Search
cognitive frailty
Reduced cognitive function in the absence of subjective memory complaints, or a clinical diagnosis of dementia. [1]
Etiology:
- lower cognitive reserve, hearing impairment, & cardiovascular comorbidity might contribute to cognitive frailty.
Pathology:
- proposed to be a precursor to Alzheimer's disease
- alternatively may represent separate process of inevitable cognitive aging
- cognitively frail have larger temporal gray matter volume, compared with people with mild cognitive impairment or Alzheimer's disease
- structural atrophy is absent
Clinical manifestations:
- cognitive performance similar to adults with mild cognitive impairment
- neurophysiological signatures of Alzheimer's disease are absent
Differential diagnosis:
- distinct from cognitive impairment caused by physical frailty
Management:
- community-based multicomponent exercises may improve cognitive function & frailty status in elderly persons [2]
- for hospitalized elderly, nutritional support may be the most effective intervention to improve cognitive function [2]
- aerobic exercise & dual-task training may be of benefit [2]
General
frailty
References
- Kocagoncu E, Nesbitt D, Emery T et al
Neurophysiological and Brain Structural Markers of Cognitive Frailty Differ
from Alzheimer's disease.
Journal of Neuroscience 2022. January 10.
https://www.jneurosci.org/content/early/2022/01/02/JNEUROSCI.0697-21.2021
- Zhang Y, Zhou JJ, Zhang XM, et al.
Management of cognitive frailty: A network meta-analysis of randomized controlled
trials.
Int J Geriatr Psychiatry. 2023 Sep;38(9):e5994.
PMID: 37655500
https://journalwise.acponline.org/Articles/SpecialtyAlert/110599