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cloxacillin (Cloxapen, Tegopen)
Tradename: Cloxapen. 2nd generation penicillin.
Indications:
- antibiotic therapy for penicillinase-producing Staphylococcal infections
a) respiratory tract infections
- upper respiratory tract infections
- sinusitis
- pharyngitis
- lower respiratory tract infections
b) skin or soft tissue infections
c) infectious arthritis, osteomyelitis
d) urinary tract infection
e) endocarditis
f) septicemia
g) cholangitis
h) meningitis
- empiric treatment for fever of unknown origin [3]
Contraindications: Caution:
1) monitor PT in patients on warfarin
2) elimination of drug is diminished with renal insufficiency
3) use with caution in patients with cephalosporin allergy
Dosage:
1) adults & children > 20 kg: 250-500 mg PO QID
2) children (> 1 month & < 20 kg); 50-100 mg/kg/day PO divided every 6 hours
Tabs: 250 & 500 mg.
Liquid: (powder for oral suspension): 125 mg/5 mL.
Adverse effects:
1) not common (1-10%)
- nausea, diarrhea
2) uncommon (< 1%)
- fever, rash, vomiting, eosinophilia, leukopenia, neutropenia, thrombocytopenia, agranulocytosis, hepatotoxicity, hematuria, serum-sickness like reaction
Drug interactions:
1) effect of oral contraceptives may be reduced
2) disulfiram & probenecid may increase penicillin levels
3) increased anticoagulant effect of warfarin
Interactions
drug interactions
General
2nd generation penicillin (penicillinase-resistant)
Properties
MISC-INFO: elimination route KIDNEY
pregnancy-category B
safety in lactation ?
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
- Deprecated Reference