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COP9 signalosome complex subunit 2; SGN2; signalosome subunit 2; alien homolog; JAB1-containing signalosome subunit 2; thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP-15 (COPS2, CSN2, TRIP15)
Function:
1) component of the COP9 signalosome complex
2) in the complex, interacts directly with COPS1, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), CUL1, CUL2
3) interacts with ligand binding domain of thyroid receptor
4) interacts with IRF8, NR2F1, NR0B1
5) interacts with NIF3L1 (putative)
6) phosphorylated by CK2 & PKD kinases
Compartment: cytoplasm, nucleus
Alternative splicing: named isoforms=2
Related
triiodothyronine [T3] receptor or erbA proto-oncogene protein
General
other protein
Properties
SIZE: entity length = 443 aa
MW = 52 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: PCI {248-413}
Database Correlations
OMIM 604508
UniProt P61201
PFAM correlations
Entrez Gene 9318
Kegg hsa:9318
References
- OMIM :accession 604508
- UniProt :accession P61201
Component-of
COP9 signalosome complex (CSN complex)