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conidiobolomycosis
Etiology:
- Conidiobolus coronatus
- Conidiobolus incongruus
- Conidiobolus lamprauges
Epidemiology:
- rare
- predominately affects middle age men in tropical countries
- due to infection with saprophytic fungus that can survive in soil & dried vegetables for long periods of time
Pathology:
- affects upper respiratory mucosa & adjacent subcutaneous tissues
- infection probably results from inhalation of fungal pathogens or from trauma.
Microscopic pathology:
- granulomatous inflammation & fungal elements surrounded by eosinophilic material
Clinical manifestations:
- mycosis of nose & paranasal sinuses
- erythema, edema, & tenderness over the nasal dorsum & forehead, extending to the soft tissue around both eyes (case report [4])
- case of disseminiated conidiobolomycosis caused by Conidiobolus lamprauges in a patient with malignant lymphoma [2]
Laboratory:
- skin biopsy
Management:
- itraconazole, trimethoprim-sulfamethoxazole & 10% potassium iodide for 6 months (case report) [4]
Related
Conidiobolus
General
entomophthoramycosis
References
- Wikipedia: Conidiobolomycosis
https://en.wikipedia.org/wiki/Conidiobolomycosis
- Dutta S, Sarkar S, Linka U, Dora S.
Conidiobolomycosis: A case report of rare fungal infection
from the eastern India.
Indian Dermatol Online J. 2015 Nov-Dec;6(6):393-5.
PMID: 26753137 Free PMC Article
- Kimura M, Yaguchi T, Sutton DA et al
Disseminated Human Conidiobolomycosis Due to Conidiobolus
lamprauges.
J. Clin. Microbiol. February 2011 vol. 49 no. 2 752-756
PMID: 21147951 Free PMC Article
http://jcm.asm.org/content/49/2/752.full
- Cao C, Khader JA
Rhinofacial Entomophthoromycosis.
N Engl J Med 2018; 378:e13
PMID: 29490172
http://www.nejm.org/doi/full/10.1056/NEJMicm1709956?query=TOC