cornifelin (CNFN)

Function: - part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia - directly or indirectly cross-linked to CE proteins loricin & involucrin Structure: belongs to the cornifelin family Compartment: - cytoplasm - constituent of the scaffolding of the cornified envelope (putative) Expression: - abundant in the cervix - moderately abundant in uterus & fetal skin - expressed in the granular cell layer of normal epidermis Pathology: - expression is markedly increased in psoriatic skin (18.5 fold increase in comparison with normal skin) & its overexpression alters the protein composition of cornified cell envelope, but does not affect keratinocyte differentiation - expressed in upper-spinous layer of epidermis in psoriatic lesions - increased expression also seen in atopic dermatitis (14.3 fold increase in comparison with normal skin) - increased expression also seen in mycosis fungoides (4.6 fold increase in comparison with normal skin) - in both atopic dermatitis & mycosis fungoides, expressed in the granular cell layer of epidermis

Properties

SIZE: MW = 12 kD entity length = 112 aa COMPARTMENT: cytoplasm MOTIF: cysteine-rich region {31-61}

Database Correlations

UniProt Q9BYD5 Pfam PF04749

References

UniProt :accession Q9BYD5