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coagulation factor VIII alloantibody
Alloantibody to factor VIII occurs in 20-25% of patients with severe hemophilia A transfused with factor VIII.
Laboratory:
- prolonged aPTT, NOT corrected with addition of normal plasma
- coagulation factor VIII inhibitor in plasma
Management:
1) immunosuppressive therapy
2) acute bleeding
a) porcine factor VIII (generally less reactive with anti-human factor VIII)
b) prothrombin complex concentrate
c) recombinant factor VIIa concentrate
d) plasmapheresis
Interactions
drug adverse effects of antithrombotic agent(s)
Related
coagulation factor VIII autoantibody (acquired hemophilia)
coagulation factor VIII inhibitor in plasma
coagulation factor VIII; antihemophilic factor; AHF; procoagulant component; contains: factor VIIIa heavy chain, 200 kD & 92 isoforms; factor VIII B chain; factor VIIIa light chain (F8, F8C)
General
alloantibody
coagulation factor VIII antibody
References
Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998