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cold analgesia
Indications:
- targeted & reversible blocking of peripheral nerve activity for treating pain
Mechanism of action:
- soft, miniaturized, implantable cooler temporarily blocks nerve conduction using a liquid-to-gas phase transition as the cooling mechanism
- nerve cuff with a microfluidic channel carrying a microliter volume of bioinert coolant
- thermal thin-film sensor integrated within the cuff enables temperature monitoring in real time, enabling closed-loop control.
- the nerve block by the coolant prevents afferent tramsmission of pain signals [1]
General
cold therapy
analgesia
References
- Reeder JT, Xie Z, Yang Q et al
Soft, bioresorbable coolers for reversible conduction block of peripheral nerves.
Science. 2022 377(6601):109-115 Jun 30.
PMID: 35771907
https://www.science.org/doi/10.1126/science.abl8532