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collagen 25 alpha-1; CLAC-P; Alzheimer disease amyloid-associated protein; AMY; contains: collagen-like Alzheimer amyloid plaque component (CLAC) (COL25A1)
Function:
1) inhibits fibrillization of beta amyloid peptide during elongation
2) assembly of amyloid fibrils into protease-resistant aggregates
3) binds heparin
4) binds to fibrillized forms of beta amyloid peptide 40 & more frequently with beta amyloid peptide 42
5) glycosylated
Structure:
1) forms homodimers & homotrimers
2) hydroxylated on 11% of PRO & 49% of LYS
3) contains 7 collagen-like domains
Compartment:
- membrane
- after proteolytic cleavage, CLAC is secreted
Alternative splicing: named isoforms=3
Expression: expressed predominantly in brain
Pathology:
- deposited in primitive or neuritic amyloid plaques
- proteolytic cleavage by furin protease to yield soluble collagen-like Alzheimer amyloid plaque component
Related
A4 amyloid peptide; beta-peptide
amyloid precursor protein (APP) or A4/beta amyloid precursor protein
General
collagen subunit
glycoprotein
membrane protein
Properties
SIZE: MW = 65 kD
entity length = 654 aa
MOTIF: transmembrane domain {34-54}
proteolytic site {112-113}
Collagen-like 1 {121-164}
binding site
SITE: 181-188
FOR-BINDING-OF: A4 amyloid peptide
Collagen-like 2 {192-247}
Collagen-like 3 {249-308}
Collagen-like 4 {311-370}
Collagen-like 5 {372-425}
Collagen-like 6 {447-505}
Collagen-like 7 {571-630}
Database Correlations
OMIM 610004
UniProt Q9BXS0
Pfam PF01391
Entrez Gene 84570
Kegg hsa:84570
References
UniProt :accession Q9BXS0