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COP9 signalosome complex (CSN complex)
Function:
1) cellular & developmental processes
2) regulates ubiquitin conjugation via deneddylation of cullin subunits of SCF-type E3 ligase complexes
- diminishes ubiquitin E3 ligase activity
3) regulates phosphorylation of p53/TP53, c-jun, NFKBIA, ITPK1, IRF8 via association with CK2 & PKD kinases (putative)
- CSN complex-dependent phosphorylation of TP53 promotes & c-jun phorphorylation protects from degradation by the ubiquitin system
Structure:
- subunits: COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) & COPS8
General
molecular complex
Properties
SUBUNITS: COP9 signalosome complex subunit 2
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: PCI {248-413}
COP9 signalosome complex subunit 1
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: PCI {240-408}
Thr phosphorylation site {T459}
COP9 signalosome complex subunit 3
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
PCI {195-362}
Ser phosphorylation site {S410}
COP9 signalosome complex subunit 4
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: PCI {201-363}
COP9 signalosome complex subunit 5
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
MPN {53-164}
MOTIF: JAMM {138-151}
COP9 signalosome complex subunit 6
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: MPN {39-148}
Vpr binding
NAME: Vpr binding
SITE: 211-327
FOR-BINDING-OF: protein Vpr
COPS7
COP9 signalosome complex subunit 8
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: PCI {68-151}
References
UniProt :accession P61201
Components
COP9 signalosome complex subunit 1 (signalosome subunit 1, SGN1, JAB1-containing signalosome subunit 1, G protein pathway suppressor 1, Protein GPS1, Protein MFH, COPS1, CSN1)
COP9 signalosome complex subunit 2; SGN2; signalosome subunit 2; alien homolog; JAB1-containing signalosome subunit 2; thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP-15 (COPS2, CSN2, TRIP15)
COP9 signalosome complex subunit 3 (signalosome subunit 3, SGN3, JAB1-containing signalosome subunit 3, COPS3, JAB3, CSN3)
COP9 signalosome complex subunit 4 (signalosome subunit 4, SGN4, JAB1-containing signalosome subunit 4, COPS4, CSN4)
COP9 signalosome complex subunit 5 (signalosome subunit 5, SGN5, Jun activation domain-binding protein 1, COPS5, JAB1)
COP9 signalosome complex subunit 6 (signalosome subunit 6, SGN6, JAB1-containing signalosome subunit 6, Vpr-interacting protein, hVIP, MOV34 homolog, COPS6, CSN6)
COP9 signalosome complex subunit 8 (signalosome subunit 8, SGN8, JAB1-containing signalosome subunit 8, COP9 homolog, hCOP9, COPS8, JAB8, CSN8)