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clotrimazole (Lotrimin, Mycelex, Gyne-Lotrimin, Desenex)
Oral agent: Tradename: Mycelex.
Indications:
1) oropharyngeal candidiasis
2) cutaneous fungal infection
- Tinea pedis, Tinea cruris, Tinea corporis, Tinea versicolor
- paronychia [5]
3) Candida vulvovaginosis
4) diaper rash [5]
Dosage: Lozenge 5 times/day for 14 days.
Lozenges: 10 mg.
Topical agent: Tradenames: Lotrimin, Mycelex.
1% cream/solution/lotion to area BID.
Adverse effects:
1) common (> 10%)
- abnormal liver function tests
2) less common (1-10%)
- nausea/vomiting, mild burning, irritation, stinging to skin or vaginal area
Monitor:
1) baseline liver function tests (LFTs)
2) repeat LFTs in one month
Drug interactions:
- decreases metabolism of cisapride possibly leading to prolongation of the QT interval & fatal tachyarrhythmias
Mechanism of action:
1) alteration of the cell membrane permeability via binding of phospholipids
2) fungistatic [4]
Interactions
drug interactions
General
antifungal agent
imidazole; glyoxaline; 1,3-diazole; iminazole
Properties
MISC-INFO: pregnancy-category B
safety in lactation ?
Database Correlations
PUBCHEM cid=2812
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
- Drug Information & Medication Formulary, Veterans Affairs,
Central California Health Care System, 1st ed., Ravnan et al
eds, 1998
- Prescriber's Letter 9(2):11 2002
- Deprecated Reference
Component-of
betamethasone/clotrimazole (Lotrisone)
betamethasone/clotrimazole/gentamicin
clotrimazole/gentamicin/mometasone