COP9 signalosome complex subunit 5 (signalosome subunit 5, SGN5, Jun activation domain-binding protein 1, COPS5, JAB1)

Function: 1) component of the COP9 signalosome complex 2) in the complex, acts as the catalytic center that mediates cleavage of Nedd8 from cullins 3) no metalloprotease activity by itself, requires other subunits of the CSN complex 4) interacts with other proteins regulated by the CSN complex 5) JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins - may constitute the catalytic center of the complex Cofactor: divalent metal ions Structure: - JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins; it may constitute the catalytic center of the complex - belongs to the peptidase M67A family, CSN5 subfamily - contains 1 MPN (JAB/Mov34) domain Compartment: cytoplasm, nucleus

Properties

SIZE: MW = 37 kD entity length = 333 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl MPN {53-164} MOTIF: JAMM {138-151}

Database Correlations

OMIM 604850 UniProt Q92905 Pfam PF01398 Kegg hsa:1098 ENZYME 3.4.-.-

References

UniProt :accession Q9BT78