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C-type lectin domain family 5 member A; C-type lectin superfamily member 5; myeloid DAP12-associating lectin 1; MDL-1 (CLEC5A CLECSF5 MDL1)
Function:
- may be involved in proinflammatory activation of myeloid cells via TYROBP-mediated signaling (Ca+2-dependent)
- interacts with TYROBP
Structure:
- contains 1 C-type lectin domain
Compartment:
- membrane; single-pass type 2 membrane protein (probable)
Alternative splicing: named isoforms=2
Expression:
- expressed in peripheral blood monocytes & in the monocyte/macrophage cell lines U937 & monomac6
- not expressed in cell lines of other origins
- expression is down-regulated when monocytes differentiate into dendritic cells
General
C-type (calcium dependent, carbohydrate-recognition domain) lectin superfamily or C-type lectin domain family
Properties
SIZE: entity length = 188 aa
MW = 22 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {5-27}
N-glycosylation site {N32}
cysteine residue {C71}
MODIFICATION: cysteine residue {C82}
C-type lectin {78-184}
MOTIF: cysteine residue {C82}
MODIFICATION: cysteine residue {C71}
N-glycosylation site {N93}
cysteine residue {C99}
MODIFICATION: cysteine residue {C183}
N-glycosylation site {N144}
N-glycosylation site {N151}
cysteine residue {C161}
MODIFICATION: cysteine residue {C175}
cysteine residue {C175}
MODIFICATION: cysteine residue {C161}
cysteine residue {C183}
MODIFICATION: cysteine residue {C99}
Database Correlations
OMIM 604987
UniProt Q9NY25
Pfam PF00059
Entrez Gene 23601
Kegg hsa:23601
References
- UniProt :accession Q9NY25
- Functional glycomics gateway - glycan binding; Note: MDL-1
http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Ctlect_244