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complement C1r
Upon activation is cleaved into A & B chains bound by disulfide linkage; B chain contains catalytic site.
Interactions
molecular events
General
complement-activating enzyme
complement
glycoprotein
inter alpha globulin
serine protease trypsin family
Properties
SIZE: MW = 83 kD
COMPARTMENT: membrane
MOTIF: active site
glycosylation site
EGF domain
allosteric site (2)
FOR-BINDING-OF: complement C1 inhibitor
STATE: active state
Database Correlations
OMIM 216950
UniProt P00736
ENZYME 3.4.21.41
References
- Baron M, Norman DG, Campbell ID.
Protein modules.
Trends Biochem Sci. 1991 Jan;16(1):13-7. Review.
PMID: 2053133
- OMIM :accession 216950
Component-of
complement-1 (C1)