collagen 6 alpha-6 (COL6A6)

Function: - collagen 6 acts as a cell-binding protein - Pro at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains - trimers composed of three different chains: COL6A1, COL6A2, & COL6A3 or COL6A5 or COL6A6 (probable) Structure: - belongs to the type VI collagen family - contains 9 VWFA domains Compartment: - secreted, extracellular space, extracellular matrix (putative) - deposed in the extracellular matrix of skeletal muscle (putative) Alternative splicing: named isoforms=2

General

glycoprotein secreted protein

Properties

SIZE: entity length = 2263 aa MW = 247 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-19} Nonhelical region {20-1391} MOTIF: VWFA domain {27-206} N-glycosylation site {N198} VWFA domain {229-411} N-glycosylation site {N275} N-glycosylation site {N347} VWFA domain {436-606} N-glycosylation site {N520} VWFA domain {622-791} VWFA domain {809-982} VWFA 6 {1000-1171} VWFA 7 {1187-1371} Triple-helical region {1392-1725} MOTIF: Cell attachment {1508-1510} Nonhelical region {1726-2263} MOTIF: VWFA 8 {1757-1937} VWFA 9 {1965-2166}

Database Correlations

UniProt A6NMZ7 PFAM correlations Entrez Gene 131873 Kegg hsa:131873

References

UniProt :accession A6NMZ7