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clobetasol propionate
see clobetasol topical
Indications:
1) short term treatment of inflammatory dermatoses
- seborrheic dermatitis, atopic dermatitis, contact dermatitis, nummular eczema [4]
2) psoriasis
3) lichen sclerosus
Dosage: (topical)
1) 0.05% cream/ointment/spray/scalp application QD/BID
2) up to 2 weeks of therapy
- 4 weeks then gradually taper over 2-3 months for lichen sclerosus
3) maximum: 50 g/week
4) avoid application of occlusive dressing to the site(s) of clobetasol administration
Solution: (0.05%) for scalp 25 & 50 mL. Cream (0.05%) 15 & 30 g.
Gel: (0.05%) (propionate): 15, 30 & 45 g.
Spray: (0.05%) (Clobex, Galderma) 2 oz
Adverse effects:
1) not common (1-10%)
- skin irritation, dryness, erythema, pruritus, papular rashes
2) uncommon (< 1%)
- acneiform eruptions, hypertrichosis, hypopigmentation, perioral dermatitis, skin maceration, skin atrophy, striae, miliaria
3) other
- suppression of hypothalamic-pituitary-adrenal axis
Mechanism of action: high-potency corticosteroid
Interactions
drug interactions
drug adverse effects (more general classes)
monitor with drug (more general classes)
General
antipruritic agent
glucocorticoid
Properties
MISC-INFO: pregnancy-category C
safety in lactation ?
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Drug Information & Medication Formulary, Veterans Affairs,
Central California Health Care System, 1st ed., Ravnan et al
eds, 1998
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
- Deprecated Reference
- http://www.galderma.com
Component-of
clobetasol/coal tar