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collagen type-3
Function:
- frequently together with type 1 collagen
- collagen of granulation tissue
- produced quickly by young fibroblasts before the tougher type-1 collagen is synthesized
- forms reticular fiber
Pathology:
- defects associated with Ehlers-Danlos Syndrome
Related
procollagen type 3 in serum
procollagen type 3 in urine
General
collagen
Properties
COMPARTMENT: extracellular matrix
WITHIN: skin
muscle
SECRETED-BY: fibroblast
hepatocyte
SUBUNITS: collagen 3 alpha-1 (3)
MOTIF: signal sequence {1-23}
VWFC domain {30-89}
Nonhelical region (N-terminal) {149-167}
Triple-helical region {168-1196}
MOTIF: cysteine residue {C1196}
MODIFICATION: cysteine residue {C-INTERCHAIN}
Nonhelical region (C-terminal) {1197-1205}
MOTIF: cysteine residue {C1197}
MODIFICATION: cysteine residue {C-INTERCHAIN}
Fibrillar collagen NC1 {1232-1466}
MOTIF: Tyr phosphorylation site {Y1378}
Ser phosphorylation site {S1383}
References
- Molecular Cell Biology (2nd ed) Darnell J; Lodish H
& Baltimore D (eds), Scientific American Books,
WH Freeman, NY 1990, pg 920
- Wikipedia, collagen entry
http://en.wikipedia.org/wiki/collagen
Components
collagen 3 alpha-1