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collagenase ointment (SANTYL)
Indications:
- debridement of chronic cutaneous ulcers & severely burned areas
- diabetic foot ulcers
Contraindications:
- local or systemic hypersensitivity to collagenase
- not indicated for wound closure
Caution:
1) for external use only
2) avoid contact with eyes
3) monitor debilitated patients; debriding enzymes may increase risk of bacteremia
Dosage:
- topical, apply QD
- discontinue use when granulation tissue is well-established
Ointment: 250 units/g. 15 & 30 g.
Pharmacokinetics:
- optimal pH range of collagenase is 6-8
Adverse effects:
- theoretical possibility collagenase may increase the risk of bacteremia
- transient erythema especially if collagenase not confined to wound
Drug interactions:
- detergents
- benzalkonium chloride
- hexachlorophene
- nitrofurazone
- tincture of iodine
- heavy metal ions such as mercury & silver used in some antiseptics
Mechanism of action:
- digestion of collagen (75% of dry weight of skin tissue) facilitates removal of detritus from cutaneous wounds
Related
collagenase clostridium histolyticum (CCH, Xiaflex, Qwo)
General
collagenase
musculoskeletal system agent
References
- Collagenase SANTYL Oimtnent 250 units/g
https://santyl.com/sites/default/files/2019-12/SANTYL-PI.pdf