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copeptin in serum

Clinical significance: - assessing prognosis in heart failure - higher serum copeptin levels predict cardiovascular mortality & all cause mortality in patients with heart failure [1] - adding serum copeptin to a model that already includes serum NT-proBNP modestly improves discrimination (increases C-index from 0.74 to 0.76) - used in the CoRisk Score for assessing prognosis in ischemic stroke [2] - median copeptin value in patients with ischemic stroke: 14.2 pmol/L - plasma copeptin* distinguishes diabetes insipidus from primary polydipsia [2] - activity is low in diabetes insipidus - antigen is also low in central diabetes insipidus * fragment of the arginine vasopressin prohormone (test not widely available)

Related

copeptin vasopressin (antidiuretic hormone, ADH)

General

special chemistry test

References

  1. Alehagen U et al. Association of copeptin and N-terminal proBNP concentrations with risk of cardiovascular death in older patients with symptoms of heart failure. JAMA 2011 May 25; 305:2088. PMID: 21610241
  2. Fenske W, Refardt J, Chifu I et al. A copeptin-based approach in the diagnosis of diabetes insipidus. N Engl J Med 2018 Aug 2; 379:428. PMID: 30067922 https://www.nejm.org/doi/10.1056/NEJMoa1803760 - Rosen CJ, Ingelfinger JR. A reliable diagnostic test for hypotonic polyuria. N Engl J Med 2018 Aug 2; 379:483. PMID: 30067935 https://www.nejm.org/doi/10.1056/NEJMe1808195
  3. De Marchis GM, Dankowski T, Konig IR et al. A novel biomarker-based prognostic score in acute ischemic stroke: The CoRisk score. Neurology 2019 Mar 26; 92:e1517. PMID: 30824558 https://n.neurology.org/content/92/13/e1517