-4 - Callaway E Had COVID? You'll probably make antibodies for a lifetime. Nature News. 2021 May 26 correction May 27 https://www.nature.com/articles/d41586-021-01442-9 - Kaneko N, Kuo HH, Boucau J et al Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19. Cell. 2020 Oct 1;183(1):143-157.e13 PMID: 32877699 PMCID: PMC7437499 Free PMC article. - Ellebedy A et al SARS-CoV-2 mRNA vaccines induce a robust germinal centre reaction in humans. Nature Portfolio. In Review. Research Square. Posted March 10, 2021 https://www.researchsquare.com/article/rs-310773/v1 - Bollard C Call in the T-Cell Cavalry to Fight COVID in the Immunocompromised. Preliminary research suggests immunotherapy could play role in protecting vaccine non-responders. MedPage Today. July 29, 2021 https://www.medpagetoday.com/opinion/second-opinions/93805
  261. Cyranoski D Why Children Avoid the Worst Coronavirus Complications Might Lie in Their Arteries. Nature 2020 Jun;582(7812):324-325 PMID: 32546867 https://www.nature.com/articles/d41586-020-01692-z - Varga Z, Flammer AJ, Steiger P et al Endothelial cell infection and endotheliitis in COVID-19. Lancet. 2020 May 2;395(10234):1417-1418. PMID: 32325026 Free PMC article
  262. Mallapaty S How deadly is the coronavirus? Scientists are close to an answer? Public-health researchers use the infection fatality rate to gauge how to respond to a new disease, but it's tricky to calculate. Nature NEWS 16 June 2020 https://www.nature.com/articles/d41586-020-01738-2 - Verity R, Okell LC, Dorigatti I, et al. Estimates of the severity of coronavirus disease 2019: a model-based analysis Lancet Infect Dis. 2020;20(6):669-677. PMID: 32240634 Free PMC article - Russell TW, Hellewell J, Jarvis CI et al Estimating the infection and case fatality ratio for coronavirus disease (COVID-19) using age-adjusted data from the outbreak on the Diamond Princess cruise ship, February 2020 . Euro Surveill. 2020;25(12):pii=2000256. https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2020.25.12.2000256 - Streeck H, Schulte B, Kuemmerer B et L Infection fatality rate of SARS-CoV-2 infection in a German Community with a super-spreading event. medRxiv. June 2, 2020 https://www.medrxiv.org/content/10.1101/2020.05.04.20090076v2 - Blackburn J et al Infection Fatality Ratios for COVID-19 Among Noninstitutionalized Persons 12 and Older: Results of a Random-Sample Prevalence Study. Ann Intern Med. Sept 2, 2020 PMID: 32877214 https://www.acpjournals.org/doi/10.7326/M20-5352
  263. Matschke J et al. Neuropathology of patients with COVID-19 in Germany: A post-mortem case series. Lancet Neurol 2020 Nov 1; 19:919. PMID: 33031735 PMCID: PMC7535629 Free PMC article https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(20)30308-2/fulltext
  264. Wilson FP COVID-19 Risk Linked to Blood Type? Medscape - Jun 16, 2020 https://www.medscape.com/viewarticle/932333 - Ellinghaus D, Degenhardt F, Bujanda L et al Genomewide Association Study of Severe Covid-19 with Respiratory Failure N Eng J Med June 17, 2020 PMID: 32558485 https://www.nejm.org/doi/full/10.1056/NEJMoa2020283 - Reuters Staff More Evidence for Lower Risk With Certain Blood Groups Medscape - Dec 28, 2020. https://www.medscape.com/viewarticle/943243 - Ray JG, Schull MJ, Vermeulen MJ, Park AL Association Between ABO and Rh Blood Groups and SARS-CoV-2 Infection or Severe COVID-19 Illness. A Population-Based Cohort Study Ann Intern Med. 2020 Nov 24:M20-4511 PMID: 33226859 Free PMC article. https://www.acpjournals.org/doi/10.7326/M20-4511 - Wu SC, Arthur CM, Wang J et al The SARS-CoV-2 receptor-binding domain preferentially recognizes blood group A. Blood Adv (2021) 5 (5): 1305-1309 March 3 PMID: 33656534 PMCID: PMC7929867 Free PMC article https://ashpublications.org/bloodadvances/article/5/5/1305/475250/The-SARS-CoV-2-receptor-binding-domain
  265. Roubinian NH et al. Incidence of 30-day venous thromboembolism in adults tested for SARS-CoV-2 infection in an integrated health care system in northern California. JAMA Intern Med 2021 Apr 5; [e-pub]. PMID: 33818615 https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2778371
  266. Frontera JA et al. A prospective study of neurologic disorders in hospitalized COVID-19 patients in New York City. Neurology 2020 Oct 5; [e-pub]. PMID: 33020166 https://n.neurology.org/content/early/2020/10/05/WNL.0000000000010979
  267. Shi Z, de Vries HJ, Vlaar APJ et al Diaphragm Pathology in Critically Ill Patients With COVID-19 and Postmortem Findings From 3 Medical Centers. JAMA Intern Med. Published online November 16, 2020. PMID: 33196760 PMCID: PMC7670391 Free PMC article https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2773060
  268. Long QX, Tang XJ, Shi QL et al Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections. Nature Medicine, Published Online June 18, 2020 PMID: 32555424 https://www.nature.com/articles/s41591-020-0965-6.pdf
  269. Syrek R. Trending Clinical Topic: Thyroid and COVID-19 Medscape - Apr 02, 2021. https://reference.medscape.com/viewarticle/948197 - Tucker ME COVID-19 Can Cause Atypical Thyroid Inflammation. Medscape - Mar 21, 2021 https://www.medscape.com/viewarticle/947824
  270. Piazza G, Morrow DA Diagnosis, Management, and Pathophysiology of Arterial and Venous Thrombosis in COVID-19. JAMA. Published online November 23, 2020 PMID: 33226423 https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2020.23422
  271. Bhatla A, Mayer MM, Adusumalli S et al COVID-19 and Cardiac Arrhythmias. HeartRhythm. June 22, 2020 PMID: 32585191 https://www.heartrhythmjournal.com/article/S1547-5271(20)30594-4/fulltext
  272. King JA et al Symptoms associated with a positive result for a swab for SARS-CoV-2 infection among children in Alberta. CMAJ November 24, 2020 PMID: 33234533 https://www.cmaj.ca/content/early/2020/11/23/cmaj.202065
  273. Tucker ME Blood Glucose on Admission Predicts COVID-19 Severity in All. Medscape - Nov 30, 2020 https://www.medscape.com/viewarticle/941716 - Carrasco-Sanchez FJ et al Admission hyperglycaemia as a predictor of mortality in patients hospitalized with COVID-19 regardless of diabetes status: data from the Spanish SEMI-COVID-19 Registry. Annals of Medicine 2021 53(1) PMID: 33063540 PMCID: PMC7651248 Free PMC article https://www.tandfonline.com/doi/abs/10.1080/07853890.2020.1836566
  274. Bharat A, Querrey M, Markov NS et al Lung transplantation for patients with severe COVID-19. Sci Transl Med. 2020 Nov 30:eabe4282. PMID: 33257409 https://stm.sciencemag.org/content/early/2020/11/25/scitranslmed.abe4282 - Walter K Lung Transplants for COVID-19 - The Option of Last Resort. JAMA. Published online June 17, 2021 PMID: 34137786 https://jamanetwork.com/journals/jama/fullarticle/2781358
  275. Oxford University Risk of rare blood clotting higher for COVID-19 than for vaccines. News Release. April 15, 2021 https://www.ox.ac.uk/news/2021-04-15-risk-rare-blood-clotting-higher-covid-19-vaccines - Taquet M, Husain M, Geddes JR et al Cerebral venous thrombosis: a retrospective cohort study of 513,284 confirmed COVID-19 cases and a comparison with 489,871 people receiving a COVID-19 mRNA vaccine. Oxford University. 2021. April (unpublisged manuscript) https://osf.io/a9jdq/
  276. George J COVID Stroke Rare in ICU. Ischemic stroke in intensive care didn't raise mortality, but hemorrhagic stroke did. MedPage Today April 15, 2021 https://www.medpagetoday.com/meetingcoverage/aan/92116 - Fanning J, et al Stroke complicating critically ill patients with SARS-CoV-2: Analysis of the COVID-19 Critical Care Consortium (CCCC) international, multicenter observational study. American Academy of Neurology (AAN) 2021
  277. Keddie S, Pakpoor J, Mousele C et al Epidemiological and cohort study finds no association between COVID-19 and Guillain-Barre syndrome. Brain 2020. Dec 14 PMID: 33313649 https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awaa433/6031905
  278. Centers for Disease Control & Prevention (CDC) CDC updates, expands list of people at risk of severe COVID-19 illness. CDC Press Release. June 25, 2020 https://www.cdc.gov/media/releases/2020/p0625-update-expands-covid-19.html - Coronavirus Disease 2019 (COVID-19). People Who Need Extra Precautions People of Any Age with Underlying Medical Conditions Summary of Recent Changes. Revisions were made on June 25, 2020 https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/people-with-medical-conditions.html - Anderson MR et al. Body mass index and risk for intubation or death in SARS-CoV-2 infection. Ann Intern Med 2020 Jul 29; [e-pub]. PMID: 32726151 PMCID: PMC7397550 Free PMC article https://www.acpjournals.org/doi/10.7326/M20-3214 - Tartof SY et al. Obesity and mortality among patients diagnosed with COVID-19: Results from an integrated health care organization. Ann Intern Med 2020 Aug 12; [e-pub]. PMID: 32783686 Free PMC article. https://www.acpjournals.org/doi/10.7326/M20-3742 - Kass DA. COVID-19 and severe obesity: A big problem? Ann Intern Med 2020 Aug 12; [e-pub] PMID: 32783685 Free PMC article https://www.acpjournals.org/doi/10.7326/M20-5677
  279. Ingram I Cancer Immunotherapy Tied to Severe COVID-19 Outcomes - Nearly threefold increased risk of hospitalization, severe respiratory illness. MedPage Today June 25, 2020 https://www.medpagetoday.com/infectiousdisease/covid19/87263
  280. Roca-Gines J, Torres-Navarro I, Sanchez-Arraez K et al Assessment of Acute Acral Lesions in a Case Series of Children and Adolescents During the COVID-19 Pandemic. JAMA Dermatol. Published online June 25, 2020. PMID: 32584397 https://jamanetwork.com/journals/jamadermatology/fullarticle/2767773 - Herman A, Peeters C, Verroken V et al Evaluation of Chilblains as a Manifestation of the COVID-19 Pandemic. JAMA Dermatol. Published online June 25, 2020. PMID: 32584377 https://jamanetwork.com/journals/jamadermatology/fullarticle/2767774
  281. George J New-Onset Brain Complications in Hospitalized COVID-19 Patients - Altered mental states more common in young patients than expected MedPage Today June 25, 2020 https://www.medpagetoday.com/infectiousdisease/covid19/87273 - Varatharaj A, et al Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study. Lancet Psychiatry. June 25 2020 PMID: 32593341 Free PMC article https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(20)30287-X/fulltext - Merkler AE, Parikh NS, Mir S et al Risk of Ischemic Stroke in Patients With Coronavirus Disease 2019 (COVID-19) vs Patients With Influenza. JAMA Neurol. Published online July 2, 2020. PMID: 32511527 Free PMC article. https://jamanetwork.com/journals/jamaneurology/fullarticle/2768098
  282. Smith C Another coronavirus mutation was discovered - and this one might be more dangerous. BGR. Dec 19, 2020 https://www.msn.com/en-us/health/medical/another-coronavirus-mutation-was-discovered-%e2%80%93-and-this-one-might-be-more-dangerous/ar-BB1c4hoW - Reuters Staff South Africa identifies new coronavirus strain causing surge in cases. Reuters Health & Pharma. Dec 18, 2020 https://www.reuters.com/article/us-health-coronavirus-safrica/south-africa-identifies-new-coronavirus-strain-causing-surge-in-cases-idUSKBN28S2HH - Liu M, Stobbe M Virus Variant From South Africa Detected in US for First Time. Medscape - Jan 28, 2021 https://www.medscape.com/viewarticle/944867 - World Health Organization (WHO) New COVID-19 variants fuelling Africa's second wave. WHO News Release. Jan 28, 2021 https://www.afro.who.int/news/new-covid-19-variants-fuelling-africas-second-wave - Money L First infections with South Africa coronavirus strain found in California. Los Angeles Times. Feb 10, 2021 https://www.latimes.com/california/story/2021-02-10/first-cases-of-south-african-coronavirus-strain-found-in-california - Mwenda M, Saasa N, Sinyange N, et al. Detection of B.1.351 SARS-CoV-2 Variant Strain - Zambia, December 2020. MMWR Morb Mortal Wkly Rep. ePub: 17 February 2021 PMID: 33630820 Free article https://www.cdc.gov/mmwr/volumes/70/wr/mm7008e2.htm
  283. Louapre C, Collongues N, Stankoff B et al Clinical Characteristics and Outcomes in Patients With Coronavirus Disease 2019 and Multiple Sclerosis. JAMA Neurol. Published online June 26, 2020 PMID: 32589189 https://jamanetwork.com/journals/jamaneurology/fullarticle/2767776
  284. Harding A Dyspnea Most Important End-of-Life Symptom in COVID-19 Patients. Medscape - Jun 19, 2020. https://www.medscape.com/viewarticle/932660
  285. Greb E Headache May Predict Clinical Evolution of COVID-19 Medscape - Jun 19, 2020 https://www.medscape.com/viewarticle/932637
  286. Madia F, Merico B, Primiano G et al Acute myopathic quadriplegia in COVID-19 patients in the intensive care unit. Neurology. Jun 28, 2020 PMID: 32601119 https://n.neurology.org/content/early/2020/06/29/WNL.0000000000010280
  287. Ren Z, Wang H, Cui G et al Alterations in the human oral and gut microbiomes and lipidomics in COVID-19. Gut. 2021. March PMID: 33789966 Free PMC article. https://gut.bmj.com/content/early/2021/04/08/gutjnl-2020-323826
  288. Casagrande M, Fitzek A, Spitzer MS et al Presence of SARS-CoV-2 RNA in the Cornea of Viremic Patients With COVID-19. JAMA Ophthalmol. 2021;139(4):383-388 PMID: 33475692 PMCID: PMC7821081 (available on 2022-01-21) https://jamanetwork.com/journals/jamaophthalmology/fullarticle/2775161
  289. Brooks M COVID-19 Prolongs QT Interval Independent of Other Factors Medscape - Apr 26, 2021. https://www.medscape.com/viewarticle/949953 - Rubin GA, Desai AD, Chai Z et al Cardiac Corrected QT Interval Changes Among Patients Treated for COVID-19 Infection During the Early Phase of the Pandemic. JAMA Netw Open. 2021;4(4):e216842 PMID: 33890991 Free article https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2779053 - Etheridge SP, Asaki SY. COVID-19 Infection and Corrected QT Interval Prolongation - Collateral Damage From Our Newest Enemy. JAMA Netw Open. 2021;4(4):e217192 PMID: 33890995 Free article https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2779057
  290. Thakur KT, Miller EH, Glendinning MD et al COVID-19 neuropathology at Columbia University Irving Medical Center/ New York Presbyterian Hospital. Brain, Published: 15 April 2021 PMID: 33856027 https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awab148/6226391
  291. Norman M, Naver L, Soderling J Association of Maternal SARS-CoV-2 Infection in Pregnancy With Neonatal Outcomes. JAMA. Published online April 29, 2021 PMID: 33914014 https://jamanetwork.com/journals/jama/fullarticle/2779586 - Dumitriu D, Gyamfi-Bannerman C. Understanding Risk for Newborns Born to SARS-CoV-2-Positive Mothers JAMA. Published online April 29, 2021. PMID: 33914045 https://jamanetwork.com/journals/jama/fullarticle/2779587
  292. Gao M, Piernas C, Astbury NM et al Associations between body-mass index and COVID-19 severity in 6.9 million people in England: a prospective, community-based, cohort study. Lancet Diabetes & Endocrinol 2021. April 28. PMID: 33932335 PMCID: PMC8081400 Free PMC article https://www.thelancet.com/journals/landia/article/PIIS2213-8587(21)00089-9/fulltext
  293. Chou SHY, Beghi E, Helbok R et al Global Incidence of Neurological Manifestations Among Patients Hospitalized With COVID-19 - A Report for the GCS-NeuroCOVID Consortium and the ENERGY Consortium. JAMA Netw Open. 2021;4(5):e2112131. May 11. PMID: 33974053 PMCID: PMC8114143 Free PMC article https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2779759
  294. Zoler ML Half of Patients in Hospital for COVID-19 Get Acute Kidney Injury Medscape - Apr 27, 2021 https://www.medscape.com/viewarticle/950008
  295. Barham HP, Taha MA, Broyles ST et al Association Between Bitter Taste Receptor Phenotype and Clinical Outcomes Among Patients With COVID-19. JAMA Netw Open. 2021;4(5):e2111410. May 25 PMID: 34032852 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2780134 - Bartlett AH Seeking clues to mysteries of coronavirus by studying a person's ability to taste bitterness. Washington Post. June 12, 2021 https://www.washingtonpost.com/health/research-coronavirus-taste-predict-covid-severity/2021/06/11/635a366e-c7b1-11eb-81b1-34796c7393af_story.html
  296. Aschman T, Schneider J, Greuel S et al Association Between SARS-CoV-2 Infection and Immune-Mediated Myopathy in Patients Who Have Died. JAMA Neurol. Published online June 11, 2021. PMID: 34115106 https://jamanetwork.com/journals/jamaneurology/fullarticle/2781013
  297. Stephenson J CDC Estimates Thousands of Excess Deaths Among US Patients with End-Stage Renal Disease During COVID-19 Pandemic's Early Months. JAMA Health Forum. 2021;2(6):e211835. June 8 Not indexed in PubMed https://jamanetwork.com/journals/jama-health-forum/fullarticle/2781027
  298. Kompaniyets L, Agathis NT, Nelson JM et al Underlying Medical Conditions Associated With Severe COVID-19 Illness Among Children. JAMA Netw Open. 2021;4(6):e2111182 PMID: 34097050 PMCID: PMC8185607 Free PMC article https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2780706 - Schuster JE, de St Maurice A COVID-19 in Children - Not Just Little Adults. JAMA Netw Open. 2021;4(6):e2111441 PMID: 34097052 Free article https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2780708
  299. Abbasi J Study Suggests Lasting Immunity After COVID-19, With a Big Boost From Vaccination. JAMA. Published online July 14, 2021 https://jamanetwork.com/journals/jama/fullarticle/2782139
  300. Kofman A, Kantor R, Adashi EY. Potential COVID-19 Endgame ScenariosEradication, Elimination, Cohabitation, or Conflagration? JAMA. 2021;326(4):303-304 PMID: 34236382 https://jamanetwork.com/journals/jama/fullarticle/2781945
  301. Nature Briefing. July 28, 2021 briefing@nature.com - Scudellari M How the coronavirus infects cells - and why Delta is so dangerous Nature. News Feature. July 28, 2021 https://www.nature.com/articles/d41586-021-02039-y
  302. Yang AC, Fern F, Losada PM et al. Dysregulation of brain and choroid plexus cell types in severe COVID-19. Nature 2021 Jul; 595:565. PMID: 34153974 https://www.nature.com/articles/s41586-021-03710-0 - Marshall M. COVID and the brain: Researchers zero in on how damage occurs. Nature 2021 Jul; 595:484 PMID: 34234323 https://www.nature.com/articles/d41586-021-01693-6
  303. Clift AK, Saatci D, Coupland CAC et al. Sickle cell disorders and severe COVID-19 outcomes: A cohort study. Ann Intern Med 2021 Jul 20; [e-pub]. PMID: 34338553 PMCID: PMC8343340 Free PMC article https://www.acpjournals.org/doi/10.7326/M21-1375
  304. Harris S Ryan Ungaro, MD, MS, on Risk of Severe COVID-19 In People With Autoimmune and Chronic Inflammatory Diseases - Systemic corticosteroids, not the immune-mediated diseases, linked with worse COVID outcomes. MedPage Today August 20, 2021 https://www.medpagetoday.com/reading-room/acrr/psoriaticarthritis/94130
  305. Kwon D Rogue antibodies involved in almost one-fifth of COVID deaths. Nature News. August 31, 2021 https://www.nature.com/articles/d41586-021-02337-5 - Bastard P, Gervais A, Le Voyer T et al Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths, Sci Immunol. 2021 Aug 19;6(62):eabl4340. PMID: 34413139
  306. Kachadourian LK, Feder A, Murrough JW et al. Transdiagnostic psychiatric symptoms, burnout, and functioning in frontline health care workers responding to the COVID-19 pandemic: A symptomics analysis. J Clin Psychiatry 2021 Apr 27; 82:20m13766. PMID: 34004095 https://www.psychiatrist.com/jcp/covid-19/transdiagnostic-psychiatric-symptoms-burnout-functioning-frontline-health-care-workers-responding-to-covid-19/
  307. Dumitrascu F, Branje KE, Hladkowicz ES et al Association of frailty with outcomes in individuals with COVID-19: A living review and meta-analysis. J Am Geriatr Soc 69(9):2419-2429 PMID: 34048599 PMCID: PMC8242611 Free PMC article https://agsjournals.onlinelibrary.wiley.com/doi/full/10.1111/jgs.17299
  308. Luijten LWG, Leonhard SE, van der Eijk AA et al Guillain-Barre syndrome after SARS-CoV-2 infection in an international prospective cohort study. Brain. 2021 September 23 PMID: 34553216 https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awab279/6373760
  309. Locke T COVID-19 Hospitalisation '80% More Likely for Smokers' Medscape. September 28, 2021 https://www.medscape.com/viewarticle/959835
  310. Wilson FP The Seven Symptoms That Best Predict COVID. Medscape. September 28, 2021 https://www.medscape.com/viewarticle/959782
  311. Abassi J The Flawed Science of Antibody Testing for SARS-CoV-2 Immunity. JAMA. Published online October 21, 2021 PMID: 34673883 https://jamanetwork.com/journals/jama/fullarticle/2785530
  312. Kuehn BM Aspergillosis Is Common Among COVID-19 Patients in the ICU. JAMA. 2021;326(16):1573 PMID: 34698776 https://jamanetwork.com/journals/jama/fullarticle/2785489
  313. Pickens CO, Gao CA, Cutica MJ et al. Bacterial superinfection pneumonia in patients mechanically ventilated for COVID-19 pneumonia. Am J Respir Crit Care Med 2021 Oct 15; 204:921. PMID: 34409924 PMCID: PMC8534629 Free PMC article https://www.atsjournals.org/doi/10.1164/rccm.202106-1354OC
  314. Kozlov M How do people resist COVID infections? Hospital workers offer a hint. Nature News. Nov 11, 2021 https://www.nature.com/articles/d41586-021-03110-4 - Swadling L, Diniz MO, Schmidt NM et al. Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2. Nature. 2021. PMID: 34758478
  315. Crist C Coronavirus Attacks Fat Tissue, Study Says. Medscape. December 09, 2021 https://www.medscape.com/viewarticle/964500 - Martinez-Colon GJ, Ratnasiri, Heping Chen et al SARS-CoV-2 infects human adipose tissue and elicits an inflammatory response consistent with severe COVID-19. bioRxiv 2021. Oct 25, 2021 https://www.biorxiv.org/content/10.1101/2021.10.24.465626v
  316. Villar J, Ariff S, Gunier RB et al Maternal and Neonatal Morbidity and Mortality Among Pregnant Women With and Without COVID-19 Infection. The INTERCOVID Multinational Cohort Study. JAMA Pediatr. 2021;175(8):817-826. PMID: 33885740 PMCID: PMC8063132 Free PMC article https://jamanetwork.com/journals/jamapediatrics/fullarticle/2779182
  317. Schmidt AL, Tucker MD, Bakouny Z et al. Association between androgen deprivation therapy and mortality among patients with prostate cancer and COVID-19. JAMA Netw Open 2021 Nov 12; 4:e2134330. PMID: 34767021 PMCID: PMC8590166 Free PMC article https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2786026
  318. Downes DJ, Cross AR, Hua P et al Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus. Nature Genetics 2021, 53:1606-1615. Nov 4. PMID: 34737427 PMCID: PMC7611960 (available on 2022-05-04) https://www.nature.com/articles/s41588-021-00955-3
  319. Aminian A, Tu C, Milinovich A et al. Association of weight loss achieved through metabolic surgery with risk and severity of COVID-19 infection. JAMA Surg 2021 Dec 29; [e-pub]. PMID: 34964827 PMCID: PMC8717211 (available on 2022-12-29) https://jamanetwork.com/journals/jamasurgery/fullarticle/2787613
  320. Grant K COVID in Kids Under 5 May Look Like Croup, Pediatricians Warn. Barking cough may be specific to Omicron. MedPage Today January 13, 2022 https://www.medpagetoday.com/special-reports/exclusives/96654
  321. Metz TD, Clifton RG, Hughes BL et al Association of SARS-CoV-2 Infection With Serious Maternal Morbidity and Mortality From Obstetric Complications. JAMA. Published online February 7, 2022. PMID: 35129581 https://jamanetwork.com/journals/jama/fullarticle/2788985 - Smith ER, Oakley E, Grandner GW et al Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection: an individual participant data meta-analysis. BMJ Glob Health. 2023. 8(1) PMID: 36646475 https://gh.bmj.com/content/8/1/e009495
  322. Crist C Study: Vitamin D Deficiency Linked to Severe COVID. Medscape. February 08, 2022 https://www.medscape.com/viewarticle/968121 - Dorr AA, Morozov N, Daoud A et al Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness. PLOS One. 2022. Feb 3. https://doi.org/10.1371/journal.pone.0263069 - Pal R, Banerjee M, Bhadada SK et al. Vitamin D supplementation and clinical outcomes in COVID-19: a systematic review and meta-analysis. J Endocrinol Invest 2021. June 24 PMID: 34165766 PMCID: PMC8223190 Free PMC article https://link.springer.com/article/10.1007/s40618-021-01614-4
  323. Anderson P Stroke Risk Highest Right After COVID Infection. Medscape. Feb 15, 2022 https://www.medscape.com/viewarticle/968576
  324. Deng JZ, Chan J, Potter A et al. The risk of postoperative complications after major elective surgery in active or resolved COVID-19 in the United States. Ann Surg 2022 Feb; 275:242 PMID: 34793348 PMCID: PMC8745943 Free PMC article https://journals.lww.com/annalsofsurgery/Fulltext/2022/02000/The_Risk_of_Postoperative_Complications_After.7.aspx
  325. Blankenship J Severe COVID-19 Increases Risk for Peripheral Nerve Damage. Medscape. Feb 23, 2022 https://www.medscape.com/viewarticle/969019 - Franz CK, Murthy NK, Malik GR et al Acquired peripheral nerve injuries associated with severe COVID-19. medRxiv. February 07, 2022. https://www.medrxiv.org/content/10.1101/2021.09.24.21263996v2
  326. Wendling P Even Moderate Exercise Offers Strong Shield From COVID-19. Medscape. March 25, 2022 https://www.medscape.com/viewarticle/970981 - Steenkamp L,Saggers RT, Bandini R et al Small steps, strong shield: directly measured, moderate physical activity in 65,361 adults is associated with significant protective effects from severe COVID-19 outcomes. Br J Sports Med. 2022 Feb 9:bjsports-2021-105159 PMID: 35140062 PMCID: PMC8844956 Free PMC article https://bjsm.bmj.com/content/early/2022/02/08/bjsports-2021-105159
  327. Matthews S Mortality Comparison of COVID-19, Influenza Among Hospitalized Older Adults. Annals of Long-Term Care. April 28, 2022 https://www.hmpgloballearningnetwork.com/site/altc/news/mortality-comparison-covid-19-influenza-among-hospitalized-older-adults - Seligman B, Charest B, Ho YL et al. 30-day mortality following COVID-19 and influenza hospitalization among US veterans aged 65 and older. J Am Geriatr Soc. 2022. April 26. PMID: 35474510
  328. Monaco K COVID Was Third Leading Cause of U.S. Deaths in 2021, Says CDC. But agency sees racial disparities shrink versus 2020. MedPage Today April 22, 2022 https://www.medpagetoday.com/infectiousdisease/covid19/98375 - Truman BI, Chang M, Moonesinghe R. Provisional COVID-19 Age-Adjusted Death Rates, by Race and Ethnicity - United States, 2020-2021. MMWR Morb Mortal Wkly Rep. ePub: 22 April 2022 https://www.cdc.gov/mmwr/volumes/71/wr/mm7117e2.htm
  329. Katsoularis I et al. Risks of deep vein thrombosis, pulmonary embolism, and bleeding after covid-19: Nationwide self-controlled cases series and matched cohort study. BMJ 2022 Apr 6; 377:e069590 PMID: 35387772 PMCID: PMC8984137 Free PMC article
  330. Rutkai I et al. Neuropathology and virus in brain of SARS-CoV-2 infected non-human primates. Nat Commun 2022 Apr 1; 13:1745. PMID: 35365631 PMCID: PMC8975902 Free PMC article https://www.nature.com/articles/s41467-022-29440-z
  331. Vijayakumar B et al. CT lung abnormalities after COVID-19 at 3 months and 1 year after hospital discharge. Radiology 2022 May; 303:444-454 PMID: 34609195 PMCID: PMC8515207 Free PMC article https://pubs.rsna.org/doi/10.1148/radiol.2021211746
  332. Lee MH, Perl DP, Steiner J et al Neurovascular injury with complement activation and inflammation in COVID-19. Brain. 2022. July 5. PMID: 35788639 https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awac151/6621999
  333. Calder R New COVID subvariant could make you sweat at night. New York Times. July 9, 2022 https://nypost.com/2022/07/09/new-covid-subvariant-could-make-you-sweat-at-night/
  334. Lou N Blood Viscosity Enters the Equation in COVID Mortality. Its association with death may be unrelated to inflammation. MedPage Today July 18, 2022 https://www.medpagetoday.com/infectiousdisease/covid19/99776 - Choi D, Waksman O, Shaik A et al Association of Blood Viscosity With Mortality Among Patients Hospitalized With COVID-19. J Am Coll Cardiol 2022 80(4):316-328 July PMID: 35863848 https://www.jacc.org/doi/10.1016/j.jacc.2022.04.060
  335. Ellis R Sore Throat, Cough Now Top COVID Symptoms: UK Study. Medscape. July 15, 2022 https://www.medscape.com/viewarticle/977322
  336. Croft J Most People With Omicron Don't Know They're Infected. Medscape. August 19, 2022 https://www.medscape.com/viewarticle/979471 - Joung SY, Ebinger JE, Sun N et al Awareness of SARS-CoV-2 Omicron Variant Infection Among Adults With Recent COVID-19 Seropositivity. JAMA Netw Open. 2022;5(8):e2227241 PMID: 35976645 Free article https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2795246
  337. Xie J, Prats-Uribe A, Feng Q et al. Clinical and genetic risk factors for acute incident venous thromboembolism in ambulatory patients with COVID-19. JAMA Intern Med 2022 Aug 18; [e-pub] PMID: 35980616 PMCID: PMC9389434 Free PMC article https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2795466
  338. Crist C Sore Throat Becoming Dominant COVID Symptom: Reports. Medscape. Oct 4, 2022 https://www.medscape.com/viewarticle/981849
  339. Craven J Headache May Predict Better Survival for Inpatients With COVID-19. Medscape. Oct 13, 2022 https://www.medscape.com/viewarticle/982437 - Gallardo VJ, Shapiro RE, Caronna E, Pozo-Rosich P. The relationship of headache as a symptom to COVID-19 survival: A systematic review and meta-analysis of survival of 43,169 inpatients with COVID-19. Headache. 2022 Sep;62(8):1019-1028 PMID: 36053077 PMCID: PMC9539239 Free PMC article https://headachejournal.onlinelibrary.wiley.com/doi/10.1111/head.14376
  340. Smith DM, Li JZ, Moser C et al Recurrence of Symptoms Following a 2-Day Symptom Free Period in Patients With COVID-19. JAMA Netw Open. 2022;5(10):e2238867. PMID: 36301549 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2797789
  341. Raisi-Estabragh Z et al. Cardiovascular disease and mortality sequelae of COVID-19 in the UK Biobank. Heart 2022 Oct 24; [e-pub] PMID: 36280346 https://heart.bmj.com/content/early/2022/09/21/heartjnl-2022-321492
  342. Jara-Palomares L et al. Rate of recurrence after discontinuing anticoagulation therapy in patients with COVID-19-associated venous thromboembolism. JAMA Intern Med 2022 Nov 7; [e-pub]. PMID: 36342711 https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2797777
  343. Bilinski A, Thompson K, Emanuel E. COVID-19 and Excess All-Cause Mortality in the US and 20 Comparison Countries, June 2021-March 2022. JAMA. Published online November 18, 2022. PMID: 36399335 https://jamanetwork.com/journals/jama/fullarticle/2798990
  344. Abrams Z New drug shows promise for fighting both COVID-19 and cancer. Keck School of Medicine USC. Keck School News. Nov 14, 2022 https://keck.usc.edu/new-drug-shows-promise-for-fighting-both-covid-19-and-cancer/ - Shin WJ, Ha DP, Machida K, Lee AS The stress-inducible ER chaperone GRP78/BiP is upregulated during SARS-CoV-2 infection and acts as a pro-viral protein. Nature Communications. 2022. 13:6551. Nov 14 PMID: 36376289 PMCID: PMC9663498 Free PMC article. https://www.nature.com/articles/s41467-022-34065-3
  345. Rapid Review Quiz: Hospital-Acquired Pneumonia Medscape. Sept 15, 2022 https://reference.medscape.com/viewarticle/980567
  346. Mavrikaki M, Lee JD, Solomon IH, Slack FJ. Severe COVID-19 induces molecular signatures of aging in the human brain. medRxiv. 2021 Nov 24:2021.11.24.21266779. Preprint. PMID: 34845457 Free PMC article. - Mavrikaki M et al. Severe COVID-19 is associated with molecular signatures of aging in the human brain. Nat Aging 2022 Dec 5; [e-pub] Not indexed in PubMed https://www.nature.com/articles/s43587-022-00321-w
  347. Stein SR, Ramelli SC, Grazoli A et al SARS-CoV-2 infection and persistence in the human body and brain at autopsy. Nature 2022. 612:758-763. Dec 14 PMID: 36517603 PMCID: PMC9749650 Free PMC article https://www.nature.com/articles/s41586-022-05542-y
  348. Young DR, Sallis JF, Baecker A et al Associations of Physical Inactivity and COVID-19 Outcomes Among Subgroups. Am J Preventitive Med. Dec 14, 2022 https://www.ajpmonline.org/article/S0749-3797%2822%2900526-8/fulltext
  349. Kwan AC, Ebinger JE, Botting P et al Association of COVID-19 Vaccination With Risk for Incident Diabetes After COVID-19 Infection. JAMA Netw Open. 2023;6(2):e2255965. PMID: 36787145 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2801415
  350. Deo R et al. Symptom and viral rebound in untreated SARS-CoV-2 infection. Ann Intern Med 2023 Feb 21; [e-pub]. PMID: 36802755 https://www.acpjournals.org/doi/10.7326/M22-2381
  351. Xie Y, Choi T, Al-Aly Z. Risk of Death in Patients Hospitalized for COVID-19 vs Seasonal Influenza in Fall-Winter 2022-2023. JAMA. Published online April 6, 2023 PMID: 37022720 https://jamanetwork.com/journals/jama/fullarticle/2803749
  352. Wu SC et al Blood Group A Enhances SARS-CoV-2 Infection. Blood. 2023 Jun 27:blood.2022018903. PMID: 37367252 PMCID: PMC10294591 Free PMC article https://ashpublications.org/blood/article/doi/10.1182/blood.2022018903/496471/Blood-Group-A-Enhances-SARS-CoV-2-Infection
  353. Harris E Patients With COVID-19 and Fungal Infections Had High Mortality Rates. JAMA. 2023;330(3):210-211. PMID: 37379036 https://jamanetwork.com/journals/jama/fullarticle/2806853
  354. Chen R, Charpignon ML, Raquib RV et al Excess Mortality With Alzheimer Disease and Related Dementias as an Underlying or Contributing Cause During the COVID-19 Pandemic in the US. JAMA Neurol. Published online July 17, 2023 PMID: 37459088 PMCID: PMC10352932 Free PMC article https://jamanetwork.com/journals/jamaneurology/fullarticle/2806770
  355. Quinn KL, Stukel TA, Huang A et al. Comparison of medical and mental health sequelae following hospitalization for COVID-19, influenza, and sepsis. JAMA Intern Med 2023 Jun 20; [e-pub] PMID: 37338892 PMCID: PMC10282961 Free PMC article https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2806192
  356. Hughes S, Shelley A COVID Coronary Plaque Infection Confirms CV Risk. Medscape. Oct 23, 2023 https://www.medscape.com/viewarticle/997638 - Eberhardt N et al SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels. PMID: 37645908 PMCID: PMC10461985 Free PMC article
  357. Mahmoud MA, Ayoub HH, Coyle P, et al. SARS-CoV-2 infection and effects of age, sex, comorbidity, and vaccination among older individuals: A national cohort study. Influenza Other Respir Viruses. 2023 Nov;17(11):e13224. PMID: 38019700 PMCID: PMC10663173 Free PMC article https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663173/
  358. Ioannou GN, Berry K, Rajeevan N et al Effectiveness of Nirmatrelvir-Ritonavir Against the Development of Post-Covid-19 Conditions Among U.S. Veterans. A Target Trial Emulation. Ann Intern Med 2023 Nov;176(11):1486-1497 PMID: 37903369 PMCID: PMC10620954 Free PMC article https://acp-prod.literatumonline.com/doi/full/10.7326/M23-1394
  359. Fung KW, Baye F, Baik SH, McDonald CJ. Nirmatrelvir and Molnupiravir and Post-COVID-19 Condition in Older Patients. JAMA Intern Med. 2023 Dec 1;183(12):1404-1406 PMID: 37870856 PMCID: PMC10594174 Free PMC article https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2811092 - Harris V et al. Health outcomes 3 months and 6 months after molnupiravir treatment for COVID-19 for people at higher risk in the community (PANORAMIC): A randomised controlled trial. Lancet Infect Dis 2024 Sep 9; [e-pub]. PMID: 39265595 Free article https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00431-6/fulltext
  360. Smith DJ, Lambrou A, Patel P. SARS-CoV-2 Rebound With and Without Use of COVID-19 Oral Antivirals. MMWR Morb Mortal Wkly Rep. 2023 Dec 22;72(51):1357-1364. PMID: 38127665 PMCID: PMC10754268 Free PMC article. https://www.cdc.gov/mmwr/volumes/72/wr/mm7251a1.htm - Harrington PR, Cong J, Troy SB et al Evaluation of SARS-CoV-2 RNA Rebound After Nirmatrelvir/Ritonavir Treatment in Randomized, Double-Blind, Placebo-Controlled Trials - United States and International Sites, 2021-2022. MMWR Morb Mortal Wkly Rep. 2023 Dec 22;72(51):1365-1370. PMID: 38127674 PMCID: PMC10754264 Free PMC article. Clinical Trial. https://www.cdc.gov/mmwr/volumes/72/wr/mm7251a2.htm
  361. Smith-Jeffcoat SE et al. Symptoms, viral loads, and rebound among coronavirus disease 2019 (COVID-19) outpatients treated with nirmatrelvir/ritonavir compared with propensity score- matched untreated individuals. Clin Infect Dis 2023 Nov 14; [e-pub]. PMID: 37963102 https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciad696/7420299
  362. Edelstein GE et al. SARS-CoV-2 virologic rebound with nirmatrelvir-ritonavir therapy: An observational study. Ann Intern Med 2023 Nov 14; [e-pub]. PMID: 37956428 PMCID: PMC10644265 Free PMC article https://www.acpjournals.org/doi/10.7326/M23-1756 - Cohen MS, Brown ER. Rebound of COVID-19 with nirmatrelvir-ritonavir antiviral therapy. Ann Intern Med 2023 Nov 14; [e-pub]. PMID: 37956432 PMCID: PMC10644264 Free PMC article https://www.acpjournals.org/doi/10.7326/M23-2887
  363. Kim MS, Lee H, Lee SW et al Long-Term Autoimmune Inflammatory Rheumatic Outcomes of COVID-19. A Binational Cohort Study. Ann Intern Med. 2024. March 5. PMID: 38437702 https://www.acpjournals.org/doi/abs/10.7326/M23-1831
  364. Sartini M et al Preventive Vitamin D Supplementation and Risk for COVID-19 Infection: A Systematic Review and Meta-Analysis. Nutrients 2024 16(5):679 PMID: 38474807 PMCID: PMC10935157 Free PMC article https://www.mdpi.com/2072-6643/16/5/679
  365. Lindeboom RGH et al. Human SARS-CoV-2 challenge uncovers local and systemic response dynamics. Nature 2024 Jul; 631:189 PMID: 38898278 PMCID: PMC11222146 Free PC article https://www.nature.com/articles/s41586-024-07575-x - Israelow B, Iwasaki A. First encounter with SARS-CoV-2: Immune portraits of COVID susceptibility. Nature 2024 Jul; 631:33. PMID: 38898251 https://www.nature.com/articles/d41586-024-01644-x
  366. Wise J Covid-19: Progression to clinical type 1 diabetes accelerated after infection, study suggests. BMJ 2024;386:q1557 PMID: 39013567 https://www.bmj.com/content/386/bmj.q1557
  367. Taylor K, Eastwood S, Walker V, et al. Incidence of diabetes after SARS-CoV-2 infection in England and the implications of COVID-19 vaccination: a retrospective cohort study of 16 million people. Lancet Diabetes Endocrinol. 2024 Aug;12(8):558-568 PMID: 39054034 Free article https://www.thelancet.com/journals/landia/article/PIIS2213-8587(24)00159-1/fulltext
  368. Halim C, Howen M, Fitrisubroto AANB et al Relevance of Mediterranean diet as a nutritional strategy in diminishing COVID-19 risk: A systematic review PLoS One. 2024 Aug 21;19(8):e0301564. PMID: 39167591 PMCID: PMC11338465 Free PMC article. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0301564
  369. Preger A, Wei R, Berg B, Golomb BA. COVID-19-associated rhabdomyolysis: A scoping review. Int J Infect Dis. 2023 Nov;136:115-126. PMID: 37730012 Free article. Review. https://www.ijidonline.com/article/S1201-9712(23)00713-0/fulltext
  370. Hilser JR, Spencer NJ, Afshari K et al COVID-19 Is a Coronary Artery Disease Risk Equivalent and Exhibits a Genetic Interaction With ABO Blood Type. Arterioscler Thromb Vasc Biol. 2024 Oct 9. PMID: 39381876 https://www.ahajournals.org/doi/10.1161/ATVBAHA.124.321001
  371. Myers J, Kokkinos P, Cadenas-Sanchez C et al Impact of Cardiorespiratory Fitness on COVID-19-Related Outcomes: The Exercise Testing and Health Outcomes Study (ETHOS) Mayo Clin Proc. 2024 Sep 6:S0025-6196(24)00347-1. PMID: 39243247 https://www.mayoclinicproceedings.org/article/S0025-6196(24)00347-1/fulltext
  372. Novel Coronovirus (Covid-19) Medscape Coronavirus Resource Center https://www.medscape.com/resource/coronavirus
  373. Updated references - Coronavirus COVID-19 USA cases (Johns Hopkins) https://medpage.maps.arcgis.com/apps/opsdashboard/index.html#/c7dafaae988f4c07a13a9ede90e43a47 - MedPage Today. United States COVID-19 Coronavirus Case Tracker https://www.medpagetoday.com/infectiousdisease/covid19/85354 - Centers for Disease Control & Prevention (CDC) Strategies to Prevent the Spread of COVID-19 in Long-Term Care Facilities (LTCF) https://www.cdc.gov/coronavirus/2019-ncov/healthcare-facilities/prevent-spread-in-long-term-care-facilities.html - Centers for Disease Control & Prevention (CDC) Interim Guidance for Healthcare Facilities: Preparing for Community Transmission of COVID-19 in the United States. https://www.cdc.gov/coronavirus/2019-ncov/healthcare-facilities/guidance-hcf.html - Centers for Disease Control & Prevention (CDC) Preparing for COVID-19: Long-term Care Facilities, Nursing Homes https://www.cdc.gov/coronavirus/2019-ncov/healthcare-facilities/prevent-spread-in-long-term-care-facilities.html - Centers for Disease Control & Prevention (CDC) Information for Clinicians on Therapeutic Options for COVID-19 Patients. https://www.cdc.gov/coronavirus/2019-ncov/hcp/therapeutic-options.html - Centers for Disease Control and Prevention COVID-19 clinical care (interim guidance) https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-guidance-management-patients.html - Centers for Disease Control & Prevention (CDC) Implementing Safety Practices for Critical Infrastructure Workers Who May Have Had Exposure to a Person with Suspected or Confirmed COVID-19. https://www.cdc.gov/coronavirus/2019-ncov/community/critical-workers/implementing-safety-practices.html - Centers for Disease Control & Prevention (CDC) Symptoms of Coronavirus https://www.cdc.gov/coronavirus/2019-ncov/symptoms-testing/symptoms.html - Centers for Disease Control & Prevention (CDC) Symptom-Based Strategy to Discontinue Isolation for Persons with COVID-19 https://www.cdc.gov/coronavirus/2019-ncov/community/strategy-discontinue-isolation.html - World Health Organization Clinical Management Guidance (interim guidance) https://www.who.int/publications-detail/clinical-management-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected ,Interim Guidance - Mayo Clinic: Coronavirus disease 2019 (COVID-19) https://www.mayoclinic.org/diseases-conditions/coronavirus/symptoms-causes/syc-20479963 - Mayo Clinic Health System: COVID-19 (Coronavirus) https://www.mayoclinichealthsystem.org/covid19 - Clevelnad clinic: Coronavirus (COVID-19) https://my.clevelandclinic.org/landing/preparing-for-coronavirus - MedlinePlus: Coronavirus Disease 2019 (COVID-19) https://medlineplus.gov/coronavirus/ - Medical Board of California California Department of Public Health (CDPH), CDPH Provides Health Update and Interim Guidance for Health Care Providers Regarding 2019 Novel Coronavirus (nCoV). https://www.cdph.ca.gov/Programs/CHCQ/LCP/CDPH%20Document%20Library/AFL-20-10.pdf - N Eng L Med Coronavirus (Covid-19) https://www.nejm.org/coronavirus - JAMA Network Coronavirus Disease 2019 (COVID-19) https://jamanetwork.com/journals/jama/pages/coronavirus-alert - COVID-19 (2019 novel coronavirus) resource center for physicians https://www.ama-assn.org/delivering-care/public-health/covid-19-2019-novel-coronavirus-resource-center-physicians - Centers for Disease Control & Prevention (CDC) Interim Guidelines for COVID-19 Antibody Testing https://www.cdc.gov/coronavirus/2019-ncov/lab/resources/antibody-tests-guidelines.html