coagulation factor V autoantibody

Etiology: 1) spontaneous (20%) 2) exposure to bovine factor V present in topical thrombin or 'surgical glue' used in surgical procedures (80%) Epidemiology: uncommon Pathology: 1) heterologous antibodies to bovine factor V cross-react with human factor V 2) serious, even fatal bleeding may occur Laboratory: - prolongation of PT & aPTT; neither corrects with addition of normal plasma

Related

coagulation factor V inhibitor in plasma coagulation factor V; activated protein C cofactor; proaccelerin, labile factor; contains: coagulation factor V heavy chain; coagulation factor V light chain (F5)

General

autoantibody coagulation factor antibody

References

Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998