Search
complement-3 (C3)
Held in a strained configuration by thioester Cys-338 - Glu-341 in alpha chain; alpha & beta chains linked by disulfide bridge. Defects in complement C3:
1) etiology
a) congenital liver disease
b) systemic lupus erythematosus
2) pathogens
a) Staphylococcus aureus
b) Streptococcus pneumonia
c) Pseudomonas species
d) Proteus species
Interactions
molecular events
Related
complement C3 in serum
complement cascade
Specific
complement C3a
complement C3b
complement C3c
complement C3d
complement C3dg
complement C3f
complement C3g
complement C3[H2O] (iC3)
General
acute phase protein
beta 2 globulin
complement
glycoprotein
multisubunit protein
Properties
SIZE: MW = 195 kD
COMPARTMENT: plasma
MOTIF: glycosylation site
SUBUNITS: complement C3-alpha chain
:STATE Inactive
complement C3-beta chain
MISC-INFO: CONCENTRATION 60-140 MG/DL
Database Correlations
OMIM 120700
MORBIDMAP 120700
UniProt P01024
References
- Tietz Fundametals of Clinical Chemistry 3rd ed, WB
Saunders, 1987 pg 327
- Clinical Diagnosis and Management by Laboratory
Methods, 18th ed, J.B. Henry (ed), W.B. Saunders,
Philadelphia, PA, 1991 pg 832
- Harrison's Principles of Internal Medicine, 13th ed.
Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 497
Components
complement C3-alpha chain
complement C3-beta chain