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collectin-12 (collectin placenta protein 1, CL-P1, hCL-P1, nurse cell scavenger receptor 2, scavenger receptor with C-type lectin, scavenger receptor class A member 4, COLEC12, CLP1, NSR2, SCARA4, SRCL)
Function:
- scavenger receptor that displays several functions associated with host defense
- promotes binding & phagocytosis of Gram-positive, Gram-negative bacteria & yeast
- mediates recognition, internalization & degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells
- binds to several carbohydrates including gal-type ligands, D-galactose, L- & D-fucose, galNAc, T & Tn antigens (Ca+2-dependent) & internalizes specifically galNAc in nurse-like cells
- binds also to sialyl Lewis X or a trisaccharide & asialo-orosomucoid (ASOR)
- may also play a role in the clearance of amyloid beta in Alzheimer disease
- extracellular domain forms a stable trimer
- extracellular domain interacts with fibrillar beta amyloid peptide
Structure:
- contains 1 C-type lectin domain
- contains 3 collagen-like domains
Compartment:
- membrane, forms clusters on the cell surface
Alternative splicing: named isoforms=2
Expression:
- expressed in perivascular macrophages
- strongly expressed in placenta
- moderately expressed in heart, skeletal muscle, small intestine & lung
- weakly expressed in brain, colon, thymus & kidney
- expressed in nurse-like cells Patholohy
- expressed in plaques-surrounding reactive astrocytes & in perivascular astrocytes associated with cerebral amyloid angiopathy in the temporal cortex of Alzheimer patient (at protein level)
General
Ca+2 binding protein
collectin
membrane protein
receptor
Properties
SIZE: entity length = 742 aa
MW = 82 kD
COMPARTMENT: plasma membrane
MOTIF: transmembrane domain {38-58}
coiled coil {73-141}
coiled coil {215-328}
Collagen-like 1 {443-472}
Collagen-like 2 {473-529}
Collagen-like 3 {530-589}
cysteine residue {C607}
MODIFICATION: cysteine residue {C618}
C-type lectin {614-731}
MOTIF: cysteine residue {C618}
MODIFICATION: cysteine residue {C607}
cysteine residue {C635}
MODIFICATION: cysteine residue {C730}
Ca+2-binding site
SITE: 644-644
Ca+2-binding site
SITE: 646-646
Ca+2-binding site
SITE: 650-650
Ca+2-binding site
SITE: 670-670
Ca+2-binding site
SITE: 674-674
binding site
SITE: 691-691
FOR-BINDING-OF: Carbohydrate
Ca+2-binding site
SITE: 694-694
binding site
SITE: 694-694
FOR-BINDING-OF: Carbohydrate
Ca+2-binding site
SITE: 696-696
binding site
SITE: 696-696
FOR-BINDING-OF: Carbohydrate
Ca+2-binding site
SITE: 697-697
Ca+2-binding site
SITE: 706-706
binding site
SITE: 706-706
FOR-BINDING-OF: Carbohydrate
Ca+2-binding site
SITE: 707-707
cysteine residue {C708}
MODIFICATION: cysteine residue {C722}
Ca+2-binding site
SITE: 718-718
binding site
SITE: 718-718
FOR-BINDING-OF: Carbohydrate
Ca+2-binding site
SITE: 719-719
binding site
SITE: 719-719
FOR-BINDING-OF: Carbohydrate; via carbonyl oxygen
cysteine residue {C722}
MODIFICATION: cysteine residue {C708}
cysteine residue {C730}
MODIFICATION: cysteine residue {C635}
Ca+2-binding site
SITE: 731-731
Database Correlations
OMIM 607621
UniProt Q5KU26
PFAM correlations
Kegg hsa:8103
References
UniProt :accession Q5KU26