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collagen 19 alpha-1; ; collagen alpha-1(Y) (COL19A1)
A FACIT collagen
Function:
- may act as a cross-bridge between fibrils & other extracellular matrix molecules
- role in skeletal myogenesis in the developing esophagus
- may play a role in organization of the pericellular matrix or the sphinteric smooth muscle
- Pro at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains oligomer; disulfide-linked
Structure:
- numerous interruptions in the triple helix may make COL19A1 either elastic or flexible
- belongs to the fibril-associated collagens with interrupted helices (FACIT) family
- contains 1 TSP N-terminal (TSPN) domain
Compartment:
- secreted, extracellular space, extracellular matrix (putative)
Expression:
- localized to vascular, neuronal, mesenchymal, & some epithelial basement membrane zones in umbilical cord
General
collagen subunit
Properties
SIZE: entity length = 1142 aa
MW = 115 kD
MOTIF: signal sequence {1-23}
TSP N-terminal {50-234}
Triple-helical region (COL1) {292-351}
Triple-helical region (COL2) {370-429}
Triple-helical region (COL3) {448-688}
Triple-helical region (COL4) {700-818}
Triple-helical region (COL5) {833-1012}
MOTIF: Cell attachment {952-954}
Triple-helical region (COL6) {1054-1111}
Database Correlations
OMIM 120165
UniProt Q14993
Pfam PF01391
Entrez Gene 1310
Kegg hsa:1310
References
UniProt :accession Q14993