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cornichon homolog 1; CNIH-1; cornichon family AMPA receptor auxiliary protein 1; protein cornichon homolog; T-cell growth-associated molecule 77; TGAM77 (CNIH1 CNIH CNIL UNQ155/PRO181)
Function:
- role in selective transport & maturation of TGF-alpha family proteins
- interacts with AREG immature precursor & with immature TGFA, i.e. with a prosegment & lacking full N-glycosylation, but not with the fully N-glycosylated form
- in the Golgi, may form a complex with GORASP55 & transmembrane TGFA
Structure: belongs to the cornichon family
Compartment: membrane
Expression:
- expressed in heart, liver, skeletal muscle, pancreas, adrenal medulla & cortex, thyroid, testis, spleen, appendix, peripheral blood lymphocytes, bone marrow > brain, placenta, lung, kidney, ovary, small intestine, stomach, lymph node, thymus, fetal liver
Pathology:
- expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study)
General
cornichon family protein
Properties
SIZE: entity length = 144 aa
MW = 17 kD
COMPARTMENT: golgi
endoplasmic reticulum
MOTIF: cytoplasmic domain {1-10}
transmembrane domain {11-31}
exoplasmic loop {32-56}
transmembrane domain {57-77}
cytoplasmic loop {78-122}
transmembrane domain {123-143}
exoplasmic domain {144-144}
Database Correlations
OMIM 611287
UniProt O95406
Pfam PF03311
Entrez Gene 10175
Kegg hsa:10175
References
UniProt :accession O95406