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sodium docusate (Colace, DOSS, DSS)
Tradename: Colace. (a stool softener)
Indications:
- relief of constipation
- softening of earwax (off label)
Contraindications:
Pregnancy category :value +
Safety in lactation :value ?
Dosage:
- 100 mg PO QD/BID.
- Pediatrics:
- 10-400 mg/dose < 3 yr.
- 20-60 mg/dose 3-6 yr
- Earwax: 1 mL liquid
Tabs: 50, 100, 240, 250 mg.
Liquid: 20 & 50 mg/5 mL.
Pharmacokinetics:
1) stool softening occurs in 1-3 days
2) metabolized by liver
Adverse effects:
1) gastrointestinal (1-10%)
a) diarrhea
b) abdominal cramping
c) intestinal obstruction (rare)
2) throat irritation
Drug interactions:
1) Colace causes increased systemic absorption of mineral oil leading to fatty liver infiltrates
2) increased toxicity of phenolphthalein
Mechanism of action:
1) stool softener
2) maintains stool hydration
3) reduces surface tension of the oil-water interface of the stool, resulting in enhanced incorporation of water & fat allowing for stool softening
4) the salts are interchangeable, i.e. the amount of cation Ca+2, K+, Na+ per unit dose is clinically insignificant
General
docusate
Database Correlations
PUBCHEM cid=11338
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Drug Information & Medication Formulary, Veterans Affairs,
Central California Health Care System, 1st ed., Ravnan et al
eds, 1998
Department of Veterans Affairs, VA National Formulary
- Drug information Handbook, Lacy, C, Lexi-Comp, Inc.
Component-of
alpha tocopherol/ascorbate/beta carotene/calcium carbonate/cholecalciferol/cobalamin/ferrous fumarate/folic acid/nicotinamide/pantothenate/pyridoxine/riboflavin/sodium docusate/thiamine/zinc oxide
alpha tocopherol/ascorbate/calcium carbonate/carbonyl iron/cholecalciferol/cobalamin/cupric oxide/folic acid/magnesium oxide/nicotinamide/pyridoxine/riboflavin/sodium docusate/thiamine/zinc oxide
alpha tocopherol/ascorbate/calcium citrate/carbonyl iron/cholecalciferol/docosahexaenoate/folic acid/nicotinamide/potassium iodide/pyridoxine/riboflavin/sodium docusate/thiamine/zinc oxide
alpha tocopherol/ascorbate/calcium citrate/carbonyl iron/cholecalciferol/folic acid/nicotinamide/potassium iodide/pyridoxine/riboflavin/sodium docusate/thiamine/zinc oxide
alpha tocopherol/ascorbate/calcium phosphate/cholecalciferol/docosahexaenoate/ferrous fumarate/folic acid/pyridoxine/sodium docusate
alpha tocopherol/ascorbate/calcium phosphate/docosahexaenoate/ferrous fumarate/folic acid/pyridoxine/sodium docusate
alpha tocopherol/ascorbate/cholecalciferol/docosahexaenoate/ferrous fumarate/folic acid/pyridoxine/sodium docusate
alpha tocopheryl acetate/ascorbate/biotin/carbonyl iron/cobalamin/copper sulfate/folic acid/sodium docusate
alpha tocopheryl acetate/ascorbate/biotin/carbonyl iron/cobalamin/folic acid/sodium docusate
ascorbate/beta carotene/calcium carbonate/carbonyl iron/cholecalciferol/cobalamin/folic acid/magnesium oxide/nicotinamide/pyridoxine/riboflavin/sodium docusate/thiamine/zinc oxide
ascorbate/carbonyl iron/cobalamin/folic acid/sodium docusate
ascorbate/cobalamin/folic acid/iron carbonyl/sodium docusate
ascorbate/cobalamin/folic acid/sodium docusate
benzocaine/sodium docusate
casanthranol/sodium docusate
ferrous fumarate/sodium docusate
casanthranol/docusate (Peri-Colace)
phenolphthalein/sodium docusate
senna/sodium docusate; sennosides-docusate sodium; senokot-S, senna-S