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exceptional cognitive resilience
general capacity of cognitive processes to be less susceptible to changes in brain structure from age & disease
Genetics:
- apoE2 allele increases likelihood of exceptional cognitive resilience [4]
- apoE4 allele decreases likelihood of exceptional cognitive resilience [4]
- see PSEN2 gene mutation for case report of an exceptional resilience mutation carrier [3]
Clinical significance:
- supportive social networks reduce risk of Alzheimer disease & related disorders by enhancing cognitive resilience
- cognitively intensive Tai chi results in greater improvement of cognition measures than standard Tai chi or stretching in elderly with mild cognitive impairment [2]
Management:
- see
- prevention of Alzheimer's disease
- investigational treatment of Alzheimer's disease
Related
prevention of Alzheimer's disease/dementia
social support
SuperAger (exceptional cognition in the elderly)
General
cognition (intelligence)
resilience
References
- Salinas J, O'Donnell A, Kojis DJ et al
Association of Social Support With Brain Volume and Cognition.
JAMA Netw Open. 2021;4(8):e2121122. August 16
PMID: 34398201 Free article
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2783042
- Li F, Harmer P, Eckstrom E et al
Clinical Effectiveness of Cognitively Enhanced Tai Ji Quan Training on Global
Cognition and Dual-Task Performance During Walking in Older Adults With Mild
Cognitive Impairment or Self-Reported Memory Concerns.
A Randomized Controlled Trial.
Ann Intern Med. 2023. Oct 31.
37903365
https://www.acpjournals.org/doi/10.7326/M23-1603
- Reardon S
A man was destined for early Alzheimer's - these genes might explain
his escape
Nature News. Feb 10 2025
https://www.nature.com/articles/d41586-025-00398-4
- Llibre-Guerra JJ, Fernandez MV, Joseph-Mathurin N et al
Longitudinal analysis of a dominantly inherited Alzheimer disease mutation
carrier protected from dementia.
Nat Med. 2025 Feb 10.
PMID: 39930140
https://www.nature.com/articles/s41591-025-03494-0
- Durant A, Mukherjee S, Lee ML et al
Evaluating the association of apolipoprotein E genotype and cognitive
resilience in SuperAgers.
Alzheimers Dement. 2026 Jan;22(1):e71024.
PMID: 41542929 PMCID: PMC12809718 Free PMC article.
https://pmc.ncbi.nlm.nih.gov/articles/PMC12809718/