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coagulase-negative Staphylococcus

Staphylococcus spp other than Staphylococcus aureus Clinical significance: - coagulase-negative Staphylococci are generally non-pathogenic organisms Laboratory: - coagulase test is negative* - Staphylococcus coagulase negative DNA * Staphylococcus aureus distinguished from other Staphylococci by the production of coagulase (coagulase test) Management: - stop IV antibiotics for coagulase-negative staphylococcal bacteremia if single positive culture with no metastatic or catheter site infection or indwelling prosthetic devices [2] - 5 days of IV antibiotics for coagulase-negative staphylococcal bacteremia with positive blood cultures 2 days apart - 7-28 days of IV antibiotics for complicated coagulase-negative staphylococcal bacteremia - daptomycin/vancomycin (for methicillin-resistant infection) - anti-staphylococcal penicillin or cefazolin for methicillin-sensitive infection

General

Staphylococcus

References

  1. Clinical Diagnosis & Management by Laboratory Methods, 19th edition, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1996, pg 1137
  2. Holland TL, Raad I, Boucher HW et al. Effect of algorithm-based therapy vs usual care on clinical success and serious adverse events in patients with staphylococcal bacteremia: A randomized clinical trial. JAMA 2018 Sep 25; 320:1249. PMID: 30264119 https://jamanetwork.com/journals/jama/fullarticle/2703352 - Perencevich EN. Malani PN. Treatment algorithms for staphylococcal bacteremia: Improving clinical care and enhancing antimicrobial stewardship. JAMA 2018 Sep 25; 320:1243. PMID: 30264099 https://jamanetwork.com/journals/jama/fullarticle/2703302