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fibrinogen; coagulation factor-1
Function:
- clot structural protein, gels to form clot; (distinguish from factor I (i)).
Structure:
- subunits:
- fibrinogen alpha
- fibrinogen beta
- fibrinogen gamma
Physiology:
- selective cleavage of Arg-|-Gly bonds in fibrinogen by thrombin forms fibrin & releases fibrinopeptide A & fibrinopeptide B
Laboratory:
- fibrinogen in plasma
- fibrinogen fragments in plasma
- fibrinogen fragments in urine
Interactions
molecular events
Related
coagulation cascade
fibrin
fibrinogen Ag in specimen
fibrinogen in plasma
fibrinogen-like protein 1; HP-041; hepassocin; hepatocyte-derived fibrinogen-related protein 1; HFREP-1; liver fibrinogen-related protein 1; LFIRE-1 (FGL1 HFREP1)
Specific
cryofibrinogen
fibrinogen concentrate (RiaSTAP)
Fibrinogen Parenteral
Fibrinogen Topical
fibrinogen variant
General
coagulation factor
glycoprotein
multisubunit protein
protein precursor
Properties
SIZE: MW = 340 kD
COMPARTMENT: plasma
PRECURSOR-FOR: fibrin
SUBUNITS: fibrinogen-alpha
MOTIF: PEST region
glycosylation site
disulfide bridge
fibrinogen-beta
MOTIF: PEST region
glycosylation site
disulfide bridge
fibrinogen-gamma
MOTIF: disulfide bridge
fibrinogen-alpha'
MOTIF: PEST region
glycosylation site
disulfide bridge
fibrinogen-beta'
MOTIF: PEST region
glycosylation site
disulfide bridge
fibrinogen-gamma'
MOTIF: PEST region
glycosylation site
disulfide bridge
MISC-INFO: 1/2life 3.5-4 DAYS
CONCENTRATION 100-400 MG/DL
References
- White et al Principles of Biochemistry, McGraw Hill
Inc., New York, NY 1978 pg 918
- Levy JH, Goodnough LT.
How I use fibrinogen replacement therapy in acquired bleeding.
Blood. 2015 Feb 26;125(9):1387-93. Epub 2014 Dec 17.
PMID: 25519751 Free Article
Component-of
calcium chloride/fibrinogen/fibrinolytic inhibitor/thrombin
fibrinogen concentrate/thrombin; fibrin sealant (Raplixa)
fibrinogen/thrombin
Components
fibrinogen-alpha (FGA)
fibrinogen-alpha'
fibrinogen-beta (FGB)
fibrinogen-beta'
fibrinogen-gamma
fibrinogen-gamma'