COP9 signalosome complex subunit 3 (signalosome subunit 3, SGN3, JAB1-containing signalosome subunit 3, COPS3, JAB3, CSN3)

Function: 1) component of the COP9 signalosome complex 2) in the complex, interacts directly with COPS1, COPS4 & COPS8 3) interacts with CK2, PKD 4) interacts with translation initiation factor EIF3S6 & IKBKG 5) phosphorylated upon DNA damage, probably by ATM or ATR Structure: - belongs to the CSN3 family - contains 1 PCI domain Compartment: cytoplasm, nucleus Expression: - widely expressed - expressed at high level in heart, skeletal muscle Pathology: - amplified & overexpressed in some osteosarcomas

General

phosphoprotein protein subunit

Properties

SIZE: entity length = 423 aa MW = 48 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl PCI {195-362} Ser phosphorylation site {S410}

Database Correlations

OMIM 604665 UniProt Q9UNS2 Pfam PF01399 Kegg hsa:8533

References

UniProt :accession Q9UNS2