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clomiphene; clomiphene citrate (Clomid, Serophene)
Tradename: Clomid, Serophene. (clomiphene citrate)
Indications:
- treatment of ovulatory failure in women attempting to become pregnant
Dosage: 50 mg PO QD x 5 days (days 5-9 of menstrual cycle).
Tabs: 50 mg.
Adverse effects:
1) common (> 10%)
- hot flashes, ovarian enlargement
2) less common (1-10%)
- visual changes
- blurring, diplopia, floaters, after-images, phosphenes, photophobia
- gastrointestinal (GI)
- hepatotoxicity, distension, bloating, nausea/vomiting
- headache
- thromboembolism
- breast enlargement (males)
- abnormal menstrual flow
- depression
3) uncommon (< 1%)
- insomnia, fatigue, weight gain, reversible alopecia, increased urination
Interactions
drug adverse effects of estrogens
General
estrogen
Properties
MISC-INFO: elimination route LIVER
pregnancy-category D
X
safety in lactation ?
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998