condensin

Function: 1) conversion of interphase chromatin into mitotic-like condense chromosomes 2) introduces positive supercoils into relaxed DNA in the presence of topoisomerase 1 & converts nicked DNA into positive knotted forms in the presence of topoisomerase 2 Structure: - components include: - SMC2L1 & SMC4L1 heterodimer, & 3 regulatory components BRRN1/CAPH, CNAP1/CAPD2 & NCAPG Compartment: - in interphase cells, most condensin is found in the cytoplasm, less is associated with chromatin - during mitosis, most condensin is associated with chromatin - with onset of prophase, regulatory subunits of condensin are phosphorylated by CDC2, leading to condensin's association with chromosome arms & to chromosome condensation - dissociation from chromosomes occurs in late telophase

Related

condensin complex (GO:0000796) condensin-2

Properties

SUBUNITS: structural maintenance of chromosome 2-like 1 protein COMPARTMENT: cytoplasm cell nucleus MOTIF: ATP-binding site NAME: ATP-binding site SITE: 32-39 coiled coil {173-507} coiled coil {672-926} coiled coil {963-1031} structural maintenance of chromosomes 4-like 1 protein COMPARTMENT: cytoplasm cell nucleus MOTIF: proline-rich region SITE: 18-23 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S22} Ser phosphorylation site {S28} Ser phosphorylation site {S41} proline-rich region SITE: 66-71 MOTIF: proline residue (SEVERAL) ATP-binding site NAME: ATP-binding site SITE: 113-120 coiled coil {272-588} coiled coil {767-1020} Ser phosphorylation site {S1056} coiled coil {1109-1129}

References

UniProt :accession Q99743

Components

structural maintenance of chromosome 2-like 1 protein (chromosome-associated protein E, hCAP-E, XCAP-E homolog, SMC2L1, CAPE, SMC2, PRO0324) structural maintenance of chromosomes 4-like 1 protein (chromosome-associated polypeptide C, hCAP-C, XCAP-C homolog, SMC4L1, CAPC, SMC4)