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cornus ammonis [CA]-3
Pole of the cornu ammonis that interlocks with the dentate gyrus.
Afferents:
1) other levels of CA3 (along rostral caudal axis)
2) mossy fibers from the dentate gyrus (hippocampal mossy fiber pathway)
3) entorhinal cortex (perforant pathway)
Efferents:
1) other levels of CA3 (along rostral caudal axis)
2) CA1 (Schaeffer collaterals)
3) subcortical (see hippocampal efferents, subcortical)
a) septal nuclei
b) anterior nucleus of thalamus
c) mammillary body
d) claustrum
e) amygdala
f) nucleus accumbens
g) striatum (caudate/putamen)
h) hypothalamus
Comparative biology:
- CA3 NMDA receptors required for associative memory recall in mice [2]
- in normal rats a functional gradient occurs in CA3 along the transverse axis, as pattern-separated outputs (proximal CA3) with transition to pattern- completed outputs (distal CA3)
- normal transition from pattern separation to pattern completion along the CA3 transverse axis is disrupted in aged memory-impaired rats [3]
Related
entorhinal cortex (Brodmann's area 28)
hippocampal efferents, subcortical
hippocampal mossy fiber pathway
Schaeffer collaterals
septal nucleus
General
brain structure
References
- The Human Nervous System, George Paxinos,
Academic Press, San Diego CA 1990
- Nakazawa et al.
Requirement for hippocampal CA3 NMDA receptors in associative memory recall
Science 297:211-8, 2002
PMID: 12040087 PMCID: PMC2877140 Free PMC article
- Jhung L
Scientists Find Brain Mechanism Behind Age-Related Memory Loss.
Medscape. July 5, 2022
https://www.medscape.com/viewarticle/976566
- Lee H, Wang Z, Tillekeratne A et al
Loss of functional heterogeneity along the CA3 transverse axis in aging.
Current Biology. 2022 32(12):2681-2693, June 20
PMID: 35597233 PMCID: PMC9233142 Free PMC article
https://www.cell.com/current-biology/fulltext/S0960-9822(22)00713-8
Component-of
cornus ammonis (Ammon's horn)