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cortisol/neomycin/polymixin-B (Corticosporin, Cortisporin, Cortomycin)
Topical agent
Ophthalmic agent: Tradename AK-spore HC.
Corticosporin otic.
Indications:
Ophthalmic
- inflammatory ocular condition
a) corticosteroid indicated
b) bacterial infection of risk of bacterial infection
Otic
1) treatment of superficial bacterial infection of the external auditory canal
2) associated inflammatory response
Contraindications:
1) Herpes simplex
2) Vaccinia
3) Varicella
pregnancy-category C
safety in lactation ?
Dosage:
Topical: Apply cream/ointment BID/TID.
Ophthalmic
- ointment or 1 drop suspension every 3-4 hours or BID-QID
Otic
- 4 drops TID-QID
Ointment: (ophthalmic)
- neomycin, polymixin B, hydrocortisone 1%
Suspension: (ophthalmic)
- neomycin, polymixin B, hydrocortisone 1% Solution (otic)
- neomycin sulfate 5 mg, polymixin B sulfate 10,000 units, hydrocortisone acetate 10 mg/mL (10 mL) Suspension (otic)
- neomycin sulfate 5 mg, polymixin B sulfate 10,000 units, hydrocortisone acetate 10 mg/mL (10 mL)
Cream: neomycin sulfate 5 mg, polymixin B sulfate 10,000 units, hydrocortisone acetate 5 mg/g (7.5 g)
Antimicrobial activity:
- Streptococcus
- Staphylococcus
- Anaerobic cocci
- Corynebacterium
- Clostridium
- Neisseria gonorrhoeae
- Neisseria meningitidis
- E. coli
- H. influenzae
- Klebsiella
- Moraxella lacunata
- Proteus
- Serratia
- Pseudomonas
- E. aerogenes
- Fusobacterium
- Actinomyces israelii
- Treponema pallidum
- Treponema vincenti
Adverse effects:
1) common (> 10%)
- hypersensitivity
2) less common (1-10%)
- contact dermatitis, erythema, rash, urticaria, burning, neuromuscular blockade, ototoxicity, nephrotoxicity, bladder irritation
3) other
a) itching
b) irritation
c) neomycin is a contact sensitizer [3]
d) apnea [3]
Ophthalmic
1) local irritation
2) increased intraocular pressure
3) glaucoma
General
antibiotic-glucocorticoid combination
References
- Department of Veterans Affairs, VA National Formulary
- Drug Information & Medication Formulary, Veterans Affairs,
Central California Health Care System, 1st ed., Ravnan et al
eds, 1998
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
Components
cortisol; hydrocortisone (Cortef, Solu-Cortef, Alphaderm, Cetacort, Cortenema, Nutracort)
neomycin (Mycifradin)
polymixin B (Aerosporin)