Contents

Search

collagen type-4

Function: - the most important basement membrane collagen - component of the filtration system in capillaries & the glomeruli of renal nephrons - receptor is integrin alpha-1/beta-1 Compartment: - basement membrane - capillaries - renal glomeruli - lens of eye Expression: - capillaries - kidney - lens of eye Pathology: - defects associated with Alport syndrome - role in pathogenesis of psoriasis [2]

Related

collagen type 4 Ag in tissue

General

collagen

Properties

COMPARTMENT: basal lamina SECRETED-BY: epithelial cell* endothelial cell hepatocyte SUBUNITS: collagen 4 alpha-1 (2) MOTIF: signal sequence {1-27} N-glycosylation site {N126} Triple-helical region {173-1440} Collagen IV NC1 {1445-1669} MOTIF: cysteine residue {C1460} MODIFICATION: cysteine residue {C1551} cysteine residue {C1493} MODIFICATION: cysteine residue {C1548} cysteine residue {C1505} MODIFICATION: cysteine residue {C1511} cysteine residue {C1511} MODIFICATION: cysteine residue {C1505} cysteine residue {C1548} MODIFICATION: cysteine residue {C1493} cysteine residue {C1551} MODIFICATION: cysteine residue {C1460} cysteine residue {C1570} MODIFICATION: cysteine residue {C1665} cysteine residue {C1604} MODIFICATION: cysteine residue {C1662} cysteine residue {C1616} MODIFICATION: cysteine residue {C1622} cysteine residue {C1622} MODIFICATION: cysteine residue {C1616} cysteine residue {C1662} MODIFICATION: cysteine residue {C1604} cysteine residue {C1665} MODIFICATION: cysteine residue {C1570} collagen 4 alpha-2 MOTIF: signal sequence {1-25} N-glycosylation site {N138} Triple-helical region {184-1484} Collagen IV NC1 {1489-1712} MOTIF: cysteine residue {C1504} MODIFICATION: cysteine residue {C1593} cysteine residue {C1537} MODIFICATION: cysteine residue {C1590} cysteine residue {C1549} MODIFICATION: cysteine residue {C1555} cysteine residue {C1555} MODIFICATION: cysteine residue {C1549} cysteine residue {C1590} MODIFICATION: cysteine residue {C1537} cysteine residue {C1593} MODIFICATION: cysteine residue {C1504} cysteine residue {C1612} MODIFICATION: cysteine residue {C1708} cysteine residue {C1646} MODIFICATION: cysteine residue {C1705} cysteine residue {C1658} MODIFICATION: cysteine residue {C1665} cysteine residue {C1665} MODIFICATION: cysteine residue {C1658} cysteine residue {C1705} MODIFICATION: cysteine residue {C1646} cysteine residue {C1708} MODIFICATION: cysteine residue {C1612}

References

  1. Molecular Cell Biology (2nd ed) Darnell J; Lodish H & Baltimore D (eds), Scientific American Books, WH Freeman, NY 1990, pg 920
  2. Conrad C, Boyman O, Tonel G, Tun-Kyi A, Laggner U, de Fougerolles A, Kotelianski V, Gardner H, Nestle FO. alpha(1)beta(1) integrin is crucial for accumulation of epidermal T cells and the development of psoriasis. Nat Med. 2007 Jul;13(7):836-42. Epub 2007 Jul 1. PMID: 17603494
  3. Wikipedia, collagen entry http://en.wikipedia.org/wiki/collagen

Components

collagen 4 alpha-1; contains: arresten (COL4A1) collagen 4 alpha-2; contains: canstatin (COL4A2)